Assessment of established prognostic factors and artificial intelligence-based evaluation of tumor-infiltrating lymphocytes in oral tongue squamous cell carcinoma.

Background: Traditional risk assessment for tongue cancer relies on clinicopathological parameters. Although tumor-infiltrating lymphocytes (TILs) are promising prognostic markers, their evaluation lacks standardization. This study aimed to validate established prognostic factors and introduce an artificial intelligence (AI)-based TIL assessment method.

Primary Merkel cell carcinoma of the salivary gland: a clinicopathologic study of four cases with a review of literature.

Background: Primary Merkel cell carcinoma of the salivary gland is currently not listed in the World Health Organization classification. However, cases of Merkel cell type neuroendocrine carcinomas of the salivary gland with perinuclear cytokeratin 20 positivity have been intermittently reported. We here investigated the clinicopathologic features of additional cases.

Association Between the Histological Subtypes, Anatomical Locations, and MAML2 Rearrangement of Head and Neck Mucoepidermoid Carcinoma.

Purpose: Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. MEC harboring MAML2 rearrangement has a favorable prognosis. This study investigated the histologic and locational diversity of head and neck mucoepidermoid carcinoma, clinicopathologic characteristics, and associations with CRTC1/3::MAML2 fusion.

Prognostic Impact of Inflammation-Based Factors in Patients with Esophageal Squamous Cell Carcinoma Achieving Pathological Complete Response After Neoadjuvant Chemoradiotherapy Followed by Surgery.

Background: Patients achieving pathological complete response (pCR) post-neoadjuvant chemoradiotherapy (nCRT) and surgery for locally advanced esophageal squamous cell carcinoma (ESCC) have a favorable prognosis. However, recurrence occurs in approximately 20-30% of all patients, with few studies evaluating their prognostic factors. We identified these prognostic factors, including inflammation-based markers, in patients with ESCC showing pCR after nCRT and surgery.

Salivary Gland Neoplasms With a Unique Trabecular Histology and MAML2 Translocation : A Trabecular Variant of a Mucoepidermoid Carcinoma.

Mucoepidermoid carcinomas (MECs) are the most common salivary gland malignancy and have a diverse histology. Many histologic variants of MEC have now been confirmed with characteristic molecular alterations involving CRTC1::MAML2 or CRTC1::MAML3 translocations. We here report a series of 7 trabecular variants of MEC which showed a predominant trabecular or nested pattern with either focal glandular differentiation or clear cell change and keloid-like fibrosis in the background.

Assessment of thyroid cartilage ossification pattern in cancer patients: A suggestion of active ossification by tumor progression.

Background: Ossified cartilage is much more susceptible to cancer infiltration, but the reason remains unknown, and the relationship between the ossification pattern and cancer infiltration has not been studied.

Methods: The presence of thyroid cartilage ossification, cancer infiltration, ossification pattern (usual: direction from inferior to superior; unusual: other than the usual pattern), and distance between cancer and ossified cartilage were evaluated in laryngectomy specimens.

Results: There were 28 and 27 cases of usual and unusual patterns, respectively.

Clinical and Radiological Features of Diffuse Lacrimal Gland Enlargement: Comparisons among Various Etiologies in 91 Biopsy-Confirmed Patients.

Objective: To compare the clinical and radiological features of various etiologies of chronic diffuse lacrimal gland enlargement.

Materials And Methods: We retrospectively reviewed 91 consecutive patients who underwent surgical biopsy for chronic diffuse lacrimal gland enlargement and were diagnosed with non-specific dacryoadenitis (DA) (n = 42), immunoglobulin G4-related dacryoadenitis (IgG4-RD) (n = 33), and lymphoma (n = 16). Data on patient demographics, clinical presentation, and CT imaging findings (n = 73) and MRI (n = 43) were collected.

A sinonasal yolk sac tumor in an adult.

Yolk sac tumors (YSTs), which are also called endodermal sinus tumors, are malignant tumors of germ cell origin. These tumors usually occur in the gonads, but 20% of cases have been reported at extragonadal sites. The head and neck is a rarely affected region that accounts for just 1% of all malignant tumors of germ cell origin.

Retinal granular cell tumor: a case report.

Background: To report a rare case of granular cell tumor invading the retina.

Case Presentation: A 56-year-old female complained of blurred vision for 2 weeks in her left eye. An irregular-shaped retinal mass in the inferonasal and extending to the optic disc accompanied by dense exudation and extensive serous retinal detachment was observed.