The Community Health Workers and Mobile Health for Emerging Adults Transitioning Sickle Cell Disease Care (COMETS) Trial: Protocol for a Randomized Controlled Trial.

Background: Transitioning from pediatric to adult sickle cell disease (SCD) care is challenging for emerging adults (aged 17-25 years). This period is marked by a 7-fold increase in mortality rates and has the highest rates of hospitalizations, emergency room visits, and hospital readmissions compared with children living with SCD. These challenges are exacerbated by fragmented care coordination, difficulty navigating adult health care systems, and increased self-management responsibilities.

MODE: high-resolution digital dissociation with deep multimodal autoencoder.

In single cell biology, the complexity of tissues may hinder lineage cell mapping or tumor microenvi-ronment decomposition, requiring digital dissociation of bulk tissues. Many deconvolution methods focus on transcriptomic assay, not easily applicable to other omics due to ambiguous cell markers and reference-to-target difference. Here, we present MODE, a multimodal autoencoder pipeline linking multi-dimensional features to jointly predict personalized multi-omic profiles and cellular compositions, using pseudo-bulk data constructed by internal non-transcriptomic reference and external scRNA-seq data.

Uncapping energy transfer pathways in metal-organic frameworks through heterogeneous structures.

Metal-organic frameworks (MOFs) are porous, crystalline materials known for their structural versatility and high thermal stability, making them promising candidates for light-emitting diode applications. Distinct classes of MOFs, such as multivariate (MTV)-MOFs and MOF-on-MOFs, introduce heterogeneity by incorporating multiple ligands within a single unit cell (MTV-MOFs) or by stacking different MOFs on top of each other (MOF-on-MOF). Although these strategies improve their properties, the mechanisms of energy transfer between their heterogeneous components and their effects on optical properties, such as quantum yields, remain poorly understood.

Symmetric Intercalative Desalination of Brackish Water Without Ion-Exchange Membranes.

Ion-exchange membranes (IEMs) that separate cation-intercalation electrodes in symmetric Faradaic deionization (SFDI) increase the capital cost of desalination. We experimentally test SFDI cells that use nanofiltration (NF) membranes instead. Theory is first used to contrast the rate-dependent salt depletion in IEM-free SFDI with IEM-based SFDI.

Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease.

Front-line pharmaceutical treatment for treatment of acute graft-versus-host disease (aGVHD) is not uniformly effective and has toxic side effects. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with potent in vitro and in vivo immunosuppressive functions. Clinical translation of in vitro generated MDSCs has been limited by the need for high MDSC:T cell ratios, multiple infusions to reduce inflammation and a relatively low peripheral blood-derived MDSC (PB-MDSCs) yield.

Interspecies Haptic Sociality: An Observation of Grooming Between Two Mongoose Species.

Meerkats () and yellow mongooses () share many behavioural characteristics and are known to, on rare occasions, live in close association through displayed cooperative vigilance and shared burrow use. Here, we describe the first visual observation of tactile social behaviour through grooming between a meerkat and a yellow mongoose in the Rietvlei Nature Reserve, South Africa. We hypothesise that the close relationship between the two species in the reserve may be a response to a combination of phylogenetic ties, shared behavioural traits, and the population collapse of meerkats in the reserve that exposed a vacant social niche.

Quinoline-Based Organic Frameworks with Divergent Photocatalytic Properties for Hydrogen Production and Furfuryl Alcohol Oxidation.

The Sonogashira coupling reaction between 1,3,5-triethynylbenzene and two quinoline-based building units6-iodo-2-(4-iodophenyl)-4-phenylquinoline or 6-bromo-2-(5-bromopyridin-2-yl)-4-phenylquinolineresulted in the synthesis of conjugated materials designated as quinoline-based organic frameworks (QOFs), specifically and . These materials exhibited comparable structural and photophysical properties and demonstrated their utility in photocatalysis, including hydrogen evolution reactions (HER) and the selective oxidation of furfuryl alcohol to 5-hydroxy-2-(5)-furanone. Interestingly, outperformed in the photocatalytic oxidation of furfuryl alcohol via singlet oxygen (O), whereas exhibited superior efficiency in HER.

Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis.

MYC-driven group-3 medulloblastomas (MBs) are malignant pediatric brain cancers without cures. To define actionable metabolic dependencies, we identify upregulation of dihydrolipoyl transacetylase (DLAT), the E2-subunit of pyruvate dehydrogenase complex (PDC) in a subset of group-3 MB with poor prognosis. DLAT is induced by c-MYC and targeting DLAT lowers TCA cycle metabolism and glutathione synthesis.

Exercise-induced β-adrenergic receptor activation enhances effector lymphocyte mobilization in humans and suppresses lymphoma growth in mice through NK-cells.

Signaling through the β-adrenergic receptor (β2-AR) mobilizes immune cells during exercise and is implicated in tumor lymphocyte infiltration. We investigated mechanisms governing immune cell mobilization in humans and the role of adrenergic signaling in anti-cancer responses to a murine lymphoma. Human studies included double-blind, placebo-controlled, crossover trials with beta blocker drugs and a phosphodiesterase inhibitor during steady-state and graded exercise, and a synthetic β agonist (isoproterenol) infusion model.

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology.

Glial cells of the enteric nervous system (ENS) interact closely with the intestinal epithelium and secrete signals that influence epithelial cell proliferation and barrier formation in vitro. Whether these interactions are important in vivo, however, is unclear because previous studies reached conflicting conclusions (Prochera and Rao, 2023). To better define the roles of enteric glia in steady state regulation of the intestinal epithelium, we characterized the glia in closest proximity to epithelial cells and found that the majority express the gene Proteolipid protein 1 () in both mice and humans.

Optogenetic Mapping of Rhythmic Phase-Dependent Excitability in the Mouse Striatum.

The striatum is thought to switch flexibly between multiple converging inputs to support adaptive behavior. The "communication through coherence" (CTC) hypothesis is a potential mechanism to implement such a flexible switching. For CTC to work in the striatum, striatal excitability must show rhythmic fluctuations, such as those related to the phase of the striatal local field potential (LFP).

Corroborated evidence on change of metabolome after ischemic stroke due to large vessel occlusion.

Introduction: Metabolomic studies which search for acute ischemic stroke (AIS) biomarkers commonly have contradictory findings. Robust methodology is required to understand true metabolome changes after AIS.

Methods: To improve validity, we obtained corroborative evidence on change of serum metabolome after AIS by: (1) focusing on patients with large vessel occlusion (LVO), (2) combining cross-sectional and longitudinal study designs, and (3) performing analysis using different metabolome platforms: Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectrometry (LC-MS).

Behavioral microanalyses refine sign-tracking characterization and uncover different response dynamics during omission and extinction learning.

Sign-tracking, a conditioned response in which animals engage with reward-predictive cues, is a powerful behavioral tool for assessing Pavlovian motivation. In rodents, it is most frequently studied via automatic readouts, such as deflections of levers that act as reward cues. These readouts have been immensely helpful, but they may not be ideal for some tasks and paradigms.

Novel Metabolites as Potential Indicators of Recovery After Large Vessel Occlusion Stroke: A Pilot Study.

Serum metabolome changes after acute ischemic stroke (AIS), but the significance of this is poorly understood. We evaluated whether this change is associated with AIS outcomes in patients with large vessel occlusion (LVO). To improve validity, we combined cross-sectional and longitudinal designs and analyzed serum using Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectrometry (LC-MS).

Targeting cell-surface VISTA expression on allospecific naïve T cells promotes tolerance.

The success of allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be limited by graft-versus-host disease (GVHD). T-cell activation is a key factor in GVHD progression. Costimulatory signals can be counterbalanced by coinhibitory signals such as the checkpoint molecule VISTA (V-domain immunoglobulin-containing suppressor of T-cell activation)/programmed death-1 homolog that restrains activation and maintains donor T-cell quiescence.

Identifying Predictors of Extended Intensive Care Unit Stay Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: An Analysis of 101 ACS NSQIP Pediatric Participating Centers.

Background: While prolonged operative time and increased levels fused have been shown to increase the risk of prolonged intensive care unit (ICU) length-of-stay (LOS), studies are limited in guiding decision-making regarding the need for intensive care postoperatively. This is especially the case among the cohort of adolescent idiopathic scoliosis (AIS) patients undergoing posterior spinal fusion (PSF); associations between comorbidities and ICU LOS are not well-delineated.

Methods: AIS patients who underwent PSF from January 1st, 2016 to December 1st, 2016 at 101 participating centers were identified using the American College of Surgeons (ACS) National Surgical Quality Im-provement Project (NSQIP) Pediatric database.

Improving vascular access knowledge and assessment skill of hemodialysis staff.

Context: Vascular access malfunction and failure contribute to morbidity and hospitalization in hemodialysis populations. Although controversy still exists over the identification and appropriate management of access malfunction, recognition of sentinel signs during physical examination remains an efficient way to screen for access malfunction. Dialysis staff are on the front line of providing quality care to dialysis patients, often being the first ones who could detect early physical signs of access malfunction.

Impacts of the US CDC recommendation on human papillomavirus vaccine uptake, 2010-2015.

Objectives: As one type of vaccine policy, the effectiveness and spillover effects of the US CDC vaccine recommendations are inadequately evaluated. This study aims to fully evaluate its impacts on male adults, in addition to children, using better data.

Design: A before-after study design to examine the CDC's 2011 HPV vaccine recommendation for men aged 11-21.

Training young adults as community health workers specializing in pediatric to adult health care transition to support emerging adults with sickle cell disease.

Background: Transition to adulthood is a vulnerable time for emerging adults (16-25 years of age) with sickle cell disease (SCD), as there is a seven-fold increase in mortality rates during the transition period. Emerging adults with SCD also have the highest rates of hospitalizations, emergency room visits, and hospital readmissions compared to other age groups. Community health worker (CHW) programs have been developed to address outcomes such as patient activation which includes an individual's knowledge, skill, and confidence for managing one's health and healthcare, quality of life, and healthcare utilization for patients with chronic illnesses.

SEC-SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded-Over Conformations.

Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a "moonlighting" role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes. While robust methods exist to study entirely folded or unfolded proteins, structure-function studies of combined, mixed folded/disordered proteins remain challenging.

Boosting Photocatalytic Hydrogen Production by MOF-Derived Metal Oxide Heterojunctions with a 10.0 % Apparent Quantum Yield.

Photocatalytic hydrogen production offers an alternative pathway to establish a sustainable energy economy, utilizing the Earth's natural sunlight and water resources to address environmental concerns associated with fossil fuel combustion. While numerous photoactive materials exhibit high potential for generating hydrogen from water, the synergy achieved by combining two different materials with complementary properties in the form of heterojunctions can significantly enhance the rate of hydrogen production and quantum efficiency. Our study describes the design and generation of the metal-organic framework-derived (MOF) metal oxide heterojunction herein referred to as RTTA, composed of RuO/N,S-TiO.