Applying next-generation sequencing to detect microsatellite instability in pan-cancer patients: a retrospective study of 35,563 Chinese cases.

Microsatellite instability (MSI) serves as an important therapeutic and prognostic marker. Immunohistochemistry (IHC) and polymerase chain reaction (PCR) have long been regarded as the "gold standard" for MSI detection. In recent years, next-generation sequencing (NGS)-based methods, offering expanded target coverage of microsatellite (MS) loci and improved analytical performance, have gained widespread acceptance.

Achieving Highly Roust Polymeric Microspheres with Efficient and Full-Color Organic Afterglow for 3D Printing and Anti-Counterfeiting.

In this work, highly robust polymer-based luminescent microspheres with efficient and full-color organic afterglow are developed for the first time. N-phenylnaphthalen-1-amine, N-phenylphenanthren-9-amine, and N-phenyltriphenylen-2-amine are employed as guest luminogens and embedded into melamine-formaldehyde polymer matrices with compact and permanent three-dimensional (3D) covalent networks via host-guest doping and emulsion polymerization. The resulting polymeric microspheres, with a diameter of ≈2 µm, show blue to yellow-green organic afterglow at room temperature.

Enabling Highly Robust Full-Color Ultralong Room-Temperature Phosphorescence and Stable White Organic Afterglow from Polycyclic Aromatic Hydrocarbons.

In this work, full-color and stable white organic afterglow materials with outstanding water, organic solvents, and temperature resistances have been developed for the first time by embedding the selected polycyclic aromatic hydrocarbons into melamine-formaldehyde polymer via solution polymerization. The afterglow quantum yields and lifetimes of the resulting polymer films were up to 22.7 % and 4.

Achieving Stable and Switchable Ultralong Room-Temperature Phosphorescence from Polymer-Based Luminescent Materials with Three-Dimensional Covalent Networks for Light-Manipulated Anticounterfeiting.

Developing polymer-based organic afterglow materials with switchable ultralong organic phosphorescence (UOP) that are insensitive to moisture remains challenging. Herein, two organic luminogens, BBCC and BBCS, were synthesized by attaching 7-benzo[]carbazole (BBC) to benzophenone and diphenyl sulfone. These two emitters were employed as guest molecules and doped into epoxy polymers (EPs), which were constructed by in situ polymerization to achieve polymer materials BBCC-EP and BBCS-EP.

Polymer-Based Long-Lived Phosphorescence Materials over a Broad Temperature Based on Coumarin Derivatives as Information Anti-Counterfeiting.

The development of new polymer-based room-temperature phosphorescence materials is of great significance. By a special molecule design and a set of feasible property-enhancing strategies, coumarin derivatives (CMDs, M-M) were doped into polyvinyl alcohol (PVA), polyacrylamide (PAM), corn starch, and polyacrylonitrile (PAN) as information anti-counterfeiting. CMDs-doped PVA and CMDs-doped corn starch films showed long-lived phosphorescence emissions up to 1246 ms (M-PVA) and 697 ms (M-corn starch), reaching over 10 s afterglow under naked eye observation under ambient conditions.