Publications by authors named "Lokesh Kumar Saini"

Background: Many psychiatric disorders present with symptoms involving disordered sleep. The overlay of sleep and psychiatric disorders, though ubiquitous, remains less well understood. The evolution of diagnostic manuals for sleep and psychiatric disorders has also complicated our understanding of this intersection.

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Background: The clinical course and severity of restless legs syndrome (RLS) are variable. Existing questionnaires measure the severity of RLS based on recall. One possible solution could be the daily charting of symptoms in a diary.

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The perinatal period is a critical phase in a woman's life characterized by significant physical, emotional, and societal changes. Sleep disorders such as insomnia, restless legs syndrome, obstructive sleep apnea, and poor sleep quality have been observed to increase in prevalence during the perinatal period. Given the harmful impact of sleep disturbances on the health of both mother and newborn, it is crucial to diagnose and treat them promptly.

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Article Synopsis
  • - Patients with COPD have risk factors that also contribute to Restless Legs Syndrome (RLS), leading to a higher prevalence of RLS compared to the general population due to factors like chronic hypoxemia, anemia, and nicotine use.
  • - In a study of 210 stable COPD patients, 12.9% were diagnosed with RLS, with around half of those experiencing moderate to severe symptoms, and factors like younger age, female gender, and severe COPD were linked to higher odds of having RLS.
  • - The findings suggest that doctors should screen stable COPD patients who are younger, female, or have higher airflow limitation and serum creatinine for RLS, considering the notable impact of depressive symptoms in these individuals.
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Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a commonly performed procedure by the bronchoscopist for the evaluation of mediastinal lesions. However, evidence directly comparing the nasal and oral routes to guide the choice of an optimal insertion approach is scanty.

Methods: In this prospective, parallel-group, open-label randomized clinical trial, adults posted for a linear EBUS-TBNA examination under conscious sedation were randomized to undergo the procedure via the nasal or oral route.

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In this study, the dissipation kinetics and health risk assessment of different insecticides in tomato under open field and poly-house conditions were investigated. A total of four insecticides, namely Chlorantraniprole 18.5 SC @ 30 g a.

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Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an acute respiratory disease that can lead to respiratory failure and death. Although anticipated that patients with chronic respiratory diseases would be at increased risk of SARS-CoV-2 infection and more severe presentations of COVID-19, it is striking that these diseases appear to be underrepresented in the comorbidities reported for patients with COVID-19. The first wave of COVID-19 has taught us important lessons concerning the enormous burden on the hospitals, shortage of beds, cross infections and transmissions, which we coped together.

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Background: Sleep is important for maintaining the metabolic processes in the body, and hence, disruption in sleep leads to metabolic derangement and accelerated atherosclerosis. The effect of sleep duration on subclinical atherosclerosis has been examined in several studies; however, data regarding sleep quality is lacking. The study aimed to assess the association between sleep quality and carotid intima-media thickness among healthy young doctors.

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Article Synopsis
  • The study aimed to explore how SARS-CoV-2 infection affects sleep disorders, specifically insomnia, restless legs syndrome (RLS), and dream enactment behavior (DEB), highlighting a gap in existing literature.
  • Out of 1,596 participants, 37.2% reported disturbed sleep, with 22.6% experiencing insomnia, 27.3% RLS, and 17.4% DEB, with higher rates observed in males and those infected with SARS-CoV-2.
  • The findings suggest a significant association between SARS-CoV-2 infection and increased occurrences of these sleep disorders, particularly among those facing additional health challenges like oxygen therapy, loss of taste/smell, depression, and anxiety
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Background: An end to the novel coronavirus disease 2019 (COVID-19) pandemic appears to be a distant dream. To make matters worse, there has been an alarming upsurge in the incidence of cavitating invasive fungal pneumonia associated with COVID-19, reported from various parts of the world including India. Therefore, it remains important to identify the clinical profile, risk factors, and outcome of this group of patients.

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Background: The novel disseminated intravascular coagulation (DIC) score (platelet count, prolonged prothrombin time, D-dimer, and fibrinogen) and sepsis-induced coagulopathy (SIC) score (platelet count, international normalized ratio, and sequential organ failure assessment score) are markers of coagulopathy, which, for the first time, are explored in line with the coronavirus disease-2019 (COVID-19) disease outcomes. The correlation of D-dimer with these findings is also studied.

Materials And Methods: A retrospective analysis of hospital-based records of 168 COVID-19 patients was done.

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Observation of episodes of sleepwalking and prolonged partial sleep paralysis in the same patient is a rare condition. We present a case of 42 years gentleman who presented with recurrent episodes of sleepwalking and prolonged incomplete sleep paralysis. He was on tablet divalproate 1000mg/day and tablet olanzapine 5mg/day in view of a psychotic episode that occurred 4 years ago.

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Bronchoscopy is an extremely useful diagnostic and therapeutic procedure that finds an invaluable place in Pulmonology practice. Due to aerosol generation, bronchoscopy carries a high risk of infection transmission to health care workers and other patients. This fact is even more important in the present times of COVID-19 pandemic owing to its droplet- (and possibly aerosol-) mediated spread.

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Study Objectives: Like other medical branches, the practice of sleep medicine has been affected by the COVID-19 pandemic; however, the actual impact is not known. This study was planned to assess the status of the practice of sleep medicine in India during the COVID-19 pandemic and lockdown.

Methods: This was an online questionnaire-based descriptive study.

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This case is being reported to draw the attention of non-cardiac practicing physicians including pulmonologists, intensivists, and, as a matter of fact all primary care and emergency clinicians, towards a relatively uncommon ECG finding that could be the potential lead in suspecting the diagnosis of a commonly encountered, often fatal medical condition. Together with a high clinical index of suspicion, this alone could guide the decision-making process for further work-up and specific therapy.

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Sleep disorders often disturb sleep. Daytime symptoms of disturb sleep mimic that of depression, somatoform disorder, fibromyalgia and chronic fatigue syndrome. We are presenting a case of depression who was not responding to antidepressant therapy.

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Tuberculosis is a common disease but it keeps on surprising with its unique presentations. It has been reported as lung mass but here we are reporting a case of Tuberculosis presented as vasculitic lung mass. A 61 years old female, known case of hypertension and secondary Sjogren syndrome, on treatment, presented with history of mild dyspnea and generalised weakness with incidental finding of Right hilar mass on chest X-ray undergoes a CECT thorax and CT guided biopsy.

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