Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.

Preeclampsia is a multi-system disease that is unique to human pregnancy. Impaired extravillous trophoblast migration and invasion accompanied by poor spiral vascular remodeling is thought to be the initial reason. This study investigated cAMP-dependent protein kinase inhibitor-b(PKIB) expression in placentas and its involvement in the pathogenesis of PE.

Differential patterns of interhemispheric functional connectivity between AQP4-optic neuritis and MOG-optic neuritis: a resting-state functional MRI study.

Background: Several neuroimaging studies demonstrated that optic neuritis (ON) leads to functional and anatomical architecture changes in the brain. The alterations of interhemispheric functional connectivity (IFC) in patients with AQP4-ON and myelin oligodendrocyte glycoprotein (MOG)-ON are not well understood.

Purpose: To investigate the differential patterns of VMHC in patients with AQP4-ON and MOG-ON.

Different alteration patterns of sub-macular choroidal thicknesses in aquaporin-4 immunoglobulin G antibodies sero-positive neuromyelitis optica spectrum diseases and isolated optic neuritis.

Purpose: The ocular choroid is a sensitive biomarker of vascular perfusion in optic neuritis (ON) patients due to its vascular structures. The purpose of this study was to evaluate alterations in sub-macular choroidal thicknesses (sub-MCT) in aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) sero-positive neuromyelitis optica spectrum disease (AQP4-IgG+/NMOSD) and isolated ON (ION) patients using optical coherence tomography (OCT).

Methods: A total of 208 ON patients (275 eyes) and healthy controls (HCs) who underwent sub-MCT and retinal microstructure detection with OCT were enrolled in this study.

Melatonin protects against apoptosis of megakaryocytic cells via its receptors and the AKT/mitochondrial/caspase pathway.

Clinical studies have shown that melatonin lowers the frequency of thrombocytopenia in patients with cancer undergoing radiotherapy or chemotherapy. Here, we investigated the mechanisms by which melatonin promotes platelet formation and survival. Our results show that melatonin exerted protective effects on serum-free induced apoptosis of CHRF megakaryocytes (MKs).

Evaluation of the mechanism of Danggui-Shaoyao-San in regulating the metabolome of nephrotic syndrome based on urinary metabonomics and bioinformatics approaches.

Ethnopharmacological Relevance: Danggui-Shaoyao-San (DSS), a well-known classic Traditional Chinese medicine (TCM) formula for enhancing Qi (vital energy and spirit), invigorating blood circulation and promoting diuresis, has been widely used in the treatment of nephrotic syndrome (NS). Previously, we have reported some protective effects of DSS against NS, but the in-depth mechanisms remain unclear.

Aim Of The Study: In this study, an ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q/TOF-MS)-based urinary metabonomics coupled with bioinformatics method was employed to evaluate the mechanisms of DSS in treating NS from the perspective of metabolism.

Correction to: The old CEACAMs find their new role in tumor immunotherapy.

Correction is needed to the original version of this article.

The potential risks of paclobutrazol residue on yogurt fermentation from the level of chiral enantiomers.

In recent years, pesticide residues in food have increasingly become the focus of public attention. However, the standard system of pesticide maximum residue limits in fermented food is imperfect, which can lead to potential safety risks to consumers. In this context, the aim of the study was to assess the potential effects of paclobutrazol residue on the yogurt fermentation process.

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19.

Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. Hematological changes such as lymphopenia and thrombocytopenia are not rare in COVID-19 patients, and a smaller population of these patients had leukopenia.

The old CEACAMs find their new role in tumor immunotherapy.

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) contain 12 family members(CEACAM1、CEACAM3、CEACAM4、CEACAM5、CEACAM6、CEACAM7、CEACAM8、CEACAM16、CEACAM18、CEACAM19、CEACAM20 and CEACAM21)and are expressed diversely in different normal and tumor tissues. CEA (CEACAM5) has been used as a tumor biomarker since 1965. Here we review the latest research and development of the structures, expression, and function of CEACAMs in normal and tumor tissues, and their application in the tumor diagnosis, prognosis, and treatment.

Does influent C/N ratio affect pollutant removal and greenhouse gas emission in wastewater ecological soil infiltration systems with/without intermittent aeration?

Wastewater ecological soil infiltration system (WESIS) is a land treatment technology for decentralized wastewater treatment that has been applied all over the world. In this study, the pollutant removal, emission of greenhouse gases (GHGs) and functional gene abundances with different influent C/N ratios were evaluated in WESISs with/without intermittent aeration. Intermittent aeration and influent C/N ratio affect pollutant removal and GHG emission.

Orbital Magnetic Resonance Imaging May Contribute to the Diagnosis of Optic Nerve Lymphoma.

Optic nerve lymphoma can present a diagnostic challenge because of its confusing clinical features and the difficulty of obtaining lesion tissue for biopsy. The objective of this study was to find some flags of lymphomatous infiltration of optic nerves. We report two cases of optic nerve lymphoma and conduct a literature review to determine whether a common diagnostic characteristic can be identified.

Porphyrinic Metal-Organic Framework Nanorod-Based Dual-Modal Nanoprobe for Sensing and Bioimaging of Phosphate.

Herein, a dual-modal fluorescent/colorimetric "Signal-On" nanoprobe based on PCN-222 nanorods (NRs) toward phosphate was proposed for the first time. Due to the high affinity of the zirconium node in PCN-222 NRs for phosphate, the structure collapse of PCN-222 NRs was triggered by phosphate, resulting in the release of the tetrakis(4-carboxyphenyl)porphyrin (TCPP) ligand from PCN-222 NRs as well as the enhancement of fluorescence and absorbance signals. The PCN-222 NR-based nanoprobe could be employed for phosphate detection over a wide concentration range with a detection limit down to 23 nM.

c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis.

Thrombopoietin (TPO) is a growth factor for the megakaryocytic/platelet lineage. In this study, we investigated the expression of TPO and its receptor, c-Mpl, in the human central nervous system (CNS) and their roles after a neural insult. Our results demonstrate that both TPO and c-Mpl are expressed in the neurons of the human CNS.

Multi-modal interactive fusion method for detecting teenagers' psychological stress.

Psychological stress turns out to be increasingly severe among teenagers and has imposed numerous physical and mental issues on them. The earlier the stress is detected, the better it can be effectively managed and alleviated. Smart phones, having taken up an integral part of our daily lives, can act as a way to monitor and collect people's daily behaviors and help people manage stress.

Down-regulation of endothelial protein C receptor promotes preeclampsia by affecting actin polymerization.

Preeclampsia is a severe pregnancy-related disease that is found in 3%-5% of pregnancies worldwide and is primarily related to the decreased proliferation and invasion of trophoblast cells and abnormal uterine spiral artery remodelling. However, studies on the pathogenesis of placental trophoblasts are insufficient, and the aetiology of PE remains unclear. Here, we report that endothelial protein C receptor (EPCR), a transmembrane glycoprotein, was down-regulated in placentas from preeclamptic patients.

Tropical Cyclone Track Forecasting Using Fused Deep Learning From Aligned Reanalysis Data.

The forecast of tropical cyclone trajectories is crucial for the protection of people and property. Although forecast dynamical models can provide high-precision short-term forecasts, they are computationally demanding, and current statistical forecasting models have much room for improvement given that the database of past hurricanes is constantly growing. Machine learning methods, that can capture non-linearities and complex relations, have only been scarcely tested for this application.

An ultrasensitive and selective fluorescent nanosensor based on porphyrinic metal-organic framework nanoparticles for Cu detection.

Detecting trace amounts of copper ions (Cu2+) is of high importance since copper is an essential element in the environment and the human body. Despite the recent advances in Cu2+ detection, the current approaches still suffer from insensitivity and lack of in situ detection in living cells. In the present work, a fluorescent nanosensor based on porphyrinic metal-organic framework nanoparticles (MOF-525 NPs) is proposed for sensitive and selective monitoring of Cu2+ in aqueous solution and living cells.

Oxidative stress induced by ultrafine carbon black particles can elicit apoptosis in vivo and vitro.

Although carbon black (CB) particles have potential hazards to human health, the toxicological studies on CB are still limited. The purpose of this study was to investigate the effect of oxidative stress induced by ultrafine CB particles on apoptosis in vivo and vitro. Male C57BL/6 mice were inhalation exposed to CB for 28 days, and 16HBE cells were treated by CB particles and also added antioxidant (NAC).

The enantioselective effects and potential risks of paclobutrazol residue during cucumber pickling process.

For decades, pesticides have been widely used for controlling pests and protecting crops around the world, and the food safety issues caused by these compounds have raised widespread concern. However, the different enantioselective behaviors and biological activities of chiral pesticide enantiomers are often ignored. In this work, a novel method was put forward to investigate the enantioselective effects and potential risks of two paclobutrazol enantiomers during cucumber pickling process.

Synergistic oxidation - filtration process analysis of catalytic CuFeO - Tailored ceramic membrane filtration via peroxymonosulfate activation for humic acid treatment.

This work synthesized catalytic CuFeO tailored ceramic membrane (CuFeCM), and systematically investigated the intercorrelated oxidation - filtration mechanism of peroxymonosulfate (PMS)/CuFeCM catalytic filtration for treating humic acid (HA). PMS/CuFeCM filtration exhibited enhanced HA removal efficiency while reduced the irreversible fouling resistance as compared with the conventional CM filtration. Results from HA characterizations showed that PMS/CuFeCM catalytic filtration oxidized HA into conjugated structures of smaller molecular weight.

Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation.

Anatomically interconnected, the ventromedial prefrontal cortex (vmPFC) and amygdala interact in emotion processing. However, no meta-analyses have focused on studies that reported concurrent vmPFC and amygdala activities. With activation likelihood estimation (ALE) we examined 100 experiments that reported concurrent vmPFC and amygdala activities, and distinguished responses to positive vs.

Application of polydopamine functionalized magnetic graphene in triazole fungicides residue analysis.

In this work, a new analytical method based on polydopamine functionalized magnetic graphene (PDA@MG) adsorbent material has been developed to determine three triazole fungicides in water samples. As previous step, a novel polydopamine functionalized PDA@MG adsorbent material has been successfully prepared, which was characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscope (TEM), and vibrating sample magnetometer (VSM). Based on this novel material, a new magnetic solid phase extraction (MSPE) method coupled with high performance liquid chromatography (HPLC) has been established for the determination of triazole fungicides in water samples.

Jointly Integrating VCF-Based Variants and OWL-Based Biomedical Ontologies in MongoDB.

The development of the next-generation sequencing (NGS) technologies has led to massive amounts of VCF (Variant Call Format) files, which have been the standard formats developed with 1000 Genomes Project. At the same time, with the widespread use of biomedical ontologies in the biomedical community, more and more applications have accepted the Web Ontology Language (OWL) as the dominant data format for the specifications of biomedical ontology descriptions, leading to the rapid growth of OWL-based biomedical ontology scale. In this paper, we seek to explore an effective method for the management of VCF-based genetic variants and OWL-based biological ontologies using the MongoDB database.

Subtype-Based Prognostic Analysis of Cell-in-Cell Structures in Early Breast Cancer.

Though current pathological methods are greatly improved, they provide rather limited functional information. Cell-in-cell structures (CICs), arising from active cell-cell interaction, are functional surrogates of complicated cell behaviors within heterogeneous cancers. In light of this, we performed the subtype-based CIC profiling in human breast cancers by the "EML" multiplex staining method, and accessed their values as prognostic factors by Cox univariate, multivariate, and nomogram analysis.