Can foliar application of soluble monoammonium phosphate effectively alleviate herbicide-induced oxidative stress in key crops?

Phosphorus (P) and nitrogen (N) directly impact final crop productivity by playing essential roles in photosynthesis, ATP formation, carbon assimilation, cell division, and transport. Compared with nutrient application to soil, the nutrients are applied directly to leaves provides a faster response because the nutrients enter plant metabolism more quickly. Foliar fertilization with nutritional supplements can intend to increase crop yields, and little is known about its ability to reduce oxidative stress.

Toxicity assessment of airborne ultrafine particles: Role of transport emissions.

Airborne quasi-ultrafine particle samples were collected from different outdoor sites in Barcelona (NE Spain, 35 samples) and the Valencia subway (about 400 km south of Barcelona, 3 samples). Locations and schedules were designed to cover cold and warm seasons and to represent the impact of different types of transport (cars, trains, ships, and planes). Extracts from PTFE filters (methanol:dichloromethane 1:2) were used to test toxic effects in human cell lines (Induction of reactive oxygen species, inflammatory response) and in zebrafish embryos (expression of xenobiotic response-related genes, cyp1a1, gsa1 and hao1).

Toxicity of airborne nanoparticles: Facts and challenges.

Air pollution is one of the most severe environmental healthhazards, and airborne nanoparticles (diameter <100 nm) are considered particularly hazardous to human health. They are produced by various sources such as internal combustion engines, wood and biomass burning, and fuel and natural gas combustion, and their origin, among other parameters, determines their intrinsic toxicity for reasons that are not yet fully understood. Many constituents of the nanoparticles are considered toxic or at least hazardous, including polycyclic aromatic hydrocarbons (PAHs) and heavy metal compounds, in addition to gaseous pollutants present in the aerosol fraction, such as NOx, SO and ozone.

Mithramycin and its analogs: Molecular features and antitumor action.

The antitumor antibiotic mithramycin A (MTA) binds to G/C-rich DNA sequences in the presence of dications. MTA inhibits transcription regulated by the Sp1 transcription factor, often enhanced during tumor development. It shows antitumor activity, but its clinical use was discontinued due to toxic side effects.

Efficient removal of toxicity associated to wastewater treatment plant effluents by enhanced Soil Aquifer Treatment.

The regeneration of wastewater has been recognized as an effective strategy to counter water scarcity. Nonetheless, Wastewater Treatment Plant (WWTP) effluents still contain a wide range of contaminants of emerging concern (CECs) even after water depuration. Filtration through Soil Aquifer Treatment (SAT) systems has proven efficient for CECs removal although the attenuation of their associated biological effects still remains poorly understood.

Linking the use of reclaimed water to indicators of crop stress by metabolomic and transcriptomic analyses. A tool to compare water irrigation quality.

The occurrence of contaminants of emerging concern (CECs) or heavy metals in reclaimed water used for agricultural irrigation may affect crop morphology and physiology. Here, we analyzed lettuce (Lactuca sativa) grown in outdoor lysimeters and irrigated with either tap water, used as a control, or reclaimed water: CAS-reclaimed water, an effluent from a conventional activated sludge system (CAS) followed by chlorination and sand filtration, or MBR-reclaimed water, an effluent from a membrane biological reactor (MBR). Chemical analyses identified seven CECs in the reclaimed waters, but only two of them were detected in lettuce (carbamazepine and azithromycin).

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk.

Environmental toxicogenomics aims to collect, analyze and interpret data on changes in gene expression and protein activity resulting from exposure to toxic substances using high-performance omics technologies. Molecular profiling methods such as genomics, transcriptomics, proteomics, metabolomics, and bioinformatics techniques, permit the simultaneous analysis of a multitude of gene variants in an organism exposed to toxic agents to search for genes prone to damage, detect patterns and mechanisms of toxicity, and identify specific gene expression profiles that can provide biomarkers of exposure and risk. Compared to previous approaches to measuring molecular changes caused by toxicants, toxicogenomic technologies can improve environmental risk assessment while reducing animal studies.

Inoculation Improves Nutrient Uptake and Physiological Activity in Sugarcane under Drought Stress.

Sugarcane ( spp.) is one of the most important crops in the world. Throughout the sugarcane's growth stages, periods of drought are common, causing detrimental effects on plant growth.

Dynamics of Macronutrient Uptake and Removal by Modern Peanut Cultivars.

The productive potential of new peanut cultivars has increased over the years in relation to old cultivars, especially when compared with ones with upright growth habit. Thus, the requirement for macronutrients for these new cultivars may also have increased, making the existing fertilizer recommendation tables obsolete, thus increasing the need for further studies measuring the real macronutrient requirements of these new peanut cultivars. Our study aimed to evaluate the growth patterns and the macronutrient absorption rate throughout the biological cycle of three modern runner peanut cultivars, as well as the potential for producing dry matter, pods, and kernels, and their respective macronutrient accumulations.

Long-Term Lime and Phosphogypsum Amended-Soils Alleviates the Field Drought Effects on Carbon and Antioxidative Metabolism of Maize by Improving Soil Fertility and Root Growth.

Long-term surface application of lime (L) and/or phosphogypsum (PG) in no-till (NT) systems can improve plant growth and physiological and biochemical processes. Although numerous studies have examined the effects of L on biomass and plant growth, comprehensive evaluations of the effects of this practice on net CO assimilation, antioxidant enzyme activities and sucrose synthesis are lacking. Accordingly, this study examined the effects of long-term surface applications of L and PG on soil fertility and the resulting impacts on root growth, plant nutrition, photosynthesis, carbon and antioxidant metabolism, and grain yield (GY) of maize established in a dry winter region.

Magnesium Foliar Supplementation Increases Grain Yield of Soybean and Maize by Improving Photosynthetic Carbon Metabolism and Antioxidant Metabolism.

(1) Background: The aim of this study was to explore whether supplementary magnesium (Mg) foliar fertilization to soybean and maize crops established in a soil without Mg limitation can improve the gas exchange and Rubisco activity, as well as improve antioxidant metabolism, converting higher plant metabolism into grain yield. (2) Methods: Here, we tested foliar Mg supplementation in soybean followed by maize. Nutritional status of plants, photosynthesis, PEPcase and Rubisco activity, sugar concentration on leaves, oxidative stress, antioxidant metabolism, and finally the crops grain yields were determined.

Spatial patterns of avoidable fetal mortality and social deprivation.

Objective: To develop a social need index for stratification of municipalities and identification of priority areas for reducing fetal mortality.

Methods: ecological study, carried out in the state of Pernambuco, between 2010 and 2017. The technique of factor analysis by main components was used for the elaboration of the social need index.

Insights into DNA-drug interactions in the era of omics.

Despite the rise of sophisticated new targeting strategies in cancer chemotherapy, many classic DNA-binding drugs remain on the front line of the therapy against cancer. Based on examples primarily from the author's laboratory, this article reviews the capabilities of several DNA-binding drugs to alter gene expression. Research is ongoing about the molecular bases of the inhibition of gene expression and how alteration of the cellular transcriptome can commit cancer cells to die.

Laboratory Studies of Questing Behavior in Colonized Nymphal Amblyomma maculatum Ticks (Acari: Ixodidae).

Environmental factors affect host-seeking behavior in ticks. In this study, 80 nymphal Amblyomma maculatum Koch were released in an observation arena containing four different heights of broomsedge stems (Andropogon virginicus L.) anchored in sand.

Mean Airway Pressure As a Predictor of 90-Day Mortality in Mechanically Ventilated Patients.

Objectives: To determine the association between mean airway pressure and 90-day mortality in patients with acute respiratory failure requiring mechanical ventilation and to compare the predictive ability of mean airway pressure compared with inspiratory plateau pressure and driving pressure.

Design: Prospective observational cohort.

Setting: Five ICUs in Lima, Peru.

Premature, Opportune, and Delayed Weaning in Mechanically Ventilated Patients: A Call for Implementation of Weaning Protocols in Low- and Middle-Income Countries.

Objectives: Weaning protocols establish readiness-to-wean criteria to determine the opportune moment to conduct a spontaneous breathing trial. Weaning protocols have not been widely adopted or evaluated in ICUs in low- and middle-income countries. We sought to compare clinical outcomes between participants whose weaning trials were retrospectively determined to have been premature, opportune, or delayed based on when they met readiness-to-wean criteria.

Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study.

Background: Clinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the course of MV (ARDS after MV onset) are not well understood. We conducted an observational study in five Peruvian ICUs to characterize differences between ARDS at MV onset and after MV onset and identify risk factors for the development of ARDS after MV onset.

Methods: We consecutively enrolled critically ill patients with acute respiratory failure requiring at least 24 h of mechanical ventilation and followed them prospectively during the first 28 days and compared baseline characteristics and clinical outcomes by ARDS status.

Profile of hospitalizations in Pediatric Intensive Care Units of the Brazilian Unified Health System in the state of Pernambuco, Brazil.

In Brazil, the distribution of pediatric intensive care units (PICUs), causes of admission, costs incurred and how care is provided are still poorly understood. The objective was to describe the profile of hospitalizations in the PICUs of the Brazilian Unified Health System in the state of Pernambuco, in 2010. A cross-sectional study was performed, with 1,915 hospitalizations in the six PICUs, collected in the Hospital Information System.

MALDI-TOF analysis of blood serum proteome can predict the presence of monoclonal gammopathy of undetermined significance.

Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia that can progress to malignant multiple myeloma (MM). Specific molecular biomarkers to classify the MGUS status and discriminate the initial asymptomatic phase of MM have not been identified. We examined the serum peptidome profile of MGUS patients and healthy volunteers using MALDI-TOF mass spectrometry and developed a predictive model for classifying serum samples.

Challenging transcription by DNA-binding antitumor drugs.

Cancer has been associated with altered gene expression. Therefore, transcription and its regulation by transcription factors are considered key points to be explored in the pursuit of more efficient antitumor agents. This paper reviews the effects of DNA-binding drugs on the interaction between transcription factors and DNA, and it discusses recent advances in the understanding of the mechanisms by which small compounds interfere with the activity of transcription factors and gene expression.

Spatial analysis of reported new cases and local risk of leprosy in hyper-endemic situation in Northeastern Brazil.

Objective: To analyse the spatial distribution of the incidence of leprosy and identify areas at risk for occurrences of hyper-endemic disease in Northeastern Brazil.

Methods: Ecological study using municipalities as the analysis unit. Data on new cases of leprosy came from the Health Hazard Notification System (SINAN).

Morphometric Analysis of Adult Dermacentor parumapertus Neumann (Acari: Ixodidae) From Various Locations Within its Geographical Range.

Dermacentor parumapertus Neumann (Acari: Ixodidae), a tick primarily associated with rabbits which occurs over much of the western United States, has a fairly large north-to-south distribution, being found from central Idaho southward into northern Mexico. This mostly obscure tick species has recently been the focus of attention due to the discovery of a unique strain of Rickettsia parkeri associated with it which appears closely related to a Rickettsia sp. found in the Atlantic rainforest of Brazil.