A thiocoumarin based self-reporting sulfide prodrug strategy with a favorable safety profile.

HS as the third gasotransmitter is an important endogenous bioregulator that shows various therapeutic potentials. Herein, we present a novel thiocoumarin-based self-reporting sulfide prodrug strategy that utilizes esterase-mediated hydrolysis of thionoesters to release HS and provide real-time fluorescence monitoring. Our key discovery is that thionoesters can be hydrolyzed by esterases to release HS under physiological conditions, providing ample opportunities to design prodrugs based on ester-containing molecules.

A Tetrazine Amplification System for Visual Detection of Trace Analytes via Click-Release Reactions.

Achieving visual detection of analytes at ultra-low concentrations in complex mixtures remains a persistent challenge. While sophisticated techniques offer single-molecule sensitivity, practical hurdles remain, necessitating tailored signal amplification systems for direct visual detection. In this study, we develop a strategy for the visualized detection of tetrazine through a "click-release-oxidation-cycle" (CROC) cascade amplification process.

Seismic Facies Analysis Using the Multiattribute SOM-K-Means Clustering.

An accurate seismic facies analysis (SFA) can provide insight into the subsurface sedimentary facies and has guiding significance for geological exploration. Many machine learning algorithms, including unsupervised, supervised, and deep learning algorithms, have been developed successfully for SFA over the past decades. However, SFA and facies classification are still challenging tasks due to the complex characteristics of geological and seismic data.