Publications by authors named "Kunal Kumar Singh"
Article Synopsis
- Low molecular weight heparins (LMWH) are used in pregnancy to prevent or treat thromboembolic events and may have protective effects against preeclampsia, although their use in this context is debated.
- Recent research shows that LMWH can reduce pregnancy loss and inflammation-related activation of the NLRP3 inflammasome in trophoblasts, which are crucial for a healthy pregnancy.
- The mechanism involves LMWH activating the heparin-binding epidermal growth factor (HBEGF) pathway, which prevents inflammasome activation and could provide a rationale for using LMWH in managing preeclampsia.
Article Synopsis
- Diabetes significantly increases the risk of heart failure (HF), particularly affecting those with type-2 diabetes mellitus (T2DM), leading to worse health outcomes once HF develops.
- The study aimed to identify clinical and laboratory factors influencing BNP and ejection fraction (EF) to predict early signs of HF in T2DM patients who don't show obvious HF symptoms.
- Conducted over two months with 308 participants, the study utilized statistical testing to analyze the relationship between NT-proBNP, EF, and other factors, aiming to provide insights for preventing HF in high-risk diabetic patients.
Procoagulant extracellular vesicles (EV) and platelet activation have been associated with gestational vascular complications. EV-induced platelet-mediated placental inflammasome activation has been shown to cause preeclampsia-like symptoms in mice. However, the effect of EV-mediated placental thrombo-inflammation on trophoblast differentiation remains unknown.
View Article and Find Full Text PDFExcess platelet activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, interleukin 1β (IL-1β) activation, preeclampsia (PE), and partial embryonic lethality. Embryonic thrombomodulin (TM) deficiency, which causes embryonic lethality hallmarked by impaired trophoblast proliferation, has been linked with maternal platelet activation. We hypothesized that placental TM loss, platelet activation, and embryonic lethality are mechanistically linked to trophoblast inflammasome activation.
View Article and Find Full Text PDFEye disorders and resulting visual loss are major public health problems affecting millions of people worldwide. In this context, the sclera is an opaque, thick outer coat covering more than 80% of the eye, and essential in maintaining the shape of the eye and protecting the intraocular contents against infection and the external environment. Despite efforts undertaken to decipher the scleral proteome, the functional and structural picture of the sclera still remain elusive.
View Article and Find Full Text PDFConsumption of fish containing ciguatera toxins or ciguatoxins (CTXs) causes ciguatera fish poisoning (CFP). In some patients, CFP recurrence occurs even years after exposure related to CTXs accumulation. Pacific CTX-1 (P-CTX-1) is one of the most potent natural substances known that causes predominantly neurological symptoms in patients; however, the underlying pathogenies of CFP remain unknown.
View Article and Find Full Text PDF