Fujian Tablet Regulates the Foxo3a/GPX4 Axis to Promote Remyelination and Improve Motor Function in Ischemic Stroke.

Ethnopharmacological Relevance: Fujian Tablet (FJT), a traditional Chinese herbal compound formulation developed under the theoretical framework of "nourishing the liver and kidney, replenishing essence and marrow" , has been clinically applied for over two decades to treat post-stroke neurological deficits. Preliminary studies demonstrated its efficacy in improving motor function and promoting cervical spinal cord neuroaxonal growth in a middle cerebral artery occlusion (MCAO) rat model. Building upon these findings, this study integrates metabolomic evidence of Foxo3a-GPX4 axis activation to systematically elucidate Fujian Tablet's neurorestorative mechanisms through three interconnected pathways: regulation of ferroptosis, promotion of oligodendrocyte proliferation, and remyelination.

Huangkui capsules for diabetic nephropathy: Comprehensive review of efficacy and molecular mechanisms.

Background: The management of kidney diseases urgently needs additional therapeutic options. Encouraging evidence suggests the efficacy of Huangkui capsules (HKCs), a plant-derived traditional medicine, in treating various subtypes of nephropathy. However, current evidence is fragmented between clinical outcomes and mechanistic insights.

FGF5 alleviates ferroptosis in renal tubular epithelial cells by inducing mitophagy under in vitro ischemia-reperfusion-like injury.

Renal ischemic disease represents a severe clinical pathological condition commonly observed in acute kidney injury (AKI), renal transplantation, and kidney surgery. It leads to renal tubular epithelial cell damage, inflammatory responses, and cell death, potentially progressing to chronic kidney disease (CKD) or even renal failure, significantly impairing patients' quality of life and survival rates. Current therapeutic strategies for renal ischemia-reperfusion injury (IRI) include pharmacological interventions, cell therapy, and gene therapy, yet their efficacy remains limited and may be accompanied by adverse effects.

CsWRKY15 from tea plant promotes its auto-resistance when intercropped with chestnut.

To explore the role of WRKY transcription factors in resistance, a WRKY15 homologous gene, CsWRKY15, and its promoter were isolated from tea plants when intercropped with chestnut. CsWRKY15 expression was significantly induced by ethephon, polyethylene glycol (PEG), and low temperature. Notably, its expression was strongly induced by exogenous gibberellic acid (GA3).