Validation and standardization of the content of three di-caffeoylquinic acid in Korean Ligularia fischeri by region of origin.

Ligularia fischeri is a perennial plant in the Asteraceae family, native to Japan, China, Eastern Siberia, and Korea. It is generally known to be beneficial for anti-aging, bronchial diseases, anti-cancer, and constipation. In this study, Ligularia fischeri grown in five regions of Korea (Hahyang, Hongseong, Jeongseon, Nonsan, and Yangsan) were collected, and the absence of interfering substances was confirmed through HPLC analysis and chromatograms compared with standard substances.

Correction: The role of ambulatory blood pressure monitoring in enhancing medication adherence among patients with newly diagnosed hypertension: an analysis of the National Health Insurance cohort database.

[This corrects the article 6 in vol. 30, PMID: 38424656.].

Standardized Measurement of Muscle Strength and Physical Performance for Sarcopenia: An Expert-Based Delphi Consensus.

Background: Despite updated sarcopenia guidelines, inconsistent protocols still cause clinical confusion and may compromise diagnostic and outcome accuracy. This Delphi study aimed to establish expert consensus to support the standardization of muscle strength and physical performance assessments for sarcopenia.

Methods: A two-round modified Delphi study was conducted with 26 experts in geriatrics and sarcopenia.

Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial.

Importance: Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.

Objective: To determine whether amiloride is noninferior to spironolactone in reducing home-measured systolic blood pressure (SBP) in patients with resistant hypertension.

Multiple domain resilience components and frailty, postoperative complications, and one year quality of life deterioration after pancreatectomy in older patients.

The number of older adults is growing rapidly worldwide, and many surgical diseases are prevalent in this population. Resilience, the ability to adapt positively to adversity, remains a multisystemic process with no standardized objective measurement methods. The aim of this study was to identify the association between resilience components and frailty, postoperative complications, and quality of life changes after pancreatectomy in older patients.

Prediction of 5-Year Survival Rate After Hip Fracture Surgery Using a Comprehensive Geriatric Assessment-Based Frailty Score Model.

Background: Hip fractures (HFs) are major osteoporotic injuries associated with morbidity, loss of independence, increased mortality, and an increased socioeconomic burden. The total number of HFs is increasing owing to an aging population. While studies have focused on 30-day or 1-year mortality after HF surgery, studies reporting long-term mortality are lacking.

Chitosan-selenium nanoparticles suppress infectious spleen and kidney necrosis virus through immune modulation and viral replication inhibition in zebrafish (Danio rerio).

Infectious spleen and kidney necrosis virus (ISKNV) is one of the most challenging diseases causing substantial financial losses in global aquaculture. However, effective strategies for controlling ISKNV infections in ornamental fish are lacking. In this study, chitosan-selenium nanoparticles (CTS-SeNPs) were synthesized and evaluated as potential strategies for controlling ISKNV infection.

Pilot Study for Feasibility of Onco-Geriatric Intervention Model in Older Patients with Cancer in a Tertiary Academic Hospital.

Purpose: Older cancer patients face unique challenges due to age-related physiological changes, increasing their vulnerability to treatment-related toxicities. Geriatric assessment (GA) is a validated tool for optimizing care, yet there is no consensus on integrating geriatric interventions into oncology. This study evaluates the feasibility of a tailored onco-geriatric intervention model incorporating the KG-7 screening tool.

Development and Validation of a Machine Learning Method Using Vocal Biomarkers for Identifying Frailty in Community-Dwelling Older Adults: Cross-Sectional Study.

Background: The two most commonly used methods to identify frailty are the frailty phenotype and the frailty index. However, both methods have limitations in clinical application. In addition, methods for measuring frailty have not yet been standardized.

Role of Filter-Feeding Bivalves in the Bioaccumulation and Transmission of White Spot Syndrome Virus (WSSV) in Shrimp Aquaculture Systems.

White spot syndrome virus (WSSV) poses a major risk to shrimp aquaculture, and filter-feeding bivalves on shrimp farms may contribute to its persistence and transmission. This study investigated the bioaccumulation and vector potential of WSSV in Pacific oysters (), blue mussels (), and manila clams () cohabiting with WSSV-infected shrimp. Sixty individuals of each species (average shell lengths: 11.

Rapid Visual Detection of Red Sea Bream Iridovirus Using a Novel Cross-Priming Amplification-Based Lateral Flow Assay.

Red sea bream iridovirus (RSIV) occurs mainly at high water temperatures and infects more than 30 different species of fish. In Asia, infected fish cause mass mortality every year. Molecular diagnostics is a technology that efficiently detects and identifies a wide range of fish pathogens through rapid and sensitive analysis of their genetic material.

Development and validation of reverse-transcription cross-priming amplification-based lateral flow assay for the detection of infectious hematopoietic necrosis virus.

Infectious hematopoietic necrosis virus (IHNV) severely and lethally infects salmonid fish, including Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) worldwide. Rapid and accurate viral detection is crucial for preventing pathogen spread and minimizing damage. Although several IHNV detection assays have been developed, their analytical and diagnostic performances have not been evaluated and field usability assessments have not been completely validated.

Evaluation of Formalin-Inactivated Vaccine Efficacy against Red Seabream Iridovirus (RSIV) in Laboratory and Field Conditions.

Red seabream iridovirus (RSIV) is a major cause of marine fish mortality in Korea, with no effective vaccine available since its first occurrence in the 1990s. This study evaluated the efficacy of a formalin-killed vaccine against RSIV in rock bream under laboratory and field conditions. For the field trial, a total of 103,200 rock bream from two commercial marine cage-cultured farms in Southern Korea were vaccinated.

Information technology-supported integrated health service for older adults in long-term care settings.

Background: To examine the effectiveness and safety of a data sharing and comprehensive management platform for institutionalized older patients.

Methods: We applied information technology-supported integrated health service platform to patients who live at long-term care hospitals (LTCHs) and nursing homes (NHs) with cluster randomized controlled study. We enrolled 555 patients aged 65 or older (461 from 7 LTCHs, 94 from 5 NHs).

Association Between Orthostatic Hypertension and Frailty Among Older Patients With Hypertension.

Background: Frailty frequently coexists with hypertension in older patients. We aimed to evaluate the association between frailty and positional change in blood pressure, especially orthostatic hypertension.

Methods: Participants were recruited from 12 University hospitals in South Korea.

Characteristics According to Frailty Status Among Older Korean Patients With Hypertension.

Background: As the prevalence of hypertension increases with age and the proportion of the older population is also on the rise, research on the characteristics of older hypertensive patients and the importance of frailty is necessary. This study aimed to identify clinical characteristics of older hypertension in Korea and to investigate these characteristics based on frailty status.

Methods: The HOW to Optimize eLDerly systolic BP (HOWOLD-BP) is a prospective, multicenter, open-label, randomized clinical trial that aims to compare intensive (target systolic blood pressure [SBP] ≤ 130 mmHg) with standard (target SBP ≤ 140 mmHg) treatment to reduce cardiovascular events in older hypertensive Korean patients aged ≥ 65 years.

The role of ambulatory blood pressure monitoring in enhancing medication adherence among patients with newly diagnosed hypertension: an analysis of the National Health Insurance cohort database.

Background: Improving adherence to antihypertensive medication (AHM) is a key challenge in hypertension management. This study aimed to assess the impact of ambulatory blood pressure monitoring (ABPM) on AHM adherence.

Methods: We utilized the Korean National Health Insurance Service database.

Effects on viral suppression and the early-immune expression of ribavirin against spring viremia of carp virus in vitro.

Spring viremia of carp virus (SVCV) is a globally distributed virus that causes severe clinical symptoms and high mortality in fish belonging to the families Cyprinidae and Siluridae. To protect the host against viral infection, understanding the relatedness between viral susceptibility and antiviral mechanisms must be crucial. Thus, we evaluated the viral suppression efficacy of ribavirin by measuring the transcription levels of viral and immune genes in vitro.

Development of a claims-based risk-scoring model to predict emergency department visits in older patients receiving anti-neoplastic therapy.

This study developed and validated a risk-scoring model, with a particular emphasis on medication-related factors, to predict emergency department (ED) visits among older Korean adults (aged 65 and older) undergoing anti-neoplastic therapy. Utilizing national claims data, we constructed two cohorts: the development cohort (2016-2018) with 34,642 patients and validation cohort (2019) with 10,902 patients. The model included a comprehensive set of predictors: demographics, cancer type, comorbid conditions, ED visit history, and medication use variables.

Digital Health Technology Use Among Older Adults: Exploring the Impact of Frailty on Utilization, Purpose, and Satisfaction in Korea.

Background: The importance of digital technology is increasing among older adults. In this study, the digital health technology utilization status, purpose, and satisfaction of older adults were investigated according to frailty.

Methods: A face-to-face survey was conducted among adults aged 65 years or older.

Development and validation of a machine learning-based fall-related injury risk prediction model using nationwide claims database in Korean community-dwelling older population.

Background: Falls impact over 25% of older adults annually, making fall prevention a critical public health focus. We aimed to develop and validate a machine learning-based prediction model for serious fall-related injuries (FRIs) among community-dwelling older adults, incorporating various medication factors.

Methods: Utilizing annual national patient sample data, we segmented outpatient older adults without FRIs in the preceding three months into development and validation cohorts based on data from 2018 and 2019, respectively.

Protective Effects of Protein-Rich Extract Against Cisplatin-Induced Nephrotoxicity in HEK293 Cells and a Mouse Model.

Cisplatin, a potent and prominent chemotherapeutic drug, has considerable side effects, including nephrotoxicity, which limits its therapeutic application and efficacy. Therefore, the development of agents that protect normal cells while preserving cisplatin's chemotherapeutic properties is of utmost importance. This study aimed to explore the protective effects of protein-rich extract (BBPE) against cisplatin-induced nephrotoxicity in a cisplatin-treated mouse model and human embryonic kidney (HEK293) cells.

Identification of Various InDel-II Variants of the White Spot Syndrome Virus Isolated from Frozen Shrimp and Bivalves Obtained in the Korean Commercial Market.

White spot syndrome virus (WSSV) poses a significant threat to the global shrimp industry. We investigated the presence of WSSV in frozen shrimp ( = 86) and shellfish ( = 185) from the Korean market (2010-2018). The detection rate of first-step polymerase chain reaction (PCR) in domestic shrimp was 36.