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| http://dx.doi.org/10.1016/j.ymthe.2025.07.054 | DOI Listing |
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Risk of Relapse Post Reduced Intensity Conditioning Allogeneic Stem Cell Transplant in Patients With High-Risk Myeloid Neoplasms Based on GvHD Prophylaxis: PTCy Vs. TAC/MTX.
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Introduction: Recent advances in hematopoietic stem cell transplantation (HSCT) have improved clinical outcomes; however, various factors continue to influence HSCT success, especially vaccination in immunocompromised patients who receive vaccination at birth. While several studies have investigated the efficacy of vaccines in Chronic Granulomatous Disease (CGD) patients, the specific impact of vaccination on HSCT outcomes in these patients has not yet been studied. This study aimed to address an important gap in the current literature by investigating the effects of BCG vaccination on HSCT outcomes in patients with CGD.
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Reduced intensity conditioning (RIC) is usually used for patients with myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (allo-HCT), particularly in the elderly or those with comorbidities. The impact of conditioning intensity on patients' outcome remains controversial with clinicians' subjective opinion/ experience remaining a major guide in choosing the intensity. Here, we compare RIC versus MAC in a large EBMT retrospective study in MDS patients aged ≥50 years undergoing allo-HCT between 2014 and 2018.
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Presenting unpaired unconditional stimuli (US) during extinction has been shown to reduce the contextual renewal of conditional fear and to slow re-acquisition. The present study investigated whether this reduced return of fear is also observed if the intensity of the US presented during extinction is lower than that presented during acquisition. Three groups of participants (N = 121) were trained in a differential fear conditioning procedure that employed habituation, acquisition, extinction, renewal test, and re-acquisition phases.
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