[Ga] labelled Exendin for radioguided surgery of intrapancreatic insulin producing lesions in patients with congenital hyperinsulinism.

Background: Congenital hyperinsulinism (CHI) is a life threatening disease. Localization of affected intrapancreatic beta cells responsible for focal forms during surgery can be challenging. In this study we investigated a new radioguided surgical (RGS) approach using [Ga]Exendin to facilitate intraoperative focus detection.

Comparison of Fetal Middle Cerebral Artery and Umbilical Artery Doppler Indices as Predictors of Perinatal Outcomes in Fetal Growth-Restricted Pregnancies.

Introduction: Fetal growth restriction (FGR) is considered a major contributor to perinatal morbidity and mortality. Umbilical artery (UA) Doppler has been widely utilized for assessing FGR. Recent evidence suggests that Doppler assessment of the middle cerebral artery (MCA) may also serve as a valuable tool in predicting perinatal outcomes.

Human Papillomavirus Vaccine Hesitancy and Barriers in Achieving 100% Vaccine Coverage: A Web-based Cross-sectional Study.

Introduction: The human papillomavirus (HPV) vaccine is one of the most effective primary measures to prevent HPV-related infections and deadly cancers. Despite the availability of the HPV vaccine in the market for almost 17 years, it still remains underutilized. This study is planned with the objective to find out the reasons for vaccine hesitancy (VH) among the Indian population.

Hepatitis E-Induced Worsening of Antiphospholipid Syndrome With Extensive Thrombosis: A Case Report.

Antiphospholipid syndrome (APS) is an autoimmune disease that can result in a wide range of thromboembolic events. We report on a young male who presented with abdominal pain and was found to have extensive splanchnic vein thrombosis (SVT). Incidentally, he tested positive for the following: hepatitis E virus (HEV) immunoglobulin M (IgM) antibody and antiphospholipid antibodies (aPL), including anticardiolipin and anti-beta2-glycoprotein antibodies.

Prediction of Preeclampsia Using Machine Learning: A Systematic Review.

Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality. Early prediction is the need of the hour so that interventions like aspirin prophylaxis can be started. Nowadays, machine learning (ML) is increasingly being used to predict the disease and its prognosis.

Ruptured Hepatocellular Carcinoma: A Case Report.

Hepatocellular carcinoma (HCC) is one of the most common primary liver tumors in the world. In the United States, it is very uncommon for the liver mass to spontaneously rupture, especially if it has already been treated with embolization. Prompt diagnosis and treatment are necessary to improve the overall prognosis.

Catastrophic Antiphospholipid Syndrome: A Life-Threatening Condition.

Antiphospholipid syndrome (APS) is characterized by thrombosis in any organ or tissue, accompanied by the presence of antiphospholipid antibodies. Although rare, APS can progress to catastrophic APS (CAPS), a life-threatening complication involving the development of multi-organ thromboses. The mortality rate is high.

Pleural Metastatic Melanoma With Recurrent Malignant Pleural Effusions.

Pleural metastatic melanoma is rare, and associated malignant pleural effusions are even rarer. We present a case of pleural metastatic melanoma with recurrent malignant pleural effusions. The initial diagnosis showed no metastatic disease, and the patient underwent resection and received a year of immunotherapy for localized disease.

Sirenomelia in Twin Pregnancy: A Case Report.

Sirenomelia is a rare congenital disorder that was once thought to be a severe case of caudal regression but is now thought to be entirely separate. It is often referred to as the "mermaid syndrome" because it causes the lower limbs to atrophy to varying degrees, giving the impression of a mermaid's tail or fin. The syndrome is often viewed as fatal due to the accompanying visceral deformities.

Impact of the PI3K-alpha inhibitor alpelisib on everolimus resistance and somatostatin receptor expression in an orthotopic pancreatic NEC xenograft mouse model.

The mechanistic target of rapamycin complex 1 (mTORC1) inhibitor everolimus is one of the few approved therapies for locally advanced and metastatic neuroendocrine tumours (NETs). However, after initial disease stabilisation, most patients develop resistance within 1 year. Our aim was to overcome resistance to everolimus by additional treatment with the PI3K-alpha inhibitor alpelisib in an everolimus-resistant orthotopic pancreatic neuroendocrine carcinoma xenograft mouse model.

Immune Thrombocytopenia following COVID-19 Vaccine.

Several vaccines have been developed and are being administered against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Common side effects include fever, chills, headache, myalgia, and soreness at the injection site. However, some rare adverse effects have also been reported.

Effect of Peptide Dose on Radiation Dosimetry for Peptide Receptor Radionuclide Therapy with Lu-DOTATOC: A Pilot Study.

Background: Optimal peptide concentration in treatment with Lu-DOTATOC/DOTATATE is a matter of debate. Most of the studies with peptide receptor radionuclide therapy mention peptide dose ranging between 100 and 250 μg. The aim of this is to identify possible differences in radiation-absorbed doses (D/Gy) to tumor and kidney as a function of the peptide mass dose in order to identify the most suitable peptide dose for treatment.

The Development of Cognate Awareness in Child Second/Third Language Learners of French in French Immersion: The Effects of Orthographic Overlap and Cognate Status.

Purpose Our 1-year longitudinal study tracked the development of cognate awareness among second (L2) and third language (L3) learners of French in French immersion in Grades 1 and 2 to explore the impact of orthographic overlap and cognate status (true vs. false) on children's ability to recognize cognate relationships. We also assessed the impact of French L2/L3 status on performance.

Long-term outcomes following Fetal Alcohol Spectrum Disorder (FASD) diagnosis in adulthood.

Background: Early diagnosis of Fetal Alcohol Spectrum Disorder (FASD) is known to improve outcomes in children. It is less clear if diagnosis in adulthood also conveys benefits. This study investigated long-term outcomes for individuals diagnosed with FASD after 18 years of age.

Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications.

Annexin A5 (anxA5) is a marker for apoptosis, but has also therapeutic potential in cardiovascular diseases, cancer, and, due to apoptotic mimicry, against dangerous viruses, which is limited by the short blood circulation. An 864-amino-acid XTEN polypeptide was fused to anxA5. XTEN864-anxA5 was expressed in Escherichia coli and purified using XTEN as tag.

Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism.

Surgery with curative intent can be offered to congenital hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled exendin-4 specifically binds the glucagonlike peptide 1 receptor on pancreatic β-cells. In this study, we compared the performance of F-DOPA PET/CT, the current standard imaging method for CHI, and PET/CT with the new tracer Ga-NODAGA-exendin-4 in the preoperative detection of focal CHI.

SPECT/CT Imaging, Biodistribution and Radiation Dosimetry of a Lu-DOTA-Integrin αvβ6 Cystine Knot Peptide in a Pancreatic Cancer Xenograft Model.

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant neoplasms, as many cases go undetected until they reach an advanced stage. Integrin αvβ6 is a cell surface receptor overexpressed in PDAC. Consequently, it may serve as a target for the development of probes for imaging diagnosis and radioligand therapy.

In Comparison to PSA, Interim Ga-68-PSMA PET/CT Response Evaluation Based on Modified RECIST 1.1 After 2 Cycle Is Better Predictor of Overall Survival of Prostate Cancer Patients Treated With Lu-PSMA.

Background: Prostate-specific membrane antigen (PSMA) targeting radioligands have transformed treatment of prostate cancer. Radioligand therapy (RLT) with Lu-PSMA in metastasized castration resistant prostate cancer (mCRPC) achieves objective response and disease stabilization in roughly two third of patients, whereas one third of patients progress. This study was performed to assess the role of interim PSMA PET/CT after the 2 cycle of RLT for early prediction of overall survival in patients undergoing RLT with Lu-PSMA.

Radixin modulates the function of outer hair cell stereocilia.

The stereocilia of the inner ear sensory cells contain the actin-binding protein radixin, encoded by RDX. Radixin is important for hearing but remains functionally obscure. To determine how radixin influences hearing sensitivity, we used a custom rapid imaging technique to visualize stereocilia motion while measuring electrical potential amplitudes during acoustic stimulation.

A Cyanine-Bridged Somatostatin Hybrid Probe for Multimodal SSTR2 Imaging in Vitro and in Vivo: Synthesis and Evaluation.

Multimodal imaging probes have attracted the interest of ongoing research, for example, for the surgical removal of tumors. Modular synthesis approaches allow the construction of hybrid probes consisting of a radiotracer, a fluorophore and a targeting unit. We present the synthesis of a new asymmetric bifunctional cyanine dye that can be used as a structural and functional linker for the construction of such hybrid probes.

Multimodal Imaging of 2-Cycle PRRT with Lu-DOTA-JR11 and Lu-DOTATOC in an Orthotopic Neuroendocrine Xenograft Tumor Mouse Model.

Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin receptor (SSTR) analogs is a common approach in advanced neuroendocrine neoplasms. Recently, SSTR antagonists have shown promising results for imaging and therapy due to a higher number of binding sites than in commonly used agonists. We evaluated PRRT with SSTR agonist Lu-DOTATOC and antagonist Lu-DOTA-JR11 longitudinally in an orthotopic murine pancreatic neuroendocrine neoplasm model expressing human SSTR2.

Relationship of Renal Function in Mice to Strain, Sex and 177Lutetium-Somatostatin Receptor Ligand Treatment.

Aim:  Aim of the study was to establish parameters for Tc-MAG3 SPECT renal uptake kinetics in healthy SCID mice as a function of mouse strain and sex and to evaluate the feasibility of this method for detecting Lu-somatostatin receptor ligand (Lu-SRL) treatment effects on kidney function.

Materials And Methods:  Dynamic semi-stationary SPECT acquisitions (68 frames, total duration 35 min) was started prior to i. v.