Publications by authors named "Pascal Leprince"

While biventricular assist devices (BiVADs) remain underutilized in Western countries for biventricular heart failure (BHF), their application is expanding in China. This consensus synthesizes international guidelines, medical evidence, and Chinese clinical expertise to establish standardized protocols for BiVAD management. Key recommendations include: (1) Preoperative right heart catheterization and echocardiography for central venous pressure (CVP): pulmonary capillary wedge pressure (PCWP) ratio and pulmonary artery pulsatility index (PAPi) assessment (Class I); (2) BiVAD indication in refractory BHF or high-risk right heart failure post-left ventricular assist device (LVAD) implantation (Class IIa); (3) Right atrial implantation as the preferred surgical approach (Class IIa); (4) Warfarin-based anticoagulation (INR 2.

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Background: Cardiothoracic surgeons are essential healthcare practitioners but there are demographic challenges and training complexities. Understanding workforce trends is critical to ensure future capacity and adaptability in France.

Aims: This study assessed the current state of the cardiothoracic surgery workforce in France and projected demographic trends through 2040.

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Objective: By developing a reproducible step-by-step approach to aortic valve (AV) repair, we aim to increase the global rate of successful AV repair. Although valve-sparing root replacement is a Class I recommendation with level B evidence for root aneurysm, regardless of the degree of aortic regurgitation, its utilization remains limited. This study evaluated the feasibility, reproducibility, and effectiveness of a standardized AV repair performed by a fellow versus an expert.

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Purpose: Cardiac surgery associated acute kidney injury (CSA-AKI) is a frequent and severe complication. Goal Directed Perfusion (GDP) during cardiopulmonary bypass (CPB) has been developed to reduce post-operative complications, in particular CSA-AKI. Hence, we aimed to assess the implementation of a GDP strategy during CPB on the incidence of CSA-AKI in a large, unselected cardiac surgery population.

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Improved approaches for organ preservation have been recently applied in heart transplantation to prevent the risk of primary graft dysfunction. To review heart-graft preservation systems and to identify criteria for using innovative devices in each specific situation. A working group of the French Society of Thoracic and Cardiovascular Surgery performed a literature review focusing on organ preservation and post-transplant outcomes.

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Background: Heart transplantation is an emergency surgery requiring cardio-pulmonary bypass (CPB) and its timing is unpredictable. Patients on the transplant waiting list often have multiple reasons for being anticoagulated. Intraoperative removal of apixaban using CytoSorb seems to be an interesting solution for patients on DOACs requiring an emergency CPB intervention.

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Objectives: Practice concerning post-transplant Pneumocystis prophylaxis remains heterogeneous. SXT benefits must be balanced with frequent toxicity. We aimed to assess whether a low-dose SXT strategy might limit toxicities while maintaining an undisrupted prophylaxis compared with a standard dose in a retrospective cohort of heart transplant population.

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Objectives: This study provides a thorough analysis of cardiac surgeons' involvement in transcatheter aortic valve replacement (TAVR) activities in France, covering decision-making, procedural roles, training and outcome analysis.

Methods: A nationwide survey was sent to all cardiac surgeons and all cardiac surgery trainees in France. Subgroup analysis was performed for age, status (established versus in-training) and type of practice facility.

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Objective: The study objective was to evaluate outcomes of patients directly bridged with venoarterial extracorporeal membrane oxygenation to heart transplantation.

Methods: A single-center retrospective study was performed on 1152 adult patients undergoing isolated cardiac transplantation between January 2007 and December 2021. Among these, patients bridged with an extracorporeal membrane oxygenation to transplantation (extracorporeal membrane oxygenation group, n = 317) were compared with standard cohorts of patients (no extracorporeal membrane oxygenation group, n = 835).

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Background: Lower ministernotomy offers the advantage of providing excellent visualization of the 4 cardiac cavities, thus allowing surgical treatment of the aortic, mitral, and tricuspid valves as well as any intracavitary procedure. Information on technical issues, as well as safety and echocardiographic results of this approach, are sparse. The aim of this retrospective study was to describe outcomes of lower ministernotomy to treat valvulopathies and for other intracardiac surgical procedures.

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Purpose: Whether skin disinfection of the surgical site using chlorhexidine-alcohol is superior to povidone-iodine-alcohol in reducing reoperation and surgical site infection rates after major cardiac surgery remains unclear.

Methods: CLEAN 2 was a multicenter, open-label, randomized, two-arm, assessor-blind, superiority trial conducted in eight French hospitals. We randomly assigned adult patients undergoing major heart or aortic surgery via sternotomy, with or without saphenous vein or radial artery harvesting, to have all surgical sites disinfected with either 2% chlorhexidine-alcohol or 5% povidone-iodine-alcohol.

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Article Synopsis
  • This study examines the effectiveness of switching patients from peripheral veno-arterial ECMO (pECMO) to central ECMO (cECMO) as a treatment strategy for refractory cardiogenic shock (rCS).
  • Out of 80 patients analyzed, only 38% were successfully bridged to recovery, heart transplantation, or a ventricle assist device, while the remaining 62% died during cECMO treatment.
  • Complications were common, with high rates of renal issues and bleeding, and the study found that myocardial infarction significantly increased the risk of in-hospital mortality.
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  • Type A acute aortic dissection (TAAAD) is a serious medical emergency requiring immediate surgical intervention, and understanding treatment options is crucial for improving patient outcomes.
  • A multicenter observational registry called AoArch has been established, combining data from four cardiac surgery centers in Europe to analyze the effects of hemiarch repair (HAR) versus extended arch repair (EAR) on patient outcomes following TAAAD surgery.
  • The study will assess various factors, such as patient co-morbidities and surgical strategies, to measure both early and late adverse events, with a focus on defining mortality rates and complications related to TAAAD treatments.
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  • The study focuses on the incidence and outcomes of prosthetic valve thrombosis in patients who received peripheral veno-arterial extracorporeal membrane oxygenation (pVA-ECMO) after valve replacement surgery for postcardiotomy cardiogenic shock (PCCS).
  • It involved a retrospective analysis of 549 patients, with 152 having valve replacements, and found that 9 developed thrombosis, resulting in a 30-day thrombosis incidence of approximately 7.5%.
  • The findings suggest that using an intra-aortic balloon pump (IABP) in conjunction with pVA-ECMO significantly reduces the risk of valve thrombosis and is linked to lower hospital mortality rates.
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  • High-risk pulmonary embolism (PE) patients can experience hemodynamic instability despite treatment; VA-ECMO is explored as a life-saving intervention, but pre-treatment with systemic thrombolysis poses risks of bleeding.
  • A study covering 72 patients assessed ECMO complications and survival rates, revealing similar 90-day survival rates and bleeding incidents between those treated with systemic thrombolysis and those without.
  • Long-term quality of life for survivors was found to be acceptable, indicating that recent systemic thrombolysis shouldn't be deemed a contraindication for VA-ECMO in high-risk PE cases.
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  • Right ventricular failure (RVF) is a critical issue leading to high mortality rates shortly after heart transplantation, and the study explores how isoproterenol (Iso) can help improve heart function in these patients.
  • A retrospective study over one year evaluated the hemodynamic effects of Iso in 25 patients with early RVF, comparing no Iso treatment to low and high doses of Iso.
  • Results showed that Iso significantly increased heart rate and cardiac index, indicating improved heart function, while its effects on pulmonary pressures were minimal, highlighting its potential as a beneficial treatment for RVF post-heart transplant.
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Objectives: This study aimed to identify perioperative risk factors of acute kidney injury after heart transplantation and to evaluate 1-year clinical outcomes.

Design: A retrospective single-center cohort study.

Setting: At a university hospital.

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  • Management of dual antiplatelet therapy (DAPT) in VA-ECMO patients post-acute myocardial infarction (AMI) presents challenges, with significant occurrences of severe bleeding and coagulation issues.
  • A study analyzed 176 post-AMI patients on VA-ECMO, finding nearly 39% experienced severe bleeding and a high mortality rate of 49%.
  • Factors such as female sex, duration on ECMO, and certain biomarkers were linked to an increased risk of severe bleeding, which led to the discontinuation of antiplatelet therapy in one-third of the cases.
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  • The EFCAD registry is a study aimed at understanding how transit-time flow measurement (TTFM) impacts the outcomes of coronary artery bypass grafting (CABG) surgeries.
  • The study collected data from 1616 patients across 9 centers, analyzing factors like major adverse cardiac events and graft revisions, with significant findings linked to graft flow measurements.
  • Results indicated that inadequate flow in left anterior descending artery grafts negatively affects patient outcomes, suggesting that TTFM should be routinely employed in CABG procedures for better results.
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  • Type A acute aortic dissection (TAAAD) is a life-threatening condition that requires urgent treatment, with a current survival rate post-surgery around 20%, and high arterial lactate levels are identified as a crucial predictor of poor outcomes.
  • The study evaluated 633 patients over a 17-year period, focusing on those with complete preoperative data, revealing that early postoperative mortality was 24.5% with malperfusion significantly affecting survival rates.
  • Results showed that while there was no notable difference in mortality between conservative and extensive surgical approaches, elevated preoperative arterial lactates correlated with malperfusion and increased risk of death, warranting further investigation into its prognostic relevance.
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  • Fulminant myocarditis is a serious condition that requires accurate diagnosis, typically through a myocardial biopsy, but the procedure carries risks, and its effectiveness for treatment is unclear.
  • A study at a French ICU examined patients who were on mechanical circulatory support (MCS) and underwent biopsy, finding that while the diagnosis of definite myocarditis increased significantly after biopsy, the actual change in treatment was minimal.
  • The study concluded that the risks associated with myocardial biopsy may outweigh its benefits in these vulnerable patients, suggesting a need for more caution in deciding to perform the procedure.
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Background: Although, valve sparing is commonly performed in patients with Marfan syndrome, feasibility and results of cusp repair for aortic insufficiency have not been studied.

Aim: To report on the outcomes and durability of aortic cusp repair in valve sparing in patients with Marfan syndrome.

Methods: All consecutive adult patients with Marfan syndrome who underwent remodelling and annuloplasty with aortic valve repair for aortic insufficiency between May 2005 and December 2020 were included.

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