In Vitro Detection of Acaricide Resistance in Hyalomma Species Ticks with Emphasis on Farm Management Practices Associated with Acaricide Resistance in Abu Dhabi, United Arab Emirates.

Acaricide usage has led to the growing problem of resistance in ticks. A heavy tick burden and the presence of ticks on animals throughout the year, despite the monthly application of acaricides, in farms in the United Arab Emirates formed the motivation for this study. The objectives of this research were as follows: (a) to assess the acaricide resistance status of the most prevalent tick spp.

Bioprotective potential of biosynthesized copper oxide nanoparticles and copper phosphite against Alternaria-solani-induced leaf spot in pepper plants.

Alternaria solani leaf spot disease (ASLS) poses a serious threat to global crop production, including peppers, resulting in notable economic losses. Bio-nanotechnology offers promising solutions for combating plant pathogens by promoting plant defenses and inhibiting pathogen growth. This study explores the effectiveness of copper oxide nanoparticles (CNPs) and copper phosphite (MAXIFOS CU®) in controlling A.

Long-term survival of and in C3H/HeJ mice and their effect on Lyme arthritis and babesiosis manifestations.

is increasingly co-transmitted with Lyme disease-causing by ticks in the endemic regions of the United States. Infection in mice by this parasite mirrors human babesiosis, such as anemia, splenomegaly, alterations in splenic leukocyte balance, and diminished humoral immunity associated with enhanced Lyme disease manifestations at the acute phase. To evaluate the long-term survival of and in mice and their effects on pathogenesis, we conducted a 16-week infection experiment in C3H/HeJ mice.

Scaffold-hopping strategy for pyrazolo[3,4-d]pyrimidines: In vitro and in silico studies of dual c-Met/STAT3 inhibition for enhanced antitumor activity.

Twenty new pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized based on scaffold hopping and linker optimizations. The pyrazolo[3,4-d]pyrimidines were assessed for their in vitro antitumor activity against a panel of NCI cancer cell lines. Compound 22b displayed the highest mean GI% of 61.

Green biosynthesis of bimetallic silver titanium dioxide nanoparticles using Pluchea indica with their anticancer, antimicrobial, and antioxidant activities.

Natural plant extracts provide a cost-effective and eco-friendly option for the synthesis of bimetallic nanoparticles, as opposed to traditional chemical or physical methods. This research involved the bio-fabrication of silver-titanium dioxide bimetallic nanoparticles (Ag-TiO BNPs) utilizing the leaf extract of Pluchea indica. The Ag-TiO BNPs underwent characterization through UV-vis spectroscopy, FTIR, TEM, XRD, and DLS techniques.

Assessing Vascular Biomarkers and Their Association with Hypertension in Paediatric Chronic Kidney Disease.

Objectives: This study aimed to examine the correlation between children with chronic kidney disease (CKD) and endothelial dysfunction biomarkers, including asymmetric dimethylarginine (ADMA), angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A), as well as blood pressure and cardiovascular risk.

Methods: This case-control study included children who were divided into 2 groups: children with CKD at different stages and healthy controls. The study was performed from November 2021 to October 2022 at El-Minia University hospitals and the general outpatient paediatric clinic at Minia University, Minya, Egypt.

Phytochemical profiling and evaluation of antioxidant, anticancer, antimicrobial and antibiofilm activities of endophytic fungi isolated from Lavandula stricta.

The emergence of multidrug-resistant pathogens underscores the urgent need for novel antimicrobial agents. In this study, ten endophytic fungal isolates (Ls1-Ls10) were isolated for the first time from Lavandula stricta and evaluated for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella oxytoca, and Candida albicans. The most potent fungal isolate Ls1 was identified as Sarocladium kiliense using morphological and molecular techniques.

Temporal Dynamic Interplay of Mouse Proteome during Protozoan Infection Alone or with Coinfection.

Apicomplexan protozoan parasite () and spirochete are tick-transmitted pathogens that cause babesiosis and Lyme disease and increasingly cause coinfections. More pronounced Lyme arthritis occurs during the acute phase of coinfection compared to alone. In susceptible C3H mice, parasitemia was quantified by microscopic examination of blood smears while live imaging of bioluminescent N40 strain-infected mice allowed monitoring of disseminated infection.

Histomorphological and Molecular Features of Colonic Large-Cell Neuroendocrine Carcinoma in a Patient With Familial Adenomatous Polyposis: A Case Report and Review of Literature.

Colorectal large-cell neuroendocrine carcinoma, a rare and aggressive type of cancer, accounts for <0.6% of all colorectal cancers. Neuroendocrine carcinomas are associated with hereditary conditions such as Lynch syndrome; however, their co-occurrence with familial adenomatous polyposis (FAP) is poorly documented.

Assessment and quantification of ipsilateral and contralateral ankle joint alignment changes after unilateral total knee arthroplasty for knee osteoarthritis with varus deformity: a retrospective cohort study.

Purpose: The study's primary objective was to assess and quantify the ipsilateral (side A) and contralateral (side B) ankle joint line orientation (AJLO) changes after unilateral total knee arthroplasty (TKA) for primary knee osteoarthritis (OA) with varus deformity. The secondary objectives were to detect if there was a correlation between the knee deformity correction and AJLO changes and if the knee and ankle clinical outcomes on the TKA side correlate with joint alignment changes.

Methods: This retrospective cohort study included 70 patients with a mean age of 61.

Automation of flow cytometry data analysis with elastic image registration.

Cell populations in flow cytometry are typically identified via visual manual gating, a time-consuming and error-prone approach to select subpopulations based on expression of cellular markers. Batch processing can be used to automate the analysis of bimodally distributed data but underperforms with highly-variable or continuously-expressed markers. We developed a visual pattern recognition automated gating tool, BD ElastiGate Software (hereafter ElastiGate), to recapitulate the visual process of manual gating by automatically adjusting gates to capture local variability.

Efficacy and safety of transjugular intrahepatic portosystemic shunt versus endoscopic variceal ligation for variceal rebleeding: a systematic review and meta-analysis.

Background: Variceal bleeding is a significant cause of morbidity and mortality among patients with cirrhosis. While both transjugular intrahepatic portosystemic shunt (TIPS) and endoscopic variceal ligation (EVL) are utilized for variceal rebleeding prevention, their comparative efficacy and safety remain debated.

Methods: A systematic review and meta-analysis were conducted to compare TIPS with EVL for variceal rebleeding prevention.

Multiple Introductions of the Asian Longhorned Tick () to the United States Revealed Using Mitogenomics.

The Asian longhorned tick (ALT), , is a three-host hard tick native to East Asia. Its opportunistic feeding habits make it an acute agricultural and medical threat, capable of spreading various zoonotic pathogens. An affinity for livestock and companion animals has allowed parthenogenetic populations of ALT to travel to and establish in overseas locations including the United States.

Genome of the invasive North American Haemaphysalis longicornis tick as a template for bovine anti-tick vaccine discovery.

Background: The ixodid tick Haemaphysalis longicornis Neumann, commonly referred to as the Asian longhorned tick, has expanded its range outside of East Asia into countries such as Australia, New Zealand, and the United States. Since the first U.S.

Neuroprotective efficacy of berberine and caffeine against rotenone-induced neuroinflammatory and oxidative disturbances associated with Parkinson's disease via inhibiting α-synuclein aggregation and boosting dopamine release.

Parkinson's disease (PD) is characterized by motor impairment, glial-mediated inflammation, redox imbalance, and α-synuclein (α-syn) aggregation. Conventional therapies relieve early PD symptoms, but they do not repair dopaminergic neurons. Berberine (BBR) and caffeine (CAF), both natural alkaloids, exhibited neuroprotective effects in many neurodegenerative disorders.

Dual Application of Methotrexate Improves Functional and Anatomical Outcomes in Diabetic Tractional Retinal Detachment.

Background And Objective: This study evaluated the use of a dual-delivery methotrexate (MTX) strategy for diabetic tractional retinal detachment (TRD). Diabetic retinopathy (DR) is a leading cause of blindness. Inflammation plays a key role in TRD, and MTX has anti-inflammatory properties.

Immediate weight-bearing after tibial plateau fractures internal fixation results in better clinical outcomes with similar radiological outcomes: a randomized clinical trial.

Purpose: To investigate the effects of adding immediate weight-bearing to tolerance into a post-operative rehabilitation program for surgically treated Tibial Plateau (TP) fractures on clinical and radiological outcomes.

Methods: A randomized control trial. 106 Patients were recruited following open reduction internal fixation (ORIF) TP fracture, with 54 patients meeting the criteria for inclusion.

UHPC Viability for Nuclear Storage Facilities: Synthesis and Critical Review of Durability, Thermal, and Nuclear Properties for Informed Mix Modifications.

Spent nuclear fuel (SNF) from the United States' nuclear power plants has been placed in dry cask storage systems since the 1980s. Due to the lack of a clear path for permanent geological repository for SNF, consolidated and long-term storage solutions that use durable concrete and avoid current aging and licensing challenges are becoming indispensable. Ultra-high-performance concrete (UHPC) is a rapidly growing advanced concrete solution with superior mechanical and durability properties that can help realize future resilient nuclear storage facilities.

The ultrastructural changes in the adult rat ovary after administration of copper oxide nanoparticles and the possible ameliorative influence of selenium.

There is an important concern about the potential health and environmental risks that may develop due to exposure to copper oxide nanoparticles (CuO-NPs). Selenium is an essential trace element. It supports the expression of a variety of selenoproteins.

Optimizing solar performance of CFTSe-based solar cells using MoSe as an innovative buffer layers.

In this study, we explore the photovoltaic performance of an innovative high efficiency heterostructure utilizing the quaternary semiconductor CuFeSnSe (CFTSe). This material features a kesterite symmetrical structure and is distinguished by its non-toxic nature and abundant presence in the earth's crust. Utilizing the SCAPS simulator, we explore various electrical specifications such as short circuit current (J), open circuit voltage (V), the fill factor (FF), and power conversion efficiency (PCE) were explored at a large range of thicknesses, and the acceptor carrier concentration doping (N).

Impact of sleep deprivation on stress levels and cognitive performance in young and middle-aged adults at a Medical University in Ajman, UAE.

Background: Inadequate sleep is a widespread public health concern, impacting physical and mental health, as well as cognitive well-being. This study explores the link between sleep quality, the inflammatory marker interleukin-6 (IL-6), and cognitive function in two age groups (18-25 years and 35 years and above) at Gulf Medical University.

Materials And Methods: Sleep quality was assessed using the Pittsburgh questionnaire, and salivary IL-6 levels were measured.

The pharmacists' interventions after a Drug and Therapeutics Committee (DTC) establishment during the COVID-19 pandemic.

Introduction: Healthcare systems in developing countries faced significant challenges during COVID-19, grappling with limited resources and staffing shortages. Assessment of the impact of pharmaceutical care expertise, particularly in critical care units during the pandemics, in developing countries remains poorly explored. The principal aim of our study was to assess the impact of the Drug and Therapeutics Committee (DTC), comprising clinical pharmacists, on the incidence, types, and severity of medication errors and associated costs in using COVID-19 medications, especially antibiotics.