Emerging Roles of Ferroptosis in Skin Pathophysiology.

Programmed cell death (PCD) is a hallmark of tissue homeostasis and numerous human diseases. Ferroptosis, a more recently discovered type of PCD, is uniquely dependent on enzymatically driven accumulation of specific hydroperoxy-phospholipid species and iron-dependent reduction-oxidation (redox) dysregulation. Emerging evidence suggests that ferroptosis plays a critical role in the pathogeneses of several dermatologic disorders, including infections, malignancies, and chronic inflammatory and autoimmune diseases.

Increased platelet activation and thrombo-inflammation in early and late-onset preeclampsia.

Background: Preeclampsia is a vascular complication of pregnancy with limited therapeutic options. It is associated with hypertension and an increase in angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor. Based on its onset, preclampsia can be categorized into early-onset (E-PE) or late-onset (L-PE) preeclampsia.

15-Lipoxygenase-dependent radiomitigation by NO-Donors suppresses ferroptosis in intestinal Epithelium: Multiomics MS imaging and LC-MS evidence.

Threats of irradiation (IR) exposure increase the need for radiomitigators. An important contributor to radiation injury is ferroptosis, triggered by the disbalanced redox metabolism. We showed that 15-lipoxygenase (15-LOX) catalyzed peroxidation of arachidonoyl-phosphatidyl-ethanolamine is an essential ferroptotic response of ileum to total body IR (TBI).

Role of ultrasound-guided brachiocephalic venous cannulation for difficult venous cannulation in pediatric patients: A narrative review.

Difficult venous access is characterized by non-visible and non-palpable veins; a highly experienced operator is required with the use of technological aids to insert a vascular device. Patients with difficult venous cannulation undergo multiple, painful attempts to gain peripheral venous access. Compared to adults, inserting a central venous cannulation (CVC) is thought to be a more difficult procedure in children, particularly in neonates and young infants.

Corrigendum to "Advances in detection technology for authentication of vegetable oils: A comprehensive review" [Heliyon Volume 10, Issue 15, August 15, 2024, Article e34759].

[This corrects the article DOI: 10.1016/j.heliyon.

Multidisciplinary assessment of the impact of assisted reproductive techniques on pregnancy and long-term outcomes of mother and child: Foundation of the LE-REP (Leipzig Reproductive Health) Center.

About 8-10 % of all people of reproductive age are unable to conceive children. In recent years, an increased number of consultations for fertility treatments has been observed with a continuing positive trend. It is known that infertility itself and assisted reproductive technologies (ARTs) are frequently associated with recurrent miscarriages, pregnancy complications or psychosocial problems.

Analgesic efficacy of ultrasound-guided retrolaminar block in truncal surgeries: A narrative review.

Postoperative pain management in patients undergoing thoracoabdominal surgery always remains challenging for the anesthesiologist. As a method of pain management, multimodal analgesia is commonly used. In recent years, interfascial plane blocks like erector spine plane block (ESPB), retrolaminar block (RLB), transverse thoracic plane block, and pectointercostal plane block have been increasingly utilized as important components of acute postoperative pain management in truncal surgeries.

Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease.

Dysregulations of epithelial-immune interactions frequently culminate in chronic inflammatory diseases of the skin, lungs, kidneys, and gastrointestinal tract. Yet, the intraepithelial processes that initiate and perpetuate inflammation in these organs are poorly understood. Here, by utilizing redox lipidomics we identified ferroptosis-associated peroxidation of polyunsaturated phosphatidylethanolamines in the epithelia of patients with asthma, cystic fibrosis, psoriasis, and renal failure.

Comparative evaluation of nebulised dexmedetomidine vs fentanyl for the treatment of post-dural puncture headache (PDPH) in parturients after caesarean section under spinal anaesthesia: A randomised controlled study.

Background And Aims: The incidence of post-dural puncture headache (PDPH) following spinal anaesthesia in the obstetric population is around 0.5%-2%. Hydration, bed rest, caffeine, paracetamol, non-steroid anti-inflammatory drugs, epidural blood patches, etc.