Oxiracetam and physical activity in preventing cognitive decline after stroke: A multicenter, randomized controlled trial.

Introduction: This multicenter, double-blind, placebo-controlled trial, commissioned by South Korea's Ministry of Food and Drug Safety, evaluated the effect of oxiracetam for preventing post-stroke cognitive impairment (PSCI) and explored potential interaction with physical activity using neuroimaging.

Patients And Methods: Patients at high risk of PSCI, reporting subjective cognitive decline ⩾3 months after stroke, were randomized 1:1 to receive oxiracetam or placebo for 36 weeks. Physical activity was tracked via wrist-worn actigraphy.

Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management.

Hypertension is a major risk factor for stroke, and appropriate management of blood pressure (BP) is crucial for both prevention and treatment. Since the 2009 publication of the Clinical Practice Guideline (CPG) by the Korean Stroke Society (KSS), significant advances have been made in BP management for stroke patients, particularly in cases involving intracerebral hemorrhage and in the context of endovascular reperfusion therapy for ischemic stroke. In light of recent evidence, the CPG Committee of the KSS initiated an update of the guidelines for BP management in acute stroke.

Long-Term Outcomes and Predictors in Cancer-Related Stroke Using the Linked Data Set.

Background: Data on long-term prognostic factors in patients with cancer-related stroke are limited. The purpose of this study was to evaluate long-term outcomes and investigate prognostic factors of cancer-related stroke using a linked data set.

Methods: Between January 2008 and December 2014, patients with cancer-related stroke (n=690) were included in a linked data set comprising the Health Insurance Review and Assessment Service claims database and the Clinical Research Center for Stroke registry data.

Effectiveness and Safety of Endovascular Treatment in Large Vessel Occlusion Stroke with an NIHSS Score of ≤5 Exhibiting Predominant Cortical Signs.

: Our study aimed to evaluate the impact of EVT on stroke outcomes in patients with LVO with a National Institute of Health Stroke Scale (NIHSS) score of ≤5, exhibiting primarily cortical signs. : We conducted a multicenter registry-based analysis of patients with acute ischemic stroke with LVO who arrived within 12 h of onset. Among these, patients with low NIHSS scores and prominent cortical signs (Items 2, 3, 9, or 11) were included.

Diabetes status, duration and risk of dementia in patients with myocardial infarction.

Background: This study examines how diabetes mellitus (DM), specifically its diagnostic status and duration, influences dementia risk in individuals with a history of myocardial infarction (MI). We evaluated whether DM correlates with an increased incidence of all-cause dementia, as well as Alzheimer's disease (AD) and vascular dementia (VaD).

Methods: Utilizing from the Korean National Health Insurance Database (K-NHID), this retrospective cohort study included 43,561 patients with a history of MI but no prior dementia diagnosis, tracked from 2009 to 2018.

SMART-M24: A Prognostic Nomogram for Long-Term Mortality in Acute Ischemic Stroke Beyond 24 H from Symptom Onset.

Prognostication after acute ischemic stroke is crucial for long-term care plans. Although hyperacute management significantly affects outcomes, prognostic factors for patients receiving delayed care remain unknown. This study aimed to evaluate predictors and develop a method for estimating long-term mortality in patients with delayed hospital arrival 24 h after stroke symptom onset.

Temporal Trends in Public Stroke Awareness in Korea, 2009 to 2023.

Background: No large-scale survey on public stroke awareness has been conducted in Korea since 2009. This study assessed temporal trends in awareness of stroke warning signs (WSs) and risk factors (RFs) from 2009 to 2023. We hypothesized that stroke awareness remains inadequate and that changes in information sources have influenced the depth of knowledge.

Procedure Time of Endovascular Thrombectomy as Performance Measure of Acute Stroke Treatment.

Purpose: Procedure time (PT), defined as the time between groin access and vessel recanalization, is a recently recognized predictor of outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). However, the factors affecting PT and its potential value as a performance measure of AIS treatment remain unexplored.

Materials And Methods: Using the Korean Stroke Registry, we compared patients who underwent EVT for AIS from 2018 to 2022 based on 60 minutes PT.

Deep learning-based automatic segmentation of cerebral infarcts on diffusion MRI.

We explored effects of (1) training with various sample sizes of multi-site vs. single-site training data, (2) cross-site domain adaptation, and (3) data sources and features on the performance of algorithms segmenting cerebral infarcts on Magnetic Resonance Imaging (MRI). We used 10,820 annotated diffusion-weighted images (DWIs) from 10 university hospitals.

Temporal patterns of occult cancer incidence following acute ischemic stroke: A comparative study by stroke etiology.

Backgrounds And Aims: This study investigates the temporal patterns of occult cancer incidence among survivors of acute ischemic stroke (AIS), with a focus on variations by underlying stroke etiology.

Patients And Methods: We analyzed data from a prospective, multicenter stroke registry and a national claims database, identifying AIS patients hospitalized between 2011 and 2013. Patients were categorized by stroke etiology into two groups: unidentified stroke etiology (USE) and identified stroke etiology (ISE).

Persistent Beta-Blocker Therapy Reduces Long-Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates.

Background: Elevated heart rate in patients with acute ischemic stroke is associated with increased risk of mortality. Beta-blocker therapy is well known to reduce heart rate.

Methods And Results: This study was a post hoc analysis of patients with acute ischemic stroke with maximum heart rates ≥100 bpm.

Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry.

Background: This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade-long trend analysis, using data from a comprehensive, national, multicenter registry. We also seek to identify areas in need of improvement.

Methods And Results: This analysis involved patients with ischemic stroke or transient ischemic attack registered prospectively in the CRCS-K-NIH (Clinical Research Center for Stroke in Korea-National Institute of Health) registry between 2011 and 2020.

Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke.

Background And Purpose: Previous research on patients with acute ischemic stroke (AIS) has shown a 0.5% incidence of major gastrointestinal bleeding (GIB) requiring blood transfusion during hospitalization. The existing literature has insufficiently explored the long-term incidence in this population despite the decremental impact of GIB on stroke outcomes.

Comparative Effectiveness of Rosuvastatin Versus Atorvastatin in Acute Ischemic Stroke Treatment.

Background: Research specifically addressing the efficacy of rosuvastatin versus atorvastatin in patients with ischemic stroke is insufficient. Using a large stroke registry, we investigated whether 2 commonly used statins, rosuvastatin and atorvastatin, differ in their effectiveness in reducing the risk of vascular events in patients with acute ischemic stroke.

Methods: We analyzed data from a nationwide stroke registry in South Korea between January 2011 and April 2022.

Influence of prestroke glycemic status on outcomes by age in patients with acute ischemic stroke and diabetes mellitus.

Background: This study aimed to explore the association between admission HbA1c and the risk of 1-year vascular outcomes stratified by age group in patients with acute ischemic stroke (AIS) and diabetes mellitus (DM).

Methods: This study analyzed prospective multicenter data from patients with AIS and DM. Admission HbA1C were categorized as:≤6.

Risk of long-term post-stroke dementia using a linked dataset of patients with ischemic stroke without a history of dementia.

Background: Post-stroke dementia (PSD) is a common and disabling sequela of stroke. However, the long-term incidence of PSD after an ischemic stroke and factors which predict its occurrence are incompletely understood. Linkage of large health datasets is being increasing used to study long-term outcomes after disease.

Depression and risk of stroke and mortality after percutaneous coronary intervention: A nationwide population study.

Background: Limited evidence exists on the role of depression in the risk of developing stroke and other cardiovascular outcomes in patients who have undergone percutaneous coronary interventions (PCI). We investigated this relationship with data from the Korean National Health Insurance Service database.

Methods: Our nationwide retrospective cohort study included 164,198 patients who had undergone PCI between 2010 and 2017.

Temporal trends of sex differences in acute reperfusion therapy and early outcomes of acute ischemic stroke in South Korea: 10-year analysis of the nationwide stroke registry.

Background: Sex differences in stroke outcomes are notable, with women experiencing higher incidence rates, greater disability-adjusted life years, and poorer recovery compared to men, even after adjusting for age and comorbidities. Despite the disproportionate burden in women, studies have reported that women are less likely to receive appropriate stroke treatment than men.

Aim: This study investigated temporal trends of sex differences in acute reperfusion therapy and early outcomes in patients with acute ischemic stroke over 10 years in South Korea.

Optimal use of antithrombotic agents in recent small subcortical strokes accompanied by atrial fibrillation.

Background: This study aimed to evaluate the efficacy and safety of anticoagulants (AC) and antiplatelets (APT) in patients with recent small subcortical infarctions (RSSI) and atrial fibrillation (AF).

Methods: We utilized a prospective multicenter stroke registry database to identify patients with RSSI with a concurrent diagnosis of AF. Propensity score matching analysis was used to balance baseline differences among the AC-only, APT-only, and their combination groups.