Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.

Objective: To evaluate the prevalence of pathogenic/likely pathogenic inherited cardiomyopathy variants and their association with heart failure in the (TOPMed) TransOmic for Precision of Medicine cohorts.

Methods: A retrospective cohort study using the TOPMed cohorts, including multi-ancestry US adults (≥18 years of age) with sequencing data, was conducted. Pathogenic/likely pathogenic inherited cardiomyopathy variant carrier status was determined based on ClinVar variants classified with two or more stars of evidence.

Pathophysiological and Etiological Corroborations for the Mechanistic Design of Intranasal Therapies in Glioblastoma Multiforme.

The quintessential hallmarks of brain malignancies hinge on their acquired biological traits, which encompass mutations in the epidermal growth factor receptor (EGFR), as well as vasculogenesis and cellular energy reprogramming. Glioblastoma multiforme (GBM) remains a prominent malignant form of brain tumor in humans. GBM patients exhibit a dismal prognosis with a median survival time of only 1-2 years due to the complex pathophysiology, the development of resistance by cancer cells, and the inability of therapeutic components to pass the blood-brain barrier (BBB) and blood-tumor barrier (BTB).

Comprehensive heavy metal remediation mechanisms with insights into CRISPR-Cas9 and biochar innovations.

Heavy metal contamination of the environment is a serious issue, and more efficient and effective bioremediation techniques are needed. This review introduces current heavy metal bioremediation techniques, with focus on phytoremediation and microbial remediation, and recent developments in biochar and CRISPR-Cas9 technology. Phytoremediation employs the natural process of plants to accumulate and detoxify metals as an eco-friendly and sustainable technique.

Cardiovascular Health and Outcomes in Carriers With Genetic Variants of Hypertrophic Cardiomyopathy.

Objective: To elucidate the interplay between genetic predisposition and cardiovascular health (CVH) factors in individuals with pathogenic or likely pathogenic variants in hypertrophic cardiomyopathy sarcomere-encoding genes (SARC-HCM-P/LP).

Methods: This retrospective cohort study used data from the UK Biobank, including 159,375 participants aged 40 to 69 years with whole exome sequencing data and no baseline cardiovascular disease. Participants were stratified into 2 groups based on the presence of SARC-HCM-P/LP variants (SARC-HCM-P/LP vs SARC-NEG).

Satisfaction of stakeholders with the government e-marketplace platform in a tertiary care hospital of northern India.

Background Automation of the procurement process through e-procurement is a key strategy for enhancing industrial operations management. E-procurement in the supply chain allows companies to use the internet to procure materials and handle value-added services. The Government of India, in the year 2016, introduced the government e-marketplace (GeM) for public sector procurement.

Association of Pathogenic/Likely Pathogenic Genetic Variants for Cardiomyopathies With Clinical Outcomes: A Multiancestry Analysis in the All of Us Research Program.

Background: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes.

Methods: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomyopathy genes were identified using the ClinVar database.

Antimicrobial prescription patterns in tertiary care centres in India: a multicentric point prevalence survey.

Background: Antimicrobial resistance (AMR) poses a global health threat, emphasizing the need for Point Prevalence Surveys (PPS) to understand antibiotic use and resistance. This study assesses antibiotic use patterns and resistance in tertiary care hospitals across India to inform AMR interventions.

Methods: This cross-sectional survey was conducted over two weeks between May and August 2023 in eight Indian tertiary care hospitals.

Differences in natriuretic peptide response in self-identified white and black individuals: a physiological clinical trial.

Black individuals have lower plasma natriuretic peptide (NP) concentrations than white individuals. However, race-based differences in the NP response to physiological perturbations are unknown. In this physiological trial (NCT#03070184), we measured the NP [mid-regional atrial NP (MR-proANP), N-terminal pro-B-type NP (NT-proBNP), and BNP] response to physiological perturbations among healthy, self-identified Black and white participants aged 18-40 years.

2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.

Background: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).

Methods: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.

Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study.

Objective: We aimed to assess risk of COVID-19 infection & seroprotection status in healthcare workers (HCWs) in both hospital and community settings following an intensive vaccination drive in India.

Setting: Tertiary Care Hospital.

Methods: We surveyed COVID-19 exposure risk, personal protective equipment (PPE) compliance, vaccination status, mental health & COVID-19 infection rate across different HCW cadres.

Dietary Inflammatory Score and Incident Heart Failure in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

Background: Inflammation plays a key role in the development of heart failure (HF), and diet is a known modifiable factor that modulates systemic inflammation. The dietary inflammatory score (DIS) is a tool that quantifies the inflammatory components of diet. We sought to determine whether the DIS is associated with incident HF events.

PREVENT and Pooled Cohort Equations in Mortality Risk Prediction: National Health and Nutrition Examination Survey.

Background: The Predicting Risk of CVD Events (PREVENT) equations were developed to address limitations of the Pooled Cohort Equations (PCEs) in predicting atherosclerotic cardiovascular disease (ASCVD) risk. The comparative effectiveness of the PREVENT equations versus the PCEs in predicting mortality risk remains unknown.

Objectives: The purpose of this study was to compare the risk discrimination value of the PREVENT equations with the PCEs for predicting mortality.

Differences in Statin Eligibility With the Use of Predicting Risk of Cardiovascular Disease EVENTs Versus Pooled Cohort Equations in the UK Biobank.

The Pooled Cohort Equations (PCEs), developed by the American Heart Association (AHA) and American College of Cardiology, have been widely used since 2013 to estimate 10-year atherosclerotic cardiovascular disease (ASCVD) risk and guide statin therapy. Recently, the AHA introduced the Predicting Risk of CVD EVENTs (PREVENT) equations to improve ASCVD risk estimation. However, the effect of using PREVENT instead of PCEs on risk classification and statin eligibility remains unclear.

Unhindered Access to Hospital Buildings: A Neglected Domain.

Globally, 15% of the population suffers from disability. However, the percentage of people visiting hospitals who may be suffering from some form of disability may be higher. It may cause difficulty in accessing the health-care facilities.

Sex-Associated Differences in Clinical Outcomes After Septal Reduction Therapies in Hypertrophic Cardiomyopathy.

Objective: To evaluate sex-associated differences in the short- and long-term outcomes of patients with hypertrophic cardiomyopathy (HCM) undergoing septal myectomy and alcohol septal ablation.

Methods: This retrospective cohort study used electronic health record data from the TriNetX research database. International Classification of Diseases, Ninth Revision and Tenth Revision diagnosis and procedure codes were used to identify patients with HCM who underwent septal myectomy and alcohol septal ablation in the United States between January 2002 and March 2023.

Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers.

Background: Nearly 3% to 4% of Black individuals in the United States carry the transthyretin V142I variant, which increases their risk of heart failure. However, the role of cardiovascular (CV) risk factors (RFs) in influencing the risk of clinical outcomes among V142I variant carriers is unknown.

Objectives: This study aimed to assess the impact of CV RFs on the risk of heart failure in V142I carriers.

Procedural Volume and Outcomes After Septal Reduction Therapies in Hypertrophic Obstructive Cardiomyopathy.

Background: Septal myectomy and alcohol septal ablation (ASA) are septal reduction therapies for patients with symptomatic obstructive hypertrophic cardiomyopathy. Operator and hospital volume may influence outcomes, but contemporary data on this relationship are limited.

Methods And Results: This retrospective cohort study used data from the Vizient Clinical Data Base (2016-2022).