Ice-Templating Derived High-Performance Layered Bulk Polymer Nanocomposites.

Inspired by nacre's hierarchical "brick-and-mortar" architecture, ice templating has emerged as a frontier technique for fabricating layered bulk polymer nanocomposites. This review systematically explores the innovative theories and technological advancements in the fabrication of layered bulk polymer nanocomposites via ice templating from a structure-property-application perspective. First, it focus on elucidating three core construction strategies enabled by ice templating: lamellar scaffold infiltration with polymers, hot-pressing, and mineralization.

Heterointerface-Engineered SiC@SiO@C Nanofibers for Simultaneous Microwave Absorption and Corrosion Resistance.

To meet the demands of maritime defense and transportation, next-generation microwave absorption (MA) materials must combine efficient attenuation and corrosion resistance (CR). SiC nanofibers, with their moderate dielectric constant and chemical inertness, are ideal multifunctional coating fillers. However, their single-component nature limits microwave attenuation, resulting in low efficiency and narrow bandwidth.

Ticagrelor increases peripheral 5-HT content by up-regulating the tryptophan hydroxylase 1 and down-regulating the serotonin transporter.

Ticagrelor, a reversible P2Y12 receptor antagonist, is the first-line recommended antiplatelet agent for acute coronary syndrome. Despite its widespread use, 13.8 % of patients report dyspnea, a side effect not fully understood but potentially linked to elevated levels of 5-hydroxytryptamine (5-HT, or serotonin) associated with tracheal constriction.

Effects of expressive writing on drug craving and symptoms of anxiety and depression in Chinese community-based drug use disorder rehabilitation: A randomized controlled trial.

The aim of this study was to assess the effects of expressive writing on drug craving and symptoms of anxiety and depression among Chinese patients experiencing community-based drug use disorder rehabilitation. It was a multicenter, single-blind, randomized controlled trial. A total of 153 participants were recruited and provided with a 4-week intervention.

Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats.

Interbody fusion devices are critical in spinal surgery to restore spinal stability, reduce pain and improve function. Polyetheretherketone (PEEK) has become a commonly used alternative material for fusion cages owing to its excellent mechanical properties and biocompatibility, but its biological inertness limits bone regeneration and may lead to poor fusion. In this study, a novel strategy for preparing bioactive biomineralized PEEK cages was developed using a unique combination of osteoinductive CaP bioceramic fillings in the cage window, acid sulfonation and simulated body fluid incubation.

Predicting high-need high-cost pediatric hospitalized patients in China based on machine learning methods.

Rapidly increasing healthcare spending globally is significantly driven by high-need, high-cost (HNHC) patients, who account for the top 5% of annual healthcare costs but over half of total expenditures. The programs targeting existing HNHC patients have shown limited long-term impact, and research predicting HNHC pediatric patients in China is limited. There is an urgent need to establish a specific, valid, and reliable prediction model using machine-learning-based methods to identify potential HNHC pediatric patients and implement proactive interventions before high costs arise.

Deep learning-assisted screening and diagnosis of scoliosis: segmentation of bare-back images via an attention-enhanced convolutional neural network.

Background: Traditional diagnostic tools for scoliosis screening necessitate a substantial number of specialized personnel and equipment, leading to inconvenience that can result in missed opportunities for early diagnosis and optimal treatment. We have developed a deep learning-based image segmentation model to enhance the efficiency of scoliosis screening.

Methods: A total of 350 patients with scoliosis and 108 healthy subjects were included in this study.

MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity.

Background: The development of chimeric antigen receptor (CAR)-T cell therapies for solid tumors has attracted considerable attention, yet their clinical efficacy remains limited. Therefore, various efforts have been made to improve the efficacy of CAR-T cell therapy. As one promising strategy, incorporating the T-cell receptor (TCR) machinery into CAR structures has been reported to improve the efficacy of CAR-T cells in studies using conventional CARs targeting such as EGFR.

Assessing differences among persistent, episodic, and non- high-need high-cost hospitalized children in China after categorization by an unsupervised learning algorithm.

Background: High-need, high-cost (HNHC) patients are a major focus of international healthcare reform. However, research on HNHC children in China remains limited. This study aims to classify HNHC pediatric patients, analyze the differences among groups, and explore the factors influencing HNHC status.

Constructing a Predictive Model for Psychological Distress of Young- and Middle-Aged Gynaecological Cancer Patients.

Background: Cancer patients experience substantial psychological distress which causes the reduction of the quality of life. However, the risk of psychological distress has not been well predicted especially in young- and middle-aged gynaecological cancer patients. This study aimed to develop a prediction model for psychological distress in young- and middle-aged gynaecological cancer patients using the artificial neural network (ANN).

Comparative Metabolome Profiling for Revealing the Effects of Different Cooking Methods on Glutinous Rice Longjing57 ( L. var. ).

Glutinous rice (GR), an important food crop in Asia, provides prolonged energy for the human body due to its high amylopectin content. The non-volatile metabolites generated by different cooking methods that affect the nutritional value and color of GR are still poorly understood. Herein, a widely targeted metabolomics approach was used to understand the effects of different cooking methods (steaming, baking, and frying) on the metabolite profiles of GR.

Preparation of hyperbranched hydrophobic nano-silica and its superior needling-effect in PDMS defoam agent.

Hydrophobic nano silica powder is a kind of important synergist to silicone defoaming agents. The large pore volume and branched chain conformation of silica nanoparticles present superior effects on defoaming properties. However, silica nanoparticles synthesized by liquid phase easily aggregate and pore collapse because of their high surface activity and polarity, leading to poorer dispersity and limited practicability.

Wide band gap selenide infrared nonlinear optical materials AMgGaSe with strong SHG responses and high laser-induced damage thresholds.

Infrared (IR) nonlinear optical (NLO) materials with strong NLO response, wide band gap and high laser-induced damage threshold (LIDT) are highly expected in current laser technologies. Herein, by introducing double alkaline-earth metal (AEM) atoms, three wide band gap selenide IR NLO materials AMgGaSe (A = Ca, Sr, Ba) with excellent linear and NLO optical properties have been rationally designed and fabricated. AMgGaSe (A = Ca, Sr, Ba) are composed of unique [ASe] triangular prisms, [MgSe] octahedra and [GaSe] tetrahedra.

Associations of fasting plasma glucose with all-cause mortality and cardiovascular events in older Chinese diabetes patients: A population-based cohort study.

Aims/introduction: Our aim was to investigate the optimal fasting glucose (FPG) range in Chinese older adults with type 2 diabetes, and to clarify whether the optimal range varies according to the control of risk factors.

Materials And Methods: The baseline survey for the cohort study began in 2018, with follow up ending in 2022. Our study enrolled 59,030 older diabetes patients with no history of cardiovascular disease (CVD).

Research on the zero-calibration gauge device.

To meet the demand for the track's geometric parameter detection equipment for train speed and high-speed aerodynamics tests, a zero-calibration gauge device is designed with the centering limit, height adjustment and horizontal display function in this paper. The bending situation of the zero-calibration gauge is analyzed and the processing technology is studied, which ensures the rationality and realizability of the design of zero-calibration gauge. Then the gauge zero value and the parallelism of the working surface of zero-calibration gauge have been experimentally tested.

Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4/HLA-A∗02:01 complex.

Despite the revolutionary success of chimeric antigen receptor (CAR)-T therapy for hematological malignancies, successful CAR-T therapies for solid tumors remain limited. One major obstacle is the scarcity of tumor-specific cell-surface molecules. One potential solution to overcome this barrier is to utilize antibodies that recognize peptide/major histocompatibility complex (MHCs) in a T cell receptor (TCR)-like fashion, allowing CAR-T cells to recognize intracellular tumor antigens.

Research Misconduct Investigations in China's Science Funding System.

As stewards of public money, government funding agencies have the obligation and responsibility to uphold the integrity of funded research. Despite an increasing amount of empirical studies examining research-related misconduct, a majority of these studies focus on retracted publications. How agencies spot funding-relevant wrongdoing and what sanctions the offenders face remain largely unexplored.

Simple preparation of lignosulfonate stabilized eutectic gallium/indium liquid metal nanodroplets through ball milling process.

The combination of biomass and liquid metal (LM) makes the preparation process "greener" and application of LM composite materials more sustainable. Here we reported the solvent free preparation of lignosulfonate (LS) stabilized eutectic gallium/indium (EGaIn) LM nanodroplets through ball milling (BM), which was recognized to be efficient and environmentally-friendly alternatives to solution-based methods. By regulating the BM frequency and milling time, uniform LM nanodroplets with a size <200 nm can be achieved.

Ba(BS)(PS): the first alkaline-earth metal thioborate-thiophosphate with strong optical anisotropy originating from planar [BS] units.

The first alkaline-earth metal thioborate-thiophosphate Ba(BS)(PS) was designed from Ba(BO)(PO) by S-O substitution and fabricated experimentally. The [BS] pseudo-layers formed in the structure contribute to the strong optical anisotropy and a large birefringence of ∼0.11 at 1064 nm.

Synthesis, structure and characterization of CdTeOCl with unprecedented [CdOCl] octahedral dimers.

A new mixed anionic compound CdTeOCl with unprecedented [CdOCl] octahedral dimers has been synthesized, and millimeter-scale single crystals of CdTeOCl have been grown by the vertical Bridgman method with CdCl as the flux. CdTeOCl crystallizes in the centrosymmetric 1̄ (no. 2) space group, and shows a mixed cationic layer structure constituted by distorted [TeO] motifs, mixed anionic [CdOCl] chains, and [CdOCl] octahedral dimers.

Involvement of iNOS-induced reactive enteric glia cells in gastrointestinal motility disorders of postoperative Ileus mice.

Postoperative ileus (POI) is the cessation or reduction of gastrointestinal (GI) motility after surgery. Reactive enteric glial cells (EGCs) are critical for maintaining bowel function. However, the triggering mechanisms and downstream effects of reactive EGCs in POI were poorly understood.