Optical segmentation-based compressed readout of neuronal voltage dynamics.

Functional imaging of biological dynamics generally begins with acquiring time-series images, followed by quantifying spatially averaged intensity traces for the regions of interest (ROIs). The conventional pipeline discards a substantial portion of the acquired data when quantifying intensity traces, indicative of inefficient data acquisition. Here we propose a conceptually novel acquisition pipeline that assigns each ROI to a single pixel in the detector, enabling optimally compressed acquisition of the intensity traces.

Explainable machine learning prediction of internet addiction among Chinese primary and middle school children and adolescents: a longitudinal study based on positive youth development data (2019-2022).

Background: Internet Addiction (IA) has emerged as a critical concern, especially among school age children and adolescents, potentially stalling their physical and mental development. Our study aimed to examine the risk factors associated with IA among Chinese children and adolescents and leverage explainable machine learning (ML) algorithms to predict IA status at the time of assessment, based on Young's Internet Addiction Test.

Methods: The longitudinal data consisting of 8,824 schoolchildren from the Chengdu Positive Child Development (CPCD) survey were analyzed, where 33.

Early childhood trauma and its long-term impact on cognitive and emotional development: a systematic review and meta-analysis.

Background: Childhood trauma has profound, long-term effects on cognitive and emotional development. This systematic review and meta-analysis sought to synthesis the evidence around the long-term impact of human childhood trauma on domains of cognition and emotion in order to inform interventions and public health strategies.

Methods: We systematically reviewed 465 studies from PubMed, Cochrane Library, and Google Scholar, 9 studies were included after duplicates were removed and inclusion and exclusion criteria were applied, and all 9 studies were aimed at low-income people in the United States.

Caspase-11 deficiency ameliorates elastase-induced abdominal aortic aneurysm in mice by suppressing inflammatory response of macrophages.

Abdominal aortic aneurysm (AAA) is a life-threatening, inflammation-related vascular disease lacking specific drugs. Murine caspase-11 (CASP11, its human orthologs CASP4/CASP5) is the major component of the noncanonical inflammasome. However, the role of CASP11 in AAA remains unknown.

Reducing Postpyloric Feeding Start Times in Patients With Large Hemispheric Infarction Receiving Therapeutic Hypothermia.

Background: Early postpyloric feeding provides effective and safe enteral nutrition for patients with large hemispheric infarction receiving therapeutic hypothermia.

Local Problem: Patients with large hemispheric infarction undergoing therapeutic hypothermia often have gastrointestinal dysfunction and undergo repeated bedside attempts at blind postpyloric feeding tube placement. Confirming tube position via radiography can delay nutrient intake, increase costs, and expose patients to unnecessary radiation.

Palladium-catalyzed intermolecular asymmetric dearomatizative arylation of indoles and benzofurans.

Indoles represent one of the most robust and synthetically versatile classes of heteroaromatic compounds. However, the stereoselective conversion of planar indole rings into three-dimensional indoline skeletons bearing multiple stereogenic centers remains a persistent challenge in organic synthesis. Herein, we describe an intermolecular catalytic asymmetric dearomatization of simple indoles via a palladium-catalyzed three-component cross-coupling reaction.

Norgestrel shows androgenic properties and triggers reproductive neuroendocrine toxicity in the testes of Pacific oysters (Crassostrea gigas).

Norgestrel (NGT), a prevalent progestin in the aquatic environment, can pose risks to vertebrates even at very low concentrations (<1 ng/L). Nevertheless, the understanding of NGT's effects on invertebrates is limited. Therefore, through histology and multi-omics, we explored the toxic effects of NGT (0, 10, and 1000 ng/L) on Pacific oysters Crassostrea gigas testes over 21 days.

Feasibility of whey protein powder supplementation in patients who are neurocritically ill: A post hoc analysis of a pilot randomized controlled trial.

Background: Hypoalbuminemia, often induced by acute stress and inflammation in patients who are neurocritically ill, is adversely associated with prognosis. This study investigates whether supplementing nutrition support with anti-inflammatory whey protein powder formulations (experimental group) can improve serum albumin levels and overall patient outcomes compared with traditional liquid intact protein formulations (control group) while monitoring for enteral feeding complications and inflammatory markers.

Methods: In a randomized controlled trial conducted at a neurointensive care unit from January 2020 to May 2022, 116 out of 597 patients who required enteral nutrition (EN) for at least 7 days were randomly assigned to receive either the formula from experimental group or control group.

RVG engineered extracellular vesicles-transmitted miR-137 improves autism by modulating glucose metabolism and neuroinflammation.

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder. The microglia activation is a hallmark of ASD, which involves increased glycolysis. Elevated glycolysis regardless of oxygen availability, known as "Warburg effect", is crucial to pathogenesis in neuropsychiatric disorders.

Longitudinal network analysis of depression, anxiety, and post-traumatic stress disorder comorbidities among adolescents in regional China.

Purpose: The network theory of mental disorders offers a new perspective for the understanding of comorbidities, but the research on the comorbidities among depression, anxiety, and post-traumatic stress disorder (PTSD) is still insufficient. The aim of this study was to explore the internal relationship by establishing and analyzing the comorbidity networks, and to provide suggestions for the intervention after traumatic events.

Methods: We utilized data from the second and third wave of the Chengdu Positive Child Development cohort ( = 3,189, 47.

Predicting responses of neuromodulation and psychotherapies for major depressive disorder: A coordinate-based meta-analysis of functional magnetic resonance imaging studies.

This meta-analysis synthesized resting-state functional connectivity (FC) patterns associated with treatment responses in Major Depressive Disorder (MDD). We evaluated studies from 2013 to 2023 that reported pre-treatment FC (i.e.

The resting-state brain activity and connectivity mediates the effect of overt narcissism on negative physical self.

Overt narcissism is a stable personality trait in which individuals maintain a relatively positive self-image through self-improvement. Previous studies have suggested that examining the neurobiological processes behind personality could help to understand the mechanism by which the personality acts as a risk or protective factor. However, there is a lack of research investigating the neural mechanisms underlying the influence of overt narcissism on negative physical self (NPS).

Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction.

Neuroinflammation triggered by microglia activation is hallmark of autism spectrum disorder (ASD), and this process includes crucial metabolic reprogramming from oxidative phosphorylation to glycolysis, which may cause neuron loss and functional impairment. The inhibitory immune checkpoint programmed cell death protein 1 (PD-1) on immune cells is an important target for tumor immunotherapy. However, the immunomodulatory effects of PD-1 in ASD remains to be elusive.

Sulfonylurea drugs for people with severe hemispheric ischemic stroke.

Background: Large hemispheric infarction (LHI), caused by occlusion of the internal carotid or middle cerebral artery, is the most malignant type of supratentorial ischemic stroke. Due to severe intracranial edema, mortality fluctuates between 53% and 78%, even after the most effective medical treatment. Decompressive craniectomy can reduce mortality by approximately 17% to 36%, but the neurological outcomes are not satisfactory, and there are contraindications to surgery.

Potential Delayed Positive Effects of tDCS on Improving Introspective Accuracy in Social Cognition in Schizophrenia.

Background And Hypothesis: Impairments in introspective accuracy (IA) are prominent among schizophrenia patients and detrimentally affect daily functioning, making IA a potential therapeutic target. Recent research highlights the role of the right rostrolateral prefrontal cortex (rlPFC) in IA and suggests that transcranial direct current stimulation (tDCS) to this region may improve it. Therefore, we tested whether applying tDCS to the right rlPFC could enhance IA for schizophrenia patients and explored the potential order/delayed effects.

Small Cell Lung Cancer with Dual Paraneoplastic Syndromes: A Case Report.

Introduction: Paraneoplastic syndromes are common in cancers such as lung, breast, and ovarian cancers. Still, the dual paraneoplastic syndromes of ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) and raised pancreatic enzymes at the same time are rare. EAS is due to the production of ACTH by tumors other than the pituitary gland, which stimulates the hyperplasia of the adrenal cortex to secrete excessive corticosteroids, most commonly in lung cancer.

Advanced One-Pot RPA-CRISPR/Cas12a Reaction with Glycerol and Betaine for High-Sensitivity Diagnosis of -Carrying Strains in Clinical Samples.

The gene confers methicillin resistance in both MRSA and MR-CoNS by encoding the PBP2a protein and poses a significant public health threat due to its resistance to beta-lactam antibiotics. Rapid and accurate detection of is critical for timely treatment, reducing morbidity, and preventing its spread in healthcare settings. In this study, we developed an advanced one-pot recombinase polymerase amplification (RPA)-CRISPR/Cas12a system, enhanced with glycerol and betaine, for ultrasensitive detection of the gene.

remodels the tumor microenvironment and promotes immune escape through enhancing tumor stemness and modulating the fibrinogen beta chain-neutrophil extracellular trap signaling axis in lung adenocarcinoma.

Background: Despite the recent advancements in the treatment of cancer, the 5-year survival of patients with non-small cell lung cancer (NSCLC) remains unsatisfactory. Lung adenocarcinoma (LUAD) is NSCLC's most common subtype, and metastasis is the major cause of death in patients with cancer. Therefore, identifying novel targets associated with metastasis in NSCLC is crucial to improving treatment.

Transcranial Direct Current Stimulation Improves Paranoia and Social Functioning in Schizophrenia: A Randomized Clinical Trial.

Background: Innovative treatments for paranoia, which significantly impairs social functioning in schizophrenia spectrum disorders (SSDs), are urgently needed. The pathophysiology of paranoia implicates the amygdala-prefrontal cortex (PFC) circuits; thus, in this study, we systematically investigated whether transcranial direct current stimulation (tDCS) to the ventrolateral PFC can attenuate paranoia and improve social functioning in SSDs.

Methods: A double-blind, within-subjects, crossover design was used to compare active versus sham tDCS effects in 50 participants with SSDs (ClinicalTrials.

Comparative analysis of warm needle moxibustion and gua sha nursing care on sleep quality and psychological stress in insomnia patients undergoing eszopiclone tablet treatment: A retrospective study.

This retrospective study aims to assess the adjunctive efficacy of warm needle moxibustion and gua sha care in the treatment of eszopiclone tablets on sleep quality and psychological stress in insomnia patients. Data of 138 insomnia patients from Gansu Baoshihua hospital between January and December 2022 were collected. Patients were bifurcated into 2 groups: those solely treated with eszopiclone (n = 71) and those administered a combined regimen of eszopiclone, warm needle moxibustion, and gua sha (n = 67).

Constructing dendrite-suppressing separators based on cellulose acetate and polyoxometalates toward uniform lithium electrodeposition.

Functionalized separators are expected to serve as protective barriers to conquer the lithium dendrite penetration in lithium metal batteries. Herein, a novel self-supporting separator material has been successfully synthesized based on the cellulose acetate and Keggin-type polyoxometalate HPMoO·HO (denoted as CA/PMo). The incorporation of PMo facilitates the transformation of the original finger-like structure of the CA separator into a uniform three-dimensional porous grid architecture, which is more effective in inhibiting the growth of lithium dendrites.

Perceived social support and deviant behavior of new street corner youth on campus: a moderated mediation model.

Introduction: The current study aimed to examine the moderated mediation between perceived social support, the deviant behavior of new street corner youth on campus (NSCYC), interpersonal needs (as a mediator), and meaning in life (as a moderator).

Methods: A total of 596 new street corner youth on campus were investigated using the Deviant Behavior Questionnaire, Perceived Social Support Scale, Interpersonal Needs Questionnaire, and Meaning in Life Questionnaire.

Results: The findings showed that: (1) perceived social support significantly and negatively predicted deviant behavior; (2) interpersonal needs mediated the association between perceived social support and deviant behavior; and (3) a moderated mediating role of perceived social support influencing deviant behavior was established, with meaning in life regulating both the direct and the first half paths of the model.

Targeted protein degradation via cellular trafficking of nanoparticles.

Strategies that selectively bind proteins of interest and target them to the intracellular protein recycling machinery for targeted protein degradation have recently emerged as powerful tools for undruggable targets in biomedical research and the pharmaceutical industry. However, targeting any new protein of interest with current degradation tools requires a laborious case-by-case design for different diseases and cell types, especially for extracellular targets. Here we observe that nanoparticles can mediate specific receptor-independent internalization of a bound protein and further develop a general strategy for degradation of extracellular proteins of interest by making full use of clinically approved components.

Delivery of liquid metal particles and tanshinone IIA into the pericardial cavity for myocardial infarction treatment.

Owing to their inherent flexibility and excellent biocompatibility, liquid metals (LMs) have been explored at the frontiers of clinical therapy. Herein, a LM and tanshinone IIA (TA) drugs were dispersed into sodium alginate (SA) solution by ultrasonication to prepare SA/LM/TA, which is an injectable biomaterial for stable drug release and intrapericardial injection for the treatment of myocardial infarction (MI). The SA/LM/TA has a low viscosity and can be injected smoothly using a syringe.