Combating Lead/HFD Neurotoxicity in Rats: The Synergistic Effect of 10-Hydroxydecanoic Acid and Zinc Oxide Nanoparticles.

Exposure to heavy metals and unbalanced diets poses significant global health concerns. This study investigated the neurotoxic effect of chronic lead acetate and high-fat diet (Pb/HFD) co-exposure in rats and the neuroprotective potential of 10-hydroxydecanoic acid (HDA) and zinc oxide nanoparticles (ZnO-NPs). Rats were allocated into naive, HDA, ZnO-NPs, MIX (HDA/ZnO-NPs), Pb/HFD, Pb/HFD + HDA, Pb/HFD + ZnO-NPs, and Pb/HFD + MIX, with 10 rats per group.

Protective effects of commercial artichoke (Cynara scolymus L.) leaf powder against aflatoxin B1-induced reproductive toxicity in male rats.

Aflatoxin B (AFB) is an unavoidable environmental pollutant frequently found in feed and foodstuffs and is considered the most toxic of all aflatoxins, known to impair testicular function. This study investigated the potential protective effect of artichoke leaves powder (ArLP) against the reproductive toxicity induced by AFB in male rats. In a 42-day experiment, rats received either sterile water, 4% DMSO, ArLP (100 mg/kg/body weight), AFB (72 µg/kg/body weight), or a combination of ArLP and AFB via oral gavage.

Effect of rosuvastatin and vitamin K on vascular calcification in a rat model of adenine induced chronic kidney disease.

Vascular calcification (VC) is prevalent in patients with chronic kidney disease and raises the risk of cardiovascular death. The study aimed to evaluate the protective effects of rosuvastatin and/or vitamin K on VC in a rat model of adenine-induced CKD and to explore the potential underlying mechanisms. Forty Wistar albino rats were divided equally into five groups: rats of group I (control group) received drug vehicle, rats of group ΙΙ received an adenine containing diet, rats of group IIİ received an adenine-containing diet + oral rosuvastatin (5 mg/kg/day), rats of group ΙV received an adenine-containing diet + oral vitamin K (40 mg/kg/day) and rats of group V received adenine containing diet and combined treatment of rousvastatin and vitamin K.

Metabolomic and chemometric profiling of crimson grapes during drying and its impact on antidiabetic activity.

The present study investigates the metabolic profile and antidiabetic potential of Crimson Seedless grapes during the drying process using UPLC-QTOF-MS/MS and multivariate statistical analyses. A total of 50 metabolites were tentatively identified, including phenolic acids, flavonoids, stilbenes, anthocyanins, and lipids. Fresh grapes contain higher levels of glycosylated anthocyanins and stilbenes, while raisins exhibit an increased concentration of fatty acids and phosphatidylcholines.

Production and characterization of anti-bacterial metabolite(s) from Egyptian archaeological sites.

Antimicrobial agents produced by Xenorhabdus spp. may hold the answer to novel antimicrobial agents. Antibacterial activity of some bacterial strains isolated from different Egyptian archaeological sites was evaluated.

Network pharmacology and UPLC/MS/MS metabolic profiling unveil the anti-inflammatory potential of Trifolium alexandrinum.

Trifolium alexandrinum, commonly known as berseem clover, has long been used in traditional medicine for its diverse therapeutic properties. In this study, we explore the anti-inflammatory potential of T. alexandrinum through an integrated approach combining network pharmacology and LC-MS/MS metabolic profiling.

Synthesis and characterization of thymol-derived phenoxy acetamide derivatives using DFT, molecular docking, and parasitological investigations.

Novel phenoxy acetamide derivatives based on a thymol moiety were synthesized for target parasitological investigation. The newly synthesized compounds, , , , , and , were synthesized as phenoxy acetamide derivatives containing a phthalimide or naphthalimide ring through a condensation reaction with various acid anhydrides. Their structures were confirmed based on spectral data derived through Fourier-transform infrared, proton and carbon-13 nuclear magnetic resonance, and elemental analyses.

Multi-omics for unveiling potential antidiabetic markers from red, green and black mung beans using NIR-UPLC-MS/MS multiplex approach.

Inspired by the nutritional and biological attributes of mung beans, the current work aims to monitor metabolome patterns of different mung species and their entanglements on antidiabetic potential using NIR-UPLC-MS/MS multiplex approach combined with chemometrics. In this regard, a total of 71 chromatographic peaks spanning sugars, amino acids, flavonoids, fatty acids and their lipid derivatives, and phytosterols were chemically profiled. Coincidently, OPLS-DA underscored an obvious discrimination among the green, red and black mung species suggesting their chemical discrepancies where eriodictyol-O-glucoside, caffeic acid, formononetin-O-glucoside, viniferal and genistin serve as focal discriminators of green mung beans while lysoPC 18:2, lanosterol, gallocatechin, tyramine, petunidin 3-O-glucoside, biochanin A, vigvexin A, vignatic acid B, lysoPC 16:0 and phaseollin were the determining metabolites of red ones.

Combating oxi-inflamm-aging: Passerini adducts tethered with 1,2,3-triazoles for enhanced antioxidant defense and 5-LOX inhibition.

Oxi-inflamm-aging, a term describing the interplay between chronic oxidative stress and inflammation, is a key contributor to cellular deterioration and age-related diseases (ARDs). To target these interconnected mechanisms, we designed and synthesized novel hybrids of Passerini adducts tethered with 1,2,3-triazoles, inspired by the naturally isolated dipeptide aurantiamide acetate known for its dual anti-inflammatory and antioxidant properties. The adducts were synthesized an optimized one-pot reaction of 4-nitrophenylisonitrile, cyclohexanone, and appropriate carboxylic acids under Passerini three-component reaction (Passerini-3CR) conditions, followed by the installation of structurally diverse 1,2,3-triazoles onto the α-acyloxy carboxamides through click chemistry.

Combination of 10-hydroxy-decanoic acid and ZnO nanoparticles abrogates lead acetate-induced nephrotoxicity in rats: targeting oxidative stress and inflammatory signalling.

Lead is a heavy metal contaminant that can cause significant alterations in renal structure and function, resulting in nephrotoxicity. The fatty acids of royal jelly exhibit immunoregulatory, anticancer, anti-inflammatory, and antioxidant properties, which have garnered significant interest. The most prevalent among them is 10-hydroxydecanoic acid (10-HDA).

Neuroprotective efficacy of berberine and caffeine against rotenone-induced neuroinflammatory and oxidative disturbances associated with Parkinson's disease via inhibiting α-synuclein aggregation and boosting dopamine release.

Parkinson's disease (PD) is characterized by motor impairment, glial-mediated inflammation, redox imbalance, and α-synuclein (α-syn) aggregation. Conventional therapies relieve early PD symptoms, but they do not repair dopaminergic neurons. Berberine (BBR) and caffeine (CAF), both natural alkaloids, exhibited neuroprotective effects in many neurodegenerative disorders.

Berberine-loaded albumin nanoparticles alleviate liver damage in rats by modulating mitochondrial biogenesis and mitochondria-endoplasmic reticulum interactions.

The liver performs essential functions critical to overall health. This study evaluated the efficacy of berberine-loaded albumin nanoparticles (BRB-BSA NPs) and cisplatin in mitigating hepatic damage caused by diethylnitrosamine (DEN) and carbon tetrachloride (CCl) in male albino rats. Molecular modeling was conducted to explore BRB interactions with Sirt1, a NAD-dependent protein deacetylase involved in key cellular pathways.

A comprehensive metabolomic study of three Egyptian Salsola species revealed their potential anti-inflammatory activity.

Salsola plants are halophytic crops that are distributed worldwide, with more than 100 species figured out in Asia, the Mediterranean region and North Africa. Different Salsola species were reported to exert marked anti-inflammatory activities, whereas the potential anti-inflammatory activities of the three species, S. tetrandra, S.

In vitro and in vivo studies of selenium nanoparticles coated bacterial polysaccharide as anti-lung cancer agents.

Microbial exopolysaccharides (EPSs) possess valuable biological functions and fascinating physicochemical properties. On the other hand, lung cancer is the primary contributor to global cancer-related deaths. However, health and safety concerns have prevented the identification and approval of any medications, including chemotherapeutic agents, for lung cancer treatment to date.

Rosuvastatin/calcium carbonate co-precipitated nanoparticles: A novel synergistic approach enhancing local bone regeneration in osteoporotic rat model.

This study aimed at preparing sustained release rosuvastatin (Ru) calcium carbonate (CC) co-precipitate nano-formulation for local intra-osseous application in osteoporotic rats. Nano-formulations were prepared by the co-precipitation method using different concentrations of polyvinyl alcohol (PVA) (0.2, 0.

Nanostructured biloalbuminosomes loaded with berberine and berberrubine for Alleviating heavy Metal-Induced male infertility in rats.

Despite the remarkable biological effects of berberine (BBR), particularly on fertility, its bioavailability is low. This study aims to test the effectiveness of novel nanostructured biloalbuminosomes (BILS) of BBR and its metabolite berberrubine (M1) in treatment of testicular and prostatic lesions. M1 was semi-synthesized from BBR using microwave-assisted reaction.

10-Hydroxy Decanoic Acid and Zinc Oxide Nanoparticles Retrieve Nrf2/HO-1 and Caspase-3/Bax/Bcl-2 Signaling in Lead-Induced Testicular Toxicity.

There has been a significant increase in human exposure to heavy metals (HMs) over the course of the previous century, primarily due to the extensive industrial processes. Male infertility is a prominent complication associated with lead exposure, wherein lead has the potential to accumulate within the testes, resulting in oxidative stress and inflammation. In addition, 10-hydroxydecanoic acid (10-HDA) is a component found in the secretions of worker bees and possesses the capacity to mitigate oxidative stress and prevent inflammation.

UPLC-MS/MS and chemometrics analyses reveal chemical profile and anti-inflammatory activity of Bienertia cycloptera Bunge fractions.

Introduction: Bienertia cycloptera is a species belonging to the Chenopodiaceae family. According to earlier reports, a unique research study on the phytochemistry and biological analysis of that species was conducted.

Objective: This study presents an integrated metabolomics investigation combined with multivariate analysis of various extractive fractions of B.

The assessment of pharmacokinetics and neuroprotective effect of berberine hydrochloride-embedded albumin nanoparticles via various administration routes: comparative studies in rats.

The current study aimed to evaluate the pharmacokinetics and neuroprotective effect of well-characterised berberine-bovine serum albumin (BBR-BSA) nanoparticles. BBR-BSA nanoparticles were generated by desolvation method. Entrapment efficiency, loading capacity, particle size, polydispersity index, surface morphology, thermal stability, and release were estimated.

Aerobic phenol degradation using native bacterial consortium via ortho-and meta-cleavage pathways.

Effective bioremediation of a phenol-polluted environment harnesses microorganisms' ability to utilize hazardous compounds as beneficial degraders. In the present study, a consortium consisting of 15 bacterial strains was utilized. The current study aims to monitor the phenol biodegradation pathway.

Integrative metabolomics and chemometrics depict the metabolic alterations of differently processed red kidney beans (Phaseolus vulgaris L.) and in relation to in-vitro anti-diabetic efficacy.

Red kidney beans (RKB) serve as a powerhouse packed with a plethora of largely unexplored extraordinary chemical entities with potential significance. However, their nutraceutical applications as a functional hypoglycemic food still lag behind and warrant further investigation. With a scope to optimize chemical and biological traits of RKB, green modification approaches (processing methods) seem inevitable.