Dynamic Tenodesis Technique for Ulnar Drift With Extensor Tendon Subluxation due to Rheumatoid Arthritis.

Purpose: We investigated the outcomes of an original functional reconstruction procedure for ulnar drift (UD) with extensor tendon subluxation due to rheumatoid arthritis.

Methods: From 2018 to 2022, reconstruction was performed in 10 patients (31 fingers), with UD due to rheumatoid arthritis and a minimum of 2-year follow-up. The mean age was 57 years, and the mean follow-up period was 4.

A Rare Presentation of Pneumonic-Type Adenocarcinoma Hidden behind Empyema.

Pneumonic-type adenocarcinoma (P-ADC) can closely mimic pneumonia. We report a P-ADC initially diagnosed as pneumonia which developed into a pulmonary abscess and empyema. A 50-year-old Japanese male diagnosed with pneumonia, pulmonary abscess, and empyema was administered antibiotics and a chest tube for drainage, which improved his symptoms and blood test results.

Hypoxic Conditions Promote Cartilage Repair in a Rat Knee Osteochondral Defect Model via Hypoxia-Inducible Factor-1α.

Bone marrow stimulation is a treatment for articular cartilage injuries that promotes cartilage repair by inducing the migration and accumulation of mesenchymal stem cells (MSCs), but often results in fibrocartilage with limited durability. This study aimed to investigate the effect of hypoxic conditions on cartilage repair using a rat osteochondral defect model. Osteochondral defects (1.

PRP and Cotton-Like β-TCP/PLGA Fibers Enhance Bone Repair in Osteoporotic Vertebral Defects via Macrophage Modulation in Rats.

This study assessed the effectiveness of a combination of platelet-rich plasma (PRP) and β-tricalcium phosphate/polylactic-co-glycolic acid (β-TCP/PLGA) fibers in the treatment of osteoporotic vertebral defects in rats. Seventy-two female Sprague-Dawley rats subjected to ovariectomy to induce osteoporosis were divided into three groups to receive different treatments for critical bone defects created in the lumbar vertebrae. The PRP group received β-TCP/PLGA fibers infused with PRP, the control group received no material, and the other group received the same fibers infused with phosphate-buffered saline (PBS).

PRP and Cotton-Like β-TCP/PLGA Fibers Enhance Bone Repair in Osteoporotic Vertebral Defects via Macrophage Modulation in Rats.

This study assessed the effectiveness of a combination of platelet-rich plasma (PRP) and β-tricalcium phosphate/polylactic-co-glycolic acid (β-TCP/PLGA) fibers in the treatment of osteoporotic vertebral defects in rats. Seventy-two female Sprague-Dawley rats subjected to ovariectomy to induce osteoporosis were divided into three groups to receive different treatments for critical bone defects created in the lumbar vertebrae. The PRP group received β-TCP/PLGA fibers infused with PRP, the control group received no material, and the other group received the same fibers infused with phosphate-buffered saline (PBS).

High dynamic range capillary electrophoresis method for sensitive detection of low-frequency driver mutations.

Cancer genomics aims to personalize treatments by identifying genetic abnormalities in cancer cells. However, current analytical techniques face limitations in simplicity and cost-effectiveness. To address these issues, we developed an enhanced capillary gel electrophoresis (CE) sequencer using a fluorescence-acquisition technique called "HiDy" (High Dynamic range) (HiDy-CE).

Clinical outcomes of primary repair for large and massive rotator cuff tears using an all-arthroscopic rotator cuff muscle advancement technique.

Background: The retear rate after repair of large and massive rotator cuff tears remains high. In this study, we report on the clinical outcomes of an all-arthroscopic rotator cuff muscle advancement technique, which retained the fascial continuity between the origin of the rhomboid and rotator cuff muscles at postoperative in patients with large or massive rotator cuff tears.

Methods: The all-arthroscopic technique for muscle advancement in the repair of large or massive rotator cuff tears is based on the Debeyre-Patte procedure and included dissection of the medial insertions of the supraspinatus (SSP) and infraspinatus (ISP) muscles from the superior, medial, and inferior borders of the scapula, maintaining the fascial continuity with the rhomboid muscle at the medial border of the scapula.

Alzheimer's Disease With Cardiac Transthyretin Amyloidosis: A Clinicopathological Study of Autopsy Cases.

The relationship between Alzheimer's disease and cardiac transthyretin amyloidosis (ATTR) has been reported epidemiologically. However, the details of its clinicopathological characteristics are unclear. To clarify the pathogenesis of Alzheimer's disease combined with cardiac ATTR, 50 autopsy cases of Alzheimer's disease with cardiac hypertrophy were examined.

Mild hyperbaric hyperoxia improves aerobic capacity and suppresses cardiopulmonary stress during the maximal cycle-ergometer test.

Aerobic exercise is more recommended than anaerobic exercise for individuals with cardiopulmonary dysfunction to avoid cardiopulmonary stress. However, their oxygen-carrying capacity is already reduced, making it difficult to exercise enough. Therefore, we aimed to investigate whether mild hyperbaric hyperoxia enhances aerobic capacity and decreases cardiopulmonary stress during exercise with a particular focus on the ventilatory threshold (VT).

Machine learning-driven generation and screening of potential ionic liquids for cellulose dissolution.

Cellulose, a highly versatile material, faces challenges in processing due to its limited solubility in common solvents. Ionic liquids have been found to possess high solvating capacities for cellulose. However, the experimental development of ionic liquids with optimal cellulose solubilities remains a time-consuming trial-and-error process.

Belt Electrode-Skeletal Muscle Electrical Stimulation Prevents Muscle Atrophy in the Soleus of Collagen-Induced Arthritis Rats.

We investigated the effects of belt electrode-skeletal muscle electrical stimulation (B-SES) on muscle atrophy in collagen-induced arthritis (CIA) rats. Twenty-eight 8-week-old male Dark Agouti rats were immunized with type II collagen and Freund's incomplete adjuvant (day 0). From days 14 to 28, 18 rats received B-SES (50 Hz) four times only on the right hindlimb (STIM), while the contralateral left hindlimb remained unstimulated.

Long-Term Outcomes and Prognostic Factors of Medial Open Wedge High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis or Osteonecrosis.

Medial open wedge high tibial osteotomy (MOWHTO) has led to favorable clinical results since the introduction of locking plates. Surgical indications, techniques, and postoperative alignment are crucial for achieving favorable clinical outcomes. This study analyzed the clinical outcomes of patients after >5 years of post-MOWHTO follow-up to identify the influential factors.

Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model.

Hypoxia-inducible factor-1α plays an important role in the homeostasis of articular cartilage in hypoxic environments. Therefore, modulation of hypoxia-inducible factor-1α by regulating the oxygen environment could be a useful treatment for osteoarthritis. This study aimed to assess the chondroprotective effects of intermittent hypoxia on cultured chondrocytes and an animal model of osteoarthritis.

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors.

Pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursor lesions. Detecting these precursors and monitoring their progression are crucial for early PDAC diagnosis. Digital PCR (dPCR) is a highly sensitive nucleic acid quantification technique and offers a cost-effective option for patient follow-up.

Recommendations for use of extracorporeal shockwave therapy in sports medicine: an international modified Delphi study.

Objectives: While extracorporeal shockwave therapy (ESWT) may be an efficacious adjunctive treatment option for musculoskeletal injuries, current research is limited by significant heterogeneity within treatment protocols. This study aims to establish international expert consensus recommendations on ESWT terminology, parameters, procedural considerations, contraindications and side effects in the application of ESWT to sports injuries.

Methods: A systematic literature search was performed on the use of ESWT for musculoskeletal and sports medicine injuries to identify potential panellists, followed by the development of a steering committee-led questionnaire.

Rapid Biodegradation Assessment of Biomass Plastics Using Closed Recirculating Aquaculture Systems: A Novel Approach for Environmental Sustainability.

The increasing plastic production causes serious problems in the marine environment, and the main source of plastic waste comes from the fishing and aquaculture industries. Although there have been various efforts to develop aquaculture equipment with marine biodegradable plastics, an urgent need is to develop an assay to evaluate their biodegradation in aquaculture environments. This study focused on evaluating the biodegradation of biomass plastic in recirculating aquaculture systems (RAS) that mimic freshwater, brackish water, and saltwater aquacultures.

A low-viscous and flowable zwitterionic liquid.

Zwitterionic liquids have attracted significant attention in various fields due to their low-toxicity and the ability to tune their functional properties. However, despite being liquid in thermo-dynamic definition, zwitterionic liquids are not commonly recognized as "liquids" by the general public because of their extremely high viscosity, comparable to that of peanut butter, which prevents stirring even with a strong magnetic stirrer. In this study, we developed a flowable and stirrable zwitterionic liquid, OEimOEC.

Prognostic indicators of postoperative objective improvement in carpal tunnel syndrome: A retrospective study.

Background: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy affecting the upper limb, with surgical intervention as the primary treatment. This study aims to identify predictive factors influencing postoperative motor and sensory recovery following carpal tunnel release (CTR).

Methods: A retrospective analysis was conducted on 95 patients (117 hands), with objective outcomes measured by tip pinch strength and two-point discrimination (2PD) six months postoperatively.

Tumor Necrosis Factor-Alpha (TNF-α) and Interleukin-6 (IL-6) Cytokines in the Injured Meniscus of Patients With Knee Subchondral Insufficiency Fractures: A Potential Association With Preoperative Pain.

Background The development of subchondral insufficiency fracture (SIF) of the knee following a medial meniscal posterior root tear (MMPRT) results in pain and limitations in daily activities. Pain in patients with SIF is associated with local chronic inflammation in the knee joint, involving the production of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and nerve growth factor (NGF). This study aimed to quantify the levels of proinflammatory cytokines (TNF-α, IL-6, NGF) in the injured medial meniscus (IMM) tissue of patients with knee SIF and examine their potential association with preoperative pain and functional scores.

Exploring Volatiles and Biological Effects of and Incense.

The resin of and the resin and bark of play versatile roles in traditional Sudanese culture, including use in inhalation therapy, liquid remedies, and as chewing gum. Thus, this study aimed to analyze the volatile compounds in these materials using various extraction methods and assess their biological activities. Extraction methods included MonoTrap solid-phase microextraction, smoke solvent trapping, and acetone immersion.

Impact of COVID-19 on orthopedic trauma patients from 2021 to 2022 when restrictions were lifted, compared with the pre-pandemic period.

Background: The coronavirus disease 2019 (COVID-19) pandemic restricted the activities of the general population and affected health systems, which adapted medical resources to manage COVID-19 treatment. During the initial lockdown, trauma volumes decreased. However, it is unknown whether trauma volumes changed from 2021 to 2022, the late pandemic period when COVID-19 vaccination began and restrictions were gradually lifted.

Fully bio-based cellulose ester synthesis from natural aldehydes aerobic oxidation.

This study presents a novel synthetic method to synthesize fully bio-based cellulose esters from natural aldehydes in a multi-functional ionic liquid (as a solvent for cellulose and as an esterification and oxidation catalyst) in atmospheric oxygen. The aerobic oxidative esterification of cellulose with high atom economy proceeded under metal-free conditions without any additional catalysts or activators.

Dual-Functionalized Zwitterionic Polymers for Cell Cryopreservation.

Cryopreservation is an essential technique for the long-term preservation of cells. Some cells are challenging to cryopreserve, and novel cryoprotective agents are required. We previously reported a zwitterionic polymer (poly(ZI)) as a cryoprotectant that forms a polymer matrix surrounding the cells and partially prevents intracellular ice formation.