Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway.

Objective: To investigate the mechanism of induction of ferroptosis by brazilin in breast cancer cells.

Methods: Breast cancer 4T1 cells were divided into 6 groups: control, brazilin 1/2 half maximal inhibitory concentration (IC), IC, 2×IC, erastin (10 µg/mL) and capecitabine (10 µg/mL) groups. The effect of brazilin on the proliferation of 4T1 cells was detected by cell counting kit-8 assay, and the treatment dose of brazilin was screened.

Copper(II)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm.

Bacterial biofilm infection is a serious obstacle to clinical therapeutics. Photodynamic therapy (PDT) plays a dynamic role in combating biofilm infection by utilizing reactive oxygen species (ROS)-induced bacterial oxidation injury, showing advantages of mild side effects, spatiotemporal controllability and little drug resistance. However, superfluous glutathione (GSH) present in biofilm and bacteria corporately reduces ROS levels and seriously affects PDT efficiency.

A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection.

Bacterial biofilm-associated infectious diseases remain serious menaces to human health. Recently, photodynamic therapy (PDT) has become a prospective strategy for combating biofilm infection. However, anaerobic conditions in a biofilm greatly inhibit its therapeutic efficacy.

Optimizing triangle mesh lenses for non-uniform illumination with an extended source.

Precise control of irradiance distribution is a complicated problem for freeform lens design, especially when the target is non-uniform. Realistic sources are often simplified as zero-etendue ones in cases designed for content-rich irradiance fields while the surfaces are usually assumed smooth everywhere. These practices can limit the performance of the designs.

Investigating deep optics model representation in affecting resolved all-in-focus image quality and depth estimation fidelity.

The end-to-end (E2E) optimization of optics and image processing, dubbed deep optics, has renewed the state-of-the-art in various computer vision tasks. However, specifying the proper model representation or parameterization of the optical elements remains elusive. This article comprehensibly investigates three modeling hypotheses of the phase coded-aperture imaging under a representative context of deep optics, joint all-in-focus (AiF) imaging and monocular depth estimation (MDE).

An Energy Efficient Design of Computation Offloading Enabled by UAV.

The data volume is exploding due to various newly-developing applications that call for stringent communication requirements towards 5th generation wireless systems. Fortunately, mobile edge computing makes it possible to relieve the heavy computation pressure of ground users and decrease the latency and energy consumption. What is more, the unmanned aerial vehicle has the advantages of agility and easy deployment, which gives the unmanned aerial vehicle enabled mobile edge computing system opportunities to fly towards areas with communication demand, such as hotspot areas.

Energy-Efficient UAV-Enabled MEC System: Bits Allocation Optimization and Trajectory Design.

The unmanned aerial vehicle (UAV) enabled mobile edge computing (MEC) system is attracting a lot of attentions for the potential of low latency and low transmission energy consumption, due to the advantages of high mobility and easy deployment. It has been widely applied to provide communication and computing services, especially in Internet of Things (IoT). However, there are still some challenges in the UAV-enabled MEC system.

Dynamic Speed Control of Unmanned Aerial Vehicles for Data Collection under Internet of Things.

With the new advancements in flight control and integrated circuit (IC) technology, unmanned aerial vehicles (UAVs) have been widely used in various applications. One of the typical application scenarios is data collection for large-scale and remote sensor devices in the Internet of things (IoT). However, due to the characteristics of massive connections, access collisions in the MAC layer lead to high power consumption for both sensor devices and UAVs, and low efficiency for the data collection.

N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin.

The gene product of SPINT 2, that encodes a transmembrane, Kunitz-type serine protease inhibitor independently designated as HAI-2 or placenta bikunin (PB), is involved in regulation of sodium absorption in human gastrointestinal track. Here, we show that SPINT 2 is expressed as two species of different size (30-40- versus 25-kDa) due to different N-glycans on Asn-57. The N-glycan on 25-kDa HAI-2 appears to be of the oligomannose type and that on 30-40-kDa HAI-2 to be of complex type with extensive terminal N-acetylglucosamine branching.