Futility indications in resuscitative thoracotomy: A retrospective observational study evaluating practice guidelines.

Background: Resuscitative thoracotomies (RTs) are controversial interventions that heavily consume resources and can pose risks for the surgical team. Increasingly limited resources and risk to healthcare teams have encouraged the continued refinement of RT guidelines. We evaluated RT futility indicators amid institutional RT practice guideline changes.

Circular grafting combined for length gain in men after penile implant surgery.

Introduction: Acquired penile shortening has multiple possible causes, including Peyronie's disease, penile prosthesis (PP) removal, trauma, radical prostatectomy, and long-standing erectile dysfunction. If severe, it can preclude the ability to have intercourse. Multiple surgical techniques aimed at enhancing penile length have been described.

Longitudinal Monitoring of Lumacaftor/Ivacaftor Response in Young Children with Cystic Fibrosis Lung Disease Using Xe MRI.

Rationale And Objectives: Hyperpolarized Xe magnetic resonance imaging (MRI) can sensitively detect subtle abnormalities in subjects with pulmonary disease. In this work, we assess lung disease progression and treatment response to Lumacaftor/Ivacaftor in patients with cystic fibrosis.

Methods: 18 cystic fibrosis (CF) patients underwent a longitudinal study: nine subjects (8.

A Geometric Approach for the Comparison of Kinematic Synergy Postures.

The analysis of human movements has highlighted the presence of stereotyped coordination patterns among the different joints of the human body. These patterns are commonly referred to as kinematic synergies. Synergies have been used to both elucidate the underlying neuromotor control strategies adopted by humans during coordinated motion and inform the design and control of assistive and rehabilitative devices such as prostheses and exoskeletons.

Optimizing Cross-Modal Matching for Multimodal Motor Rehabilitation.

Stroke often causes sensorimotor deficits, impairing hand dexterity and disrupting independence for millions worldwide. While rehabilitation devices leveraging visual and haptic feedback show promise, their effectiveness is limited by a lack of perceptual equity, which is necessary to ensure fair comparisons between sensory modalities. This study refines cross-modal matching protocols to address this gap, enabling unbiased evaluation of multimodal feedback.

Developing Pharmaceutically Relevant Pd-Catalyzed C-N Coupling Reactivity Models Leveraging High-Throughput Experimentation.

This manuscript presents machine learning models for Pd-catalyzed C-N couplings constructed using a large, pharmaceutically relevant, structurally diverse dataset (4204 unique products) generated using high-throughput experimentation. The dataset generation was enabled by the discovery of novel nanomole scale compatible automation friendly C-N coupling reaction conditions using LiOTMS as the base. The large dataset enabled the systematic evaluation of model performance using five different data-splitting strategies that were carefully designed to assess the models' ability to both interpolate and extrapolate.

Gender Influences on Depression Severity in Patients With Urinary Incontinence.

Introduction Urinary incontinence is a prevalent lower urinary tract symptom (LUTS) that significantly impacts quality of life and poses a substantial healthcare burden. Concurrently, depression remains a major public health concern, contributing to disability and diminished well-being. While prior studies have documented a strong association between LUTS and depression, the extent to which gender differences modify this relationship remains unclear.

The use and performance of lyso-Gb3 for the diagnosis and monitoring of Fabry disease: A systematic literature review.

Background: Fabry disease (FD) is a rare, X-linked lysosomal storage disorder in which a lack of alpha-galactosidase (α-Gal A) enzyme activity leads to intracellular accumulation of deacylated globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3), and their analogs. Lyso-Gb3, present in the blood and urine of affected patients, has been extensively investigated as a biomarker for FD. This systematic literature review (SLR) aimed to comprehensively assess the use of lyso-Gb3 as a biomarker for screening, monitoring, and diagnosis of FD in both real-world and clinical trial settings.

Two decades of experience of the Fabry Outcome Survey provides further confirmation of the long-term effectiveness of agalsidase alfa enzyme replacement therapy.

Background: Analyses of up to 20 years of data from the Fabry Outcome Survey (FOS) assessed the long-term effectiveness of agalsidase alfa enzyme replacement therapy.

Methods: The impact of agalsidase alfa treatment on renal, cardiac, morbidity, and mortality outcomes in FOS was compared with untreated external Fabry disease (FD) cohorts.

Results: A total of 2171 FOS patients (1014 men, 919 women, 163 boys, 75 girls) received agalsidase alfa (median [range] duration of treatment: 5.

Explaining human motor coordination via the synergy expansion hypothesis.

The search for an answer to Bernstein's degrees of freedom problem has propelled a large portion of research studies in human motor control over the past six decades. Different theories have been developed to explain how humans might use their incredibly complex neuro-musculo-skeletal system with astonishing ease. Among these theories, motor synergies appeared as one possible explanation.

Variation in Outcomes Associated With Blunt Splenic Injury Management.

Introduction The management of blunt splenic injury has evolved to include splenic artery embolization in addition to non-surgical management, and splenic surgery. Though research has been conducted examining outcomes between management approaches, the inferential findings are often limited by single-site study designs and small sample sizes. However, results from large-scale prior studies can inform inference if a non-frequentist (Bayesian) framework is used.

Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke.

Globally, there are 15 million stroke patients each year who have significant neurological deficits. Today, there are no treatments that directly address these deficits. With demographics shifting to an older population, the problem is worsening.

When less is more: Short-Term efficacy of a gamified personalized normative feedback intervention for college students.

Despite various intervention efforts, college drinking remains a concern, and while personalized normative feedback (PNF) has proven effective, attempts to deliver it in a way that minimizes reactance and maximizes student engagement have been slow to emerge. This study examined the short-term effects of CampusGandr, a mobile gamified PNF intervention for college students. The game took place over 16 weeks (1 round per week) during the fall semester and included weekly PNF on various topics related to college life, including alcohol.

Lentivirus-mediated gene therapy for Fabry disease: 5-year End-of-Study results from the Canadian FACTs trial.

Background: Fabry disease is an X-linked lysosomal storage disorder due to a deficiency of α-galactosidase A (α-gal A) activity. Our goal was to correct the enzyme deficiency in Fabry patients by transferring the cDNA for α-gal A into their CD34+ hematopoietic stem/progenitor cells (HSPCs). Overexpression of α-gal A leads to secretion of the hydrolase; which can be taken up and used by uncorrected bystander cells.

Contemporary prostate cancer radiation therapy trials may underestimate the risk of biochemical recurrence.

Background: Radiotherapy is often given with androgen deprivation therapy for prostate cancer which causes a reduction in testosterone levels, which when below castrate levels, can cause the prostate specific antigen (PSA) levels to be artificially low.

Aim: To determine if high-level radiotherapy clinical trials are underestimating biochemical recurrence (BCR) rates due to inadequate measurement of testosterone levels.

Methods: The study plans for clinical trials performed by the Radiation Therapy Oncology Group (RTOG [now NRG]) on clinicaltrials.

Interventions to address empathy-based stress in mental health workers: A scoping review and research agenda.

Consistently engaging with client distress can negatively impact mental health workers (MHWs). This has been described by the concept of empathy-based stress (EBS) (which encompasses burnout; secondary traumatic stress; compassion fatigue and vicarious trauma). Previous reviews of interventions to reduce EBS have not addressed MHWs as a distinct group, despite evidence suggesting they are particularly vulnerable to it.

Pain associated with prostaglandin E-containing intracavernosal injection medication is associated with poor erectile function recovery after radical prostatectomy.

Background: Intracavernosal injection therapy is often used as second-line therapy for erectile dysfunction associated with radical prostatectomy when therapy with phosphodiesterase-5 inhibitors has failed, but prostaglandin E1-containing vasoactive agents are associated with penile pain in some men.

Objectives: To define the incidence of pain with prostaglandin E1-containing intracavernosal injection mixtures for erectile dysfunction associated with radical prostatectomy when therapy with phosphodiesterase-5 inhibitors has failed, and whether pain was a predictor of erectile function recovery.

Materials And Methods: Men who underwent radical prostatectomy and were commenced on intracavernosal injection within 12 months of radical prostatectomy were included.

Efficient use of penile Doppler ultrasound for investigating men with erectile dysfunction.

Background: Vasculogenic erectile dysfunction is the most common type of erectile dysfunction, and penile Doppler ultrasound (PDUS) is a useful tool to assess erectile hemodynamics in the clinician's effort to discuss prognosis and management strategies with the patient.

Aim: We herein describe the PDUS protocol used at our center, including indications, technique, and data interpretation.

Methods: We describe our institutional experience with PDUS and discuss it in the context of a contemporary review of the literature for this investigation.

Renal and multisystem effectiveness of 3.9 years of migalastat in a global real-world cohort: Results from the followME Fabry Pathfinders registry.

Fabry disease is a progressive, X-linked lysosomal disorder caused by reduced or absent α-galactosidase A activity due to GLA variants. The effects of migalastat were examined in a cohort of 125 Fabry patients with migalastat-amenable GLA variants in the followME Pathfinders registry (EUPAS20599), an ongoing, prospective, patient-focused registry evaluating outcomes for current Fabry disease treatments. We report annualised estimated glomerular filtration rate (eGFR) and Fabry-associated clinical events (FACEs) in a cohort of patients who had received ≥3 years of migalastat treatment in a real-world setting.

Safety and performance of conduction system pacing: Real-world experience from a product surveillance registry.

Background: Conduction system pacing (CSP), including His-bundle pacing (HBP) and left bundle branch area pacing (LBBAP), has been used as an alternative for pacemaker indicated patients requiring ventricular pacing.

Objective: The purpose of this study was to characterize the safety and performance of HBP and LBBAP among patients enrolled in the Medtronic product surveillance registry (PSR).

Methods: This observational analysis included patients who underwent pacemaker implantations for HBP or LBBAP with a Medtronic Model 3830 lead between January 2019 and December 2023 in the Medtronic PSR.

Ni-Catalyzed Reductive 1,2-Alkylarylation of Alkenes for the Synthesis of Spirocyclic γ-Lactams.

An intermolecular nickel-catalyzed reductive 1,2-alkylarylation of acrylates with cyclopropylamine NHP esters and aryl iodides is reported. This operationally simple protocol provides direct access to 1-alkylcyclopropylamine scaffolds. The mild conditions are compatible with four-membered α-amino strained rings as well as five- and six-membered ring systems.