Determination of the Optimum Architecture of Additively Manufactured Magnetic Bioactive Glass Scaffolds for Bone Tissue Engineering and Drug-Delivery Applications.

For better bone regeneration, precise control over the architecture of the scaffolds is necessary. Because the shape of the pore may affect the bone regeneration, therefore, additive manufacturing has been used in this study to fabricate magnetic bioactive glass (MBG) scaffolds with three different architectures, namely, grid, gyroid, and Schwarz D surface with 15 × 15 × 15 mm dimensions and 70% porosity. These scaffolds have been fabricated using an in-house-developed material-extrusion-based additive manufacturing system.

Narrow spectrum nano-antibiotic for selective removal of ARB from contaminated water: New insights into stimuli response based on cellular attachment, lysis, and excretion.

Narrow spectrum nano-antibiotics are supposedly the future trouble-shooters to improve the efficacy of conventional antimicrobials for treatment of severe bacterial infections, remove contamination from water and diminish the development of antibiotic resistance. In this study, antimicrobial peptide functionalized boron-carbon-nitride nanosheets ((Ant)pep@BCN NSs) are developed that are a promising wastewater disinfector and antibiotic resistant bactericide agent. These nanosheets are developed for selective removal and effective inactivation of antibiotic resistant bacteria (ARB) from water in presence of two virulent bacteria.

Additive Manufacturing of Iron Carbide Incorporated Bioactive Glass Scaffolds for Bone Tissue Engineering and Drug Delivery Applications.

In this study, we have synthesized a bioactive glass with composition 45SiO-20NaO-23CaO-6PO-2.5BO-1ZnO-2MgO-0.5CaF (wt %).

3D-Printed Multifunctional Ag/CeO/ZnO Reinforced Hydroxyapatite-Based Scaffolds with Effective Antibacterial and Mechanical Properties.

Conventional three-dimensional (3D)-printed hydroxyapatite (HA)-based constructs have limited utility in bone tissue engineering due to their poor mechanical properties, elevated risk of microbial infection, and limited pore interconnectivity. 3D printing of complex multiple components to fabricate fully interconnected scaffolds is a challenging task; here, in this work, we have developed a procedure for fabrication of printable ink for complex systems containing multinanomaterials, i.e.

Closed-loop vasculature network design for bioprinting large, solid tissue scaffolds.

Vascularization is an indispensable requirement for fabricating large solid tissues and organs. The natural vasculature derived from medical imaging modalities for large tissues and organs are highly complex and convoluted. However, the present bioprinting capabilities limit the fabrication of such complex natural vascular networks.

Polymer-Coated and Nanofiber-Reinforced Functionally Graded Bioactive Glass Scaffolds Fabricated Using Additive Manufacturing.

In this study, carbon nanotube (CNT) reinforced functionally graded bioactive glass scaffolds have been fabricated using additive manufacturing technique. Sol-gel method was used for the synthesis of the bioactive glass. For ink preparation, Pluronic F-127 was used as an ink carrier.

Effects of Boron Oxide Concentration and Carbon Nanotubes Reinforcement on Bioactive Glass Scaffolds for Bone Tissue Engineering.

In this work, the effect of varying content of B₂O₃ with respect to SiO₂ on mechanical and bioactivity properties have been evaluated for borosilicate bioactive glasses containing SiO₂, B₂O₃, CaO and P₂O. The bioactive glasses have been synthesized using the sol-gel technique. The synthesized glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and Field Emission Scanning electron microscopy (FESEM).

Experimental and theoretical investigations of methyl orange adsorption using boron nitride nanosheets.

Fractions of dyes, that are used in large quantities for various applications, are lost during the dying process and contaminate water. In order to avoid their harmful effect on human health, boron nitride nanosheets (BNNSs) have been synthesized in this work and their adsorption behavior for the removal of anionic methyl orange (MO) dye from aqueous solution has been reported. The effect of pH, contact time, and initial dye concentration has been investigated on MO to find the optimum pH, equilibrium and adsorption capacity of the synthesized BNNSs.

Association of post-resuscitation inflammatory response with favorable neurologic outcomes in adults with in-hospital cardiac arrest.

Background: Early prediction of mortality in adults after in-hospital cardiac arrest (IHCA) remains vital to optimizing treatment strategies. Inflammatory cytokines specific to early prognostication in this population have not been well studied. We evaluated whether novel inflammatory cytokines obtained from adults with IHCA helped predict favorable neurologic outcome.

Effect of aging on heat transfer, fluid flow and drug transport in anterior human eye: A computational study.

There are a lot of geometrical and morphological changes that happen in the human eye with age. Primary open-angle glaucoma, which is caused by the increase in intraocular pressure inside the anterior chamber of the eye is also associated with the physiological aging of the eye. Therefore, it is crucial to understand the effects of aging on drug delivery in the human eye when applied topically.

Numerical modeling of therapeutic lens drug delivery in the anterior human eye for the treatment of primary open-angle glaucoma.

A numerical model of drug delivery from a therapeutic lens in the anterior portion of the human eye has been developed for a more effective treatment plan of primary open-angle glaucoma. The numerical model takes into account the drug diffusion through the therapeutic lens along with heat transfer and aqueous humor flow in different orientations of the human eye (supine (two-dimensional) as well as standing (three-dimensional)). Results illustrate that the drug diffuses through the therapeutic lens to the cornea and is convected into the anterior chamber of the eye due to the temperature gradient across the eye.

FeO-Functionalized Boron Nitride Nanosheets as Novel Adsorbents for Removal of Arsenic(III) from Contaminated Water.

We report the application of FeO-functionalized boron nitride nanosheets (BNNS-FeO nanocomposite) for the remediation of As(III) ions from contaminated water. The specific surface area of the nanocomposite has been found as 179.5 m g.

Synthesis of High Surface Area Boron Nitride Nanosheets for the Removal of Methylene Blue and Rhodamine B Dyes from Contaminated Water.

In this study, we report the synthesis and characterization of boron nitride nanosheets (BNNSs), and their application as an adsorbent to remove the cationic dyes methylene blue (MB) and rhodamine B (RhB) from contaminated water. The synthesized adsorbent was characterized by high-resolution transmission electron microscopy (HR-TEM), field emission electron microscopy (FE-SEM), X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR) and nitrogen adsorption-desorption isotherm. Detailed experiments and analysis were performed on various molar ratios of boron and nitrogen precursors (1:5 to 1:48) to achieve maximize specific surface area of BNNSs.

Magnetite-Coated Boron Nitride Nanosheets for the Removal of Arsenic(V) from Water.

It is widely known that the existence of arsenic (As) in water negatively affects humans and the environment. We report the synthesis, characterization, and application of boron nitride nanosheets (BNNSs) and FeO-functionalized BNNS (BNNS-FeO) nanocomposite for removal of As(V) ions from aqueous systems. The morphology, surface properties, and compositions of synthesized nanomaterials were examined using scanning electron microscopy, transmission electron microscopy, X-ray powder diffraction, surface area analysis, zero-point charge, and magnetic moment determination.

Comparison of transport of chemotherapeutic drugs in voxelized heterogeneous model of human brain tumor.

Systemic administration of chemotherapeutic drugs is widely used in the treatment of cancer. However, a good understanding of drug transport barriers that influence the treatment efficacy is still lacking. In this study, a voxelized numerical model based on dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) and computational fluid dynamics (CFD) is employed to study the transport and efficacy of three different chemotherapeutic drugs, namely methotrexate, doxorubicin and cisplatin in human brain tumors.

Compressive Strength Enhancement of Carbon Nanotube Reinforced 13-93B1 Bioactive Glass Scaffolds.

45S5 Bioglass® has been used quite extensively in the form of particulate as synthetic bone graft. However, 45S5 glass has certain limitations such as difficulty in sintering and slow and partial conversion to hydroxy carbonated apatite. In pursuit of overcoming these limitations, bioactive glasses (13-93B1) containing increased amount of B₂O₃ by partial replacement of SiO₂ have been prepared using sol-gel technique in this study.

Monitoring the Brain After Cardiac Arrest: a New Era.

Purpose Of Review: Of the approximately 350,000 out-of-hospital, and 750,000 after in-hospital cardiac arrest (CA) events in the US annually approximately 5-9% and 20% respectively may achieve return of spontaneous circulation (ROSC) after attempted cardiopulmonary resuscitation (CPR). Up to 2/3 of these initial survivors may go on die in the subsequent 24-72 hours after ROSC due to a combination of (1) on-going cerebral injury, (2) myocardial dysfunction and (3) massive systemic inflammatory response. In order to successfully manage patients more effectively, monitoring methods are needed to aid clinicians in the detection and quantification of intra-cardiac arrest and post-resuscitation pathophysiological cerebral injury processes in the intensive care unit.

Tuning the surface enhanced Raman scattering and catalytic activities of gold nanorods by controlled coating of platinum.

Galvanic replacement of silver (Ag) by platinum (Pt) on bi-metallic nanorods (NRs) having gold (Au) core and silver shell (Au@Ag) resulted in discontinuous coating of Pt over Au (Au@Pt-DC) NRs. However, a novel method has been developed in this work for the preparation of Au NRs having smooth and continuous coating of Pt (Au@Pt-C NRs) using galvanic replacement reaction of Au@Ag NRs in presence of sulphuric acid. Selective blocking by the bisulfate ions that are adsorbed on Pt surface, preventing Pt on Pt deposition seems to be the mechanism of formation of Au@Pt-C NRs.

Multifunctional Drug Delivery Systems Using Inorganic Nanomaterials: A Review.

Targeted drug delivery with controlled rate is vital for therapeutic purpose especially for cancer therapy. Advanced biomaterials with the aid of nanotechnology have evolved as efficient drug delivery systems (DDS), providing a multi-functional platform for simultaneous therapeutic and diagnostic (theranostic) functions. This review discusses current advances in synthesis and applications of inorganic materials such as quantum dots, carbon nanotubes and graphene oxides for drug delivery.

The feasibility of lung transplantation in HIV-seropositive patients.

Rationale: HIV seropositivity has long been considered a contraindication to lung transplantation, primarily because of the potential risks of added immunosuppression. In the past decade, however, experience with kidney and liver transplantation in the setting of HIV infection, with achievement of satisfactory outcomes, has grown considerably. This promising development has created a need to reconsider this contraindication to lung transplantation.

General anesthesia in a patient with Gilbert's syndrome.

Gilbert's syndrome, caused by relative deficiency of glucuronyl transferase is the commonest cause of congenital hyperbilirubinemia. We report anesthetic management in a case of Gilbert's syndrome for laparoscopic cholecystectomy under general anesthesia. Avoiding drugs which use this enzyme for its metabolisim or excretion, and minimizing the stress during the perioperative period allows safe conduct of anesthesia for these patients.

A case of unilateral Horner's syndrome diagnosed in retrospect following epidural analgesia during labour and caesarean section.

Horner's syndrome is a rare complication of epidural analgesia in labour. Although it is a sign of high sympathetic block, patients are usually haemodynamicaly stable. We report a case of undiagnosed Horner's syndrome complicating epidural analgesia in labour, where a standard dose of local anaesthetic was given for an emergency caesarean section without problems.

Effective size and zeta potential of nanorods by Ferguson analysis.

The effective hydrodynamic size and free mobility of particles of varying aspect ratio were evaluated by Ferguson analysis of gel electrophoresis. The ligand layer thickness was estimated from the difference between the effective size and the size of the metal core from TEM imaging. The zeta potential of the particles was calculated from the Ferguson analysis result by applying conventional electrophoresis theories for spheres and cylinders.

Carbon nanotube-based sensors.

Sensors continue to make significant impact in everyday life. There has been a strong demand for producing highly selective, sensitive, responsive, and cost effective sensors. As a result, research emphasis is on developing new sensing materials and technologies.