Leishmania donovani alters the host sphingolipid biosynthetic pathway regulatory microRNA hsa-miR-15a-5p for its survival.

Leishmania donovani is an intracellular protozoan parasite that has successfully evolved to manipulate host macrophages. The exact mechanism by which Leishmania spp evades macrophage function is not fully understood. Recently, several studies have shown that pathogens target host-microRNA to alter cellular pathways for their persistence.

Transcriptomic profiling to unravel the underlying causes of early gonadal development of hilsa (Tenualosa ilisha) in Bangladesh.

Hilsa (Tenualosa ilisha) is crucial to Bangladesh's economy and ecology, but recent trends show early maturation in small-sized hilsa, with unclear causes. This study aimed to identify differentially expressed genes (DEGs) between the ovaries of large and small hilsa using RNA-sequencing. Samples from both sizes were collected from the Meghna River in Chandpur District, and four ovary libraries were sequenced via the Illumina platform.

hsa-miR-330-5p regulates serine palmitoyltransferase long chain base subunit 1 and augments host protective immune response against Leishmania donovani infection.

Leishmaniasis, caused by the protozoan parasites of the genus Leishmania, poses a significant global health challenge, particularly in the resource-limited regions where it causes high mortality. Regardless in the progress of treatment strategies, the emergence of drug resistance and limited efficacy requires the search of novel therapy and therapeutic targets. MicroRNAs, the crucial post-transcriptional regulators of gene expression, play critical roles in host-pathogen interactions.

Seasonal dynamics and factors shaping microbiomes in freshwater finfish earthen aquaculture ponds in Bangladesh.

Background: The pondwater microbiome is believed to play a key role in fish health, including shaping mucosal surface microbiomes that help to protect against disease. How different physiochemical features relating to season, geographical locations, as well as crop species shape the pond water microbiome in the finfish aquaculture system, is not well established. Pangasius (Pangasianodon hypophthalmus) and tilapia (Oreochromis niloticus) are two of the most widely farmed fish species and disease is a major impediment to the expansion of their production.

Impact of climatic and water quality parameters on Tilapia (Oreochromis niloticus) broodfish growth: Integrating ARIMA and ARIMAX for precise modeling and forecasting.

This study aims to assess the impact of climatic factors and water quality parameters on the growth of tilapia broodfish and develop time series growth models using ARIMA and ARIMAX. Three years longitudinal data on tilapia growth, including length and weight were collected monthly from February 2021 to January 2024. Climatic data were obtained from the Bangladesh Meteorological Department, while water quality parameters in the broodfish pond were measured daily on-site.

PCR-based detection technique and gamma irradiation strategies for managing -induced brown rot of potato.

Purpose: The study focused on developing a rapid PCR-based detection method and employing gamma irradiation techniques to manage , aiming to produce brown rot-free export-quality potatoes. This initiative seeks to enhance potato exports from Bangladesh.

Materials And Methods: Samples of potato tubers and soil were collected from various commercially significant potato-growing areas, resulting in a total of 168 isolates from potato tubers and soil across 12 regions.

FDA-approved drugs as PIM-1 kinase inhibitors: A drug repurposed approach for cancer therapy.

PIM-1 kinase, a member of the Serine/Threonine kinase family, has emerged as a promising therapeutic target in various cancers due to its role in promoting tumor growth and resistance to conventional therapies. In this study, we employed a structure-based approach to screen 3800 FDA-approved drugs to discover potential inhibitors of PIM-1. After an initial selection of 50 candidates based on high docking scores, four drugs, stanozolol, alfaxalone, rifaximin, and telmisartan, were identified as strong PIM-1 binders, interacting with key residues in the ATP-binding pocket of the kinase.

Forecasting of tilapia () production in Bangladesh using ARIMA model.

Tilapia farming has expanded rapidly in Bangladesh over the years thanks to a suitable climate for aquaculture and a consistently increasing demand for the fish rich in vitamins and minerals. A clear picture regarding the future trend of tilapia production in Bangladesh is still not available, however. The purpose of this study was to estimate parameters that fit into the Autoregressive Integrated Moving Average (ARIMA) model for forecasting tilapia production in Bangladesh.

Correction: Investigating the role of prognostic mitophagy-related genes in non-small cell lung cancer pathogenesis via multiomics and network-based approach.

[This corrects the article DOI: 10.1007/s13205-024-04127-y.].

Investigating pH-induced conformational switch in PIM-1: An integrated multi spectroscopic and MD simulation study.

PIM-1 is a Ser/Thr kinase, which has been extensively studied as a potential target for cancer therapy due to its significant roles in various cancers, including prostate and breast cancers. Given its importance in cancer, researchers are investigating the structure of PIM-1 for pharmacological inhibition to discover therapeutic intervention. This study examines structural and conformational changes in PIM-1 across different pH using various spectroscopic and computational techniques.

Bacterial endophyte Pseudomonas mosselii PR5 improves growth, nutrient accumulation, and yield of rice (Oryza sativa L.) through various application methods.

Background: Pseudomonas spp. have drawn considerable attention due to their rhizospheric abundance and exceptional plant growth-promoting attributes. However, more research is needed on the optimal application methods of Pseudomonas mosselii for rice growth, nutrient accumulation, and yield improvement.

Exploring sustainable livelihood options for COVID-impacted rural communities in Bangladesh.

The COVID pandemic paralyzed all economy-generating sectors of Bangladesh, putting abrupt pressure on livelihood-making. In this study, two sequential surveys were conducted in the Mymensingh district of Bangladesh to gain a deep understanding of the impacts of COVID on job status and post-COVID job preference. The effectiveness of preferred occupations in livelihood resilience within the Sustainable Livelihood Approach (SLA) framework was also empirically analyzed and people-driven policies were recommended for sustaining livelihoods.

Impact of climatic factors on water quality parameters in tilapia broodfish ponds and predictive modeling of pond water temperature with ARIMAX.

Climate change represents a considerable threat to aquatic ecosystems, potentially affecting various water quality parameters.The study aims to assess the impacts climatic factors on the water quality parameters in tilapia broodfish pond and forecasting of water temperature in a tilapia broodfish pond using the ARIMAX model. Daily longitudinal time series data on water quality parameters were collected from the pond, while monthly climatic data were obtained from the Bangladesh Meteorological Department.

Targeting prostate cancer via therapeutic targeting of PIM-1 kinase by Naringenin and Quercetin.

PIM-1 kinase belongs to the Ser/Thr kinases family, an attractive therapeutic target for prostate cancer. Here, we screened about 100 natural substances to find potential PIM-1 inhibitors. Two natural compounds, Naringenin and Quercetin, were finally selected based on their PIM-1 inhibitory potential and binding affinities.

Multi-Tracking Sensor Architectures for Reconstructing Autonomous Vehicle Crashes: An Exploratory Study.

With the continuous development of new sensor features and tracking algorithms for object tracking, researchers have opportunities to experiment using different combinations. However, there is no standard or agreed method for selecting an appropriate architecture for autonomous vehicle (AV) crash reconstruction using multi-sensor-based sensor fusion. This study proposes a novel simulation method for tracking performance evaluation (SMTPE) to solve this problem.

A comprehensive scenario of heavy metals pollution in the rivers of Bangladesh during the last two decades.

For decades, rivers have been used for transporting pollutants loaded with heavy metals (HMs) causing severe pollution in downstream. The current study aimed to review the levels and sources of 10 HMs, viz. As, Pb, Cd, Cr, Fe, Mn, Cu, Co, Ni, and Zn in the surface water of the rivers in Bangladesh.

Corrigendum to "Forecasting of Tilapia (Oreochromis niloticus) production in Bangladesh using ARIMA model".

[This corrects the article DOI: 10.1016/j.heliyon.

Cost-effectiveness of diagnosis and treatment of early gestational diabetes mellitus: economic evaluation of the TOBOGM study, an international multicenter randomized controlled trial.

Background: A recently undertaken multicenter randomized controlled trial (RCT) " (TOBOGM: 2017-2022) found that the diagnosis and treatment of pregnant women with early gestational diabetes mellitus (GDM) improved pregnancy outcomes. Based on data from the trial, this study aimed to assess the cost-effectiveness of diagnosis and treatment of early GDM (from <20 weeks') among women with risk factors for hyperglycemia in pregnancy compared with usual care (no treatment until 24-28 weeks') from a healthcare perspective.

Methods: Participants' healthcare resource utilization data were collected from their self-reported questionnaires and hospital records, and valued using the unit costs obtained from standard Australian national sources.

Effects of Commercial Probiotics on the Growth Performance, Intestinal Microbiota and Intestinal Histomorphology of Nile Tilapia () Reared in Biofloc Technology (BFT).

Though different types of commercial probiotics are supplemented in biofloc technology (BFT), very little information is available on their effects on the farmed fish. Therefore, this study focused on evaluating the effects of three most commonly used commercial probiotics on the growth performance, intestinal histomorphology, and intestinal microbiota of Nile tilapia () reared in BFT. Tilapia fry, with an average weight of 3.

Utilization of factory tea () wastes in eco-friendly dyeing of jute packaging fabrics.

Eco-friendly dyeing of jute packaging fabrics was evaluated using aqueous extraction of factory tea ( wastes. Jute and factory tea wastes are available in Bangladesh and jute bags are used for packaging of various exportable agricultural commodities. The extract of factory tea waste (FTW) is dark coffee colored and it was characterized by attenuated total reflection-fourier transform infrared (ATR-FTIR) and microbial analysis.

In Vitro and In Vivo Anti-Inflammatory Activity of a Combination of Extracts from Cinnamomum zeylanicum, Alpinia galanga, and Withania somnifera used in Unani Medicine.

Objectives: Continuous and excessive secretion of pro-inflammatory and anti-inflammatory chemicals and cytokines may further deteriorate inflammation. Anti-inflammatory drugs play an imperative role in inhibiting the evolution of inflammatory diseases. As per the Unani doctrine, a holistic treatment approach is used to treat illnesses.

Uncovering the role of aquaporin and chromobox family members as potential biomarkers in head and neck squamous cell carcinoma via integrative multiomics and in silico approach.

Head and neck squamous cell carcinoma (HNSC) is a diverse group of tumors arising from oral cavity, oropharynx, larynx, and hypopharynx squamous epithelium, posing significant morbidity. Aquaporins (AQPs) are membrane proteins forming water channels, some associated with carcinomas. Chromobox (CBX) family is known to modulate physiological and oncological processes.