Modular Access to P(V)-Stereogenic Compounds via Cu-Catalyzed Desymmetrization of (Thio)Phosphonic Dichlorides.

Chiral phosphorus(V) centers-particularly those bearing fully heteroatom-substituted frameworks-are key stereochemical motifs in pharmaceuticals, nucleic acid therapeutics, and functional materials. However, their stereoselective construction remains a long-standing challenge in synthetic chemistry. Here, we report a copper-catalyzed desymmetrization strategy enabled by rationally engineered PIM ligands that affords broad and modular access to structurally diverse P(V)-stereogenic compounds.

 (Rosaceae), a new species with naturally occurring semi-double flowers from Hunan, China.

The semi-double () floral trait is highly valued in the field of horticulture, yet it remains exceptionally rare in wild plants. , a new species with naturally occurring semi-double flowers, is described and illustrated. This new species was discovered in the Nanyue Hengshan National Nature Reserve, Hunan Province, China.

Modular access to saturated bioisosteres of anilines via photoelectrochemical decarboxylative C(sp)-N coupling.

In drug development, the substitution of benzene rings in aniline-based drug candidates with saturated bridged bicyclic ring systems often enhances pharmacokinetic properties while preserving biological activity. However, current efforts predominantly focuses on bicyclo[1.1.

Ligand-Enabled Cu-Catalyzed Stereoselective Synthesis of P-Stereogenic ProTides.

Nucleoside analogues have seen significant advancements in treating viral infections and cancer through ProTide technology, leading to a series of FDA-approved drugs such as sofosbuvir, tenofovir alafenamide, and remdesivir. The stereochemical configuration at the phosphorus center of ProTides significantly influences their pharmacological properties, necessitating efficient stereoselective synthesis. Traditional methods using chiral auxiliaries or nonracemic phosphorylating agents are labor-intensive and inefficient, while recent organocatalytic approaches, despite their promise, still face limitations.

Phylogenomics and integrative taxonomy reveal two new species of (Liliaceae).

Until now the genus (Liliaceae), known as 'East Asian tulips', has contained just seven species. In this study, a phylogenomic and integrative taxonomic approach was used to reveal two new species, from Central China and from East China. resembles in possessing a densely villous-woolly bulb tunic and two opposite bracts, but differs in its leaves and anthers.

Copper mediated C(sp)-H amination and hydroxylation of phosphinamides.

Copper mediated C(sp2)-H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group. This method is distinguished by its wide substrate scope and excellent functional group tolerance, thus allowing for the rapid preparation of organophosphorus compounds in organic synthesis.

Copper-Mediated Late-Stage Functionalization of Heterocycle-Containing Molecules.

One long-standing issue in directed C-H functionalization is that either nitrogen or sulfur atoms present in heterocyclic substrates may bind preferentially to a transition-metal catalyst rather than to the desired directing group. This competitive binding has largely hindered the application of C-H functionalization in late-stage heterocycle drug discovery. Reported here is the use of an oxazoline-based directing group capable of overriding the poisoning effect of a wide range of heterocycle substrates.

Discovery of Novel Pyrazole Derivatives as Potent Neuraminidase Inhibitors against Influenza H1N1 Virus.

Ten pyrazole derivatives were synthesized and evaluated for their ability to inhibit the replication of influenza virions. All the compounds were synthesized in good-to-excellent yield, and the structures were ascertained with the help of (1) H NMR, (13) C NMR, mass, and elemental analysis. Among the tested series, compound 4i was identified as the most potent analog against the H1N1 virus, with IC50  = 5.

[Human survivin modified DCs vaccine inhibits laryngeal cancer in vivo and in vitro].

Objective: Construction of human full-length survivin gene-modified DCs vaccine and observe the biological characteristics and the role of laryngeal cancer treatment.

Methods: Construction of homologous recombination through the full-length survivin-human adenovirus (pAd-sur), and transfection of immature DCs, induced by access to sophisticated cultivate DCs, the proliferation of activated T lymphocytes; DCs vaccine different groups observed in vitro, in vivo biological activity.

Results: The success in bringing human to build a full-length survivin gene recombinant adenovirus vector pAd-sur; get with the typical characteristics of DCs, the expression level of the surface molecules of up to CD1a 46.

[Molecular characterization of hantavirus Zhejiang isolate ZT10 strain from M. fartis].

Objective: To learn about the complete genomic sequence of the Seoul virus strain ZT10 isolated from M. fartis.

Methods: The total RNA was extracted from the infected Vero E6 cells and amplified by RT-PCR.

[A case control study on the risk factors of male infertility].

Objective: To study the risk factors of male infertility.

Method: Case control study including 94 cases and control group with a ratio of 1 to 1.

Results: The risk factors of male infertility were long time heavy smoking habit (OR = 3.