Efficacy and safety of obinutuzumab in primary membranous nephropathy: a real-world retrospective study.

Objective: This study aimed to evaluate the efficacy and safety of obinutuzumab, a novel anti-CD20 monoclonal antibody, in patients with primary membranous nephropathy (pMN).

Methods: Fifty-five patients with pMN treated with obinutuzumab were respectively enrolled in this study. Clinical and immunological response, renal function and adverse events were assessed throughout the follow-up period between patients receiving obinutuzumab as initial therapy and alternative therapy.

Photocatalytic remote alkenylation of hydroxamides with enamides: synthesis of trisubstituted enamides a radical pathway.

A photocatalytic radical-mediated strategy has been developed for the 1,5-hydrogen atom transfer (1,5-HAT)/alkenylation of hydroxamides with enamides, enabling the efficient synthesis of diverse, previously unreported trisubstituted enamides in moderate to good yields under mild conditions. This -centered radical-triggered γ-C(sp)-H alkenylation reaction demonstrates broad substrate scope, excellent functional group tolerance, and remarkable regio- and stereoselectivity. The proposed mechanism involves a sequential cascade of single-electron transfer (SET), 1,5-HAT, radical addition, oxidation, and deprotonation.

[Correlation between pathological features at the positive margin and biochemical recurrence after radical prostatectomy in patients with organ-confined prostate cancer].

Objective： To investigate the correlation between pathological features at the positive margins and biochemical recurrence after radical prostatectomy for prostate cancer. Methods： From June 2014 to December 2019, a total of 200 patients with organ-confined prostate cancer who underwent radical prostatectomy were included in this study by the method of case matching (1∶1). One hundred patients with positive surgical margin and 100 with negative surgical margin were enrolled in this study.

FeO nanoparticles induce ferroptosis by binding to the N-terminus of ACSL4 and suppressing its ubiquitin-mediated degradation.

Within intracellular environments, nanoparticles (NPs) interact with numerous proteins, thereby modulating their functionality and subsequent cellular processes. Ferroptosis represents a unique form of cell death that relies on lipid peroxidation. However, the underlying mechanism by which FeO NPs induce ferroptosis remains elusive.

Serum ferritin is a superior biomarker for evaluating disease activity and kidney injury compared with C-reactive protein in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Background: Elevated C-reactive protein (CRP) is a characteristic of active anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, its relationship with organ involvement severity is ambiguous. Serum ferritin (SF) is a proinflammatory marker elevated in many autoimmune diseases, yet its role in AAV is poorly studied.

Transcriptional responses of three slc39a/zip members (zip4, zip5 and zip9) and their roles in Zn metabolism in grass carp (Ctenopharyngodon idella).

In order to explore the regulatory mechanism of zip4, zip5 and zip9 in zinc metabolism of grass carp (Ctenopharyngodon idella), the effects of zinc (Zn) on the mRNA expression of zip4, zip5 and zip9 were investigated. Compared to the control, the mRNA levels of zip4 and zip9 were significantly reduced under low and high zinc in L8824 cells; the mRNA expression level of zip5 was significantly increased under low and high zinc incubation. Then, their promoter sequences were cloned, which were 2361 bp, 2004 bp and 2186 bp sequences for zip4, zip5 and zip9 promoters, respectively.

Organoelectrocatalytic cyclopropanation of alkenyl trifluoroborates with methylene compounds.

Cyclopropanes are not only privileged motifs in many natural products, agrochemicals, and pharmaceuticals, but also highly versatile intermediates in synthetic chemistry. As such, great effort has been devoted to the cyclopropane construction. However, novel catalytic methods for cyclopropanation with two abundant substrates, mild conditions, high functional group tolerance, and broad scope are still highly desirable.

Electrochemical Ring-Opening of Cyclopropylamides with Alcohols toward the Synthesis of 1,3-Oxazines.

An electrochemical method is presented to construct 1,3-oxazines by the oxidative ring-opening of cyclopropylamides with alcohols. This method avoids the use of external oxidants and thus shows good functional group tolerance. The substrate scope covers primary, secondary, and tertiary alcohols as well as (hetero)aryl amide-substituted cyclopropanes.

Characterization and expression analysis of seven lipid metabolism-related genes in yellow catfish Pelteobagrus fulvidraco fed high fat and bile acid diet.

SREBPs, such as SREBP1 and SREBP2, were the key transcriptional factors regulating lipid metabolism. The processing of SREBPs involved many genes, such as scap, s1p, s2p, cideb. Here, we deciphered the full-length cDNA sequences of scap, srebp1, srebp2, s1p, s2p, cideb and cidec from yellow catfish Pelteobagrus fulvidraco.

Severe acute interstitial nephritis induced by valsartan: A case report.

Rationale: Angiotensin receptor blocker (ARB) can increase serum creatinine or potassium levels in patients with renal insufficiency, renal artery stenosis, heart failure or hypovolemia, but hardly cause severe kidney injury in patients without any risk factors. A case of severe acute interstitial nephritis (AIN) induced by valsartan was reported here.

Patient Concerns: A 62-year-old female with nausea for 1 month and acute deterioration of kidney function for 2 weeks was admitted.