Urinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks.

Formed through the partial burning of carbon-based materials, polycyclic aromatic hydrocarbons (PAHs) represent a prevalent class of environmental contaminants associated with significant human health risks. However, comprehensive exposure and health risk assessment remain lacked, specifically among the elderly population. This research involved carrying out five sequential surveys across a five-month period, with 76 healthy elderly individuals participating from Jinan, Shandong Province, to quantify urinary concentrations of 16 monohydroxylated PAHs (OH-PAHs) and their associated health risks.

Associations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study.

Polycyclic aromatic hydrocarbons (PAHs) have been increasingly implicated in metabolic disorders, including type 2 diabetes, yet their impact on glycometabolism in older adults remains unclear. This study investigated associations between urinary PAH metabolites and glycometabolic markers and explored underlying potential mechanisms among healthy older adults. In the China BAPE study, 70 healthy older participants were recruited and five monthly follow-up visits were conducted between September 2018 and January 2019, with the associations between six urinary PAH metabolites and five glycometabolic markers were examined in this study.

Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study.

Personal care products (PCPs) are ubiquitously present in the environment, and the associated health risks have been increasingly concerned worldwide. However, knowledge regarding exposure assessments of older adults to these chemicals and their health risks remains largely limited. In the present study, five repeated surveys involving 76 healthy older adults in Jinan, Shandong Province, were performed to quantify urinary exposure levels of 14 chemicals in PCPs.

Reproductive toxicity of bisphenol A and nitro-bisphenol A in male zebrafish at environmentally relevant concentrations.

Bisphenol A (BPA) is a well-known endocrine-disrupting pollutant that poses significant environmental challenges globally. However, the toxicity of nitro-BPA (NBPA), the primary transformation product of BPA, remains poorly understood. This study employs a multi-omics approach, integrating in silico and bioinformatics analyses, to investigate and compare the male reproductive toxicity of BPA and NBPA in male zebrafish exposed to environmentally relevant concentrations.

Melatonin alleviates cadmium toxicity by regulating root endophytic bacteria community structure and metabolite composition in apple.

The level of cadmium (Cd) accumulation in orchard soils is increasing, and excess Cd will cause serious damage to plants. Melatonin is a potent natural antioxidant and has a potential role in alleviating Cd stress. This study aimed to investigate the effects of exogenous melatonin on a root endophyte bacteria community and metabolite composition under Cd stress.

Dopamine alleviates cadmium stress in apple trees by recruiting beneficial microorganisms to enhance the physiological resilience revealed by high-throughput sequencing and soil metabolomics.

Dopamine has demonstrated promise as a stress-relief substance. However, the function of dopamine in Cd tolerance and its mechanism remains largely unknown. The current study was performed to investigate the mechanism of dopamine on alleviating apple Cd stress through regular application of CdCl and dopamine solution to potting soil.

Comparative Metagenomic and Metatranscriptomic Analyses Reveal the Response of Black Soldier Fly () Larvae Intestinal Microbes and Reduction Mechanisms to High Concentrations of Tetracycline.

Black soldier fly () larvae (BSFL) possess remarkable antibiotic degradation abilities due to their robust intestinal microbiota. However, the response mechanism of BSFL intestinal microbes to the high concentration of antibiotic stress remains unclear. In this study, we investigated the shift in BSFL gut microbiome and the functional genes that respond to 1250 mg/kg of tetracycline via metagenomic and metatranscriptomic analysis, respectively.

Exogenous melatonin alleviates apple replant disease by regulating rhizosphere soil microbial community structure and nitrogen metabolism.

Apple replant disease (ARD) is a common soil-borne disease afflicting apple plants. Melatonin is a broad-spectrum oxygen scavenger that plays a key role in alleviating stress-induced damage in plants. In this study, we aimed to determine whether adding melatonin to replant soil can promote plant growth by improving the rhizosphere soil environment and nitrogen metabolism.

Biochar Can Improve Absorption of Nitrogen in Chicken Manure by Black Soldier Fly.

(1) Background: There is growing interest in using insects to treat nutrient-rich organic wastes, such as the black soldier fly (BSF), one of the most efficient organic waste recyclers for upcycling nutrients into the food system. Although biochar (BC) was shown to enhance nutrient retention and the final product quality during the composting of livestock and poultry manure in many previous studies, little information is available on the effect of BC on livestock manure bioconversion by black soldier fly larvae (BSFL). (2) Methods: This study investigated the effect of adding a small amount of BC to chicken manure (CM) on the bioconversion system of the black soldier fly (including NO and NH emissions and the final distribution of nitrogen during the treatment process).

Integrated Analysis of MicroRNA and mRNA Expression Profiles in the Fat Bodies of MbMNPV-Infected .

MicroRNAs (miRNAs), are a novel class of gene expression regulators, that have been found to participate in regulating host-virus interactions. However, the function of insect-derived miRNAs in response to virus infection is poorly understood. We analyzed miRNA expression profiles in the fat bodies of () infected with multiple nucleopolyhedroviruses (MbMNPV).

Ionomic Combined with Transcriptomic and Metabolomic Analyses to Explore the Mechanism Underlying the Effect of Melatonin in Relieving Nutrient Stress in Apple.

Nutrient stress harms plant growth and yield. Melatonin is a biologically active, multifunctional hormone that relieves abiotic stress in plants. Although previous studies have shown that melatonin plays an important role in improving nutrient-use efficiency, the mechanism of its regulation of nutrient stress remains unclear.

EEAM 10B Strengthens Nutrient Metabolic Process in Black Soldier Fly Larvae () Changing Gut Microbiome and Metabolic Pathways.

Insects are a potential alternative protein source to solve the food shortage crisis. Previous studies have illustrated that probiotics can improve the substrate conversion efficiency of insects and increase insect protein content. However, the effects of probiotics on insect physiology and nutrient metabolism are still not well understood.

A meta-analysis of early oral refeeding and quickly increased diet for patients with mild acute pancreatitis.

Background/aim: The objective of the study is to clarify whether early oral refeeding (EORF) and quickly increasing diet (QID) are of benefit to patients with mild acute pancreatitis compared with a traditional oral refeeding strategy.

Materials And Methods: Studies were searched in PubMed, Cochrane library, ScienceDirect, SpringerLink, China Biology Medicine disc and Embase. A meta-analysis was then performed, using relapse of abdominal pain, nausea/vomiting, and length of hospital stay (LOHS) as the evaluation indices.

Accumulation of Citrulline by Microbial Arginine Metabolism during Alcoholic Fermentation of Soy Sauce.

Citrulline, the major precursor of ethyl carbamate in soy sauce, is an intermediate catabolite of arginine produced by bacteria present in soy sauce moromi mash. Pediococcus acidilactici is responsible for the formation of citrulline during the lactic acid fermentation process of soy sauce. However, citrulline accumulation during the alcoholic fermentation process and the corresponding bacteria involved have not been identified.

Characterization of a Bacillus amyloliquefaciens strain for reduction of citrulline accumulation during soy sauce fermentation.

Objectives: To reduce the amount of citrulline produced by arginine-consuming bacteria in the moromi mash during soy sauce production.

Results: Bacillus amyloliquefaciens JY06, a salt-tolerant strain with high arginine consumption ability and low citrulline accumulation capacity, was isolated from moromi mash. The concentration of citrulline was decreased from 26.

[Metabolism of ethyl carbamate precursors in soy sauce by Zygosaccharomyces rouxii ZQ02Metabolism of ethyl carbamate precursors in soy sauce by Zygosaccharomyces rouxii ZQ02].

Objective: To study nitrogen metabolism of Zygosaccharomyces rouxii and its relationship with the formation of soy sauce ethyl carbamate precursors.

Methods: Z. rouxii ZQ02 was cultivated with single source of nitrogen, preferred nitrogen sources or under salt stress, to investigate its ability of using arginine, citrulline and urea.

The arginine deiminase pathway of koji bacteria is involved in ethyl carbamate precursor production in soy sauce.

Ethyl carbamate (EC) is a group 2A carcinogen generated from a few precursors in many fermented foods and alcoholic beverages. Citrulline, urea, carbamoyl phosphate, and ethanol are common precursors detected in fermented foods. In this study, citrulline was proved to be the main EC precursor in soy sauce, which was found to be accumulated in moromi mash period and correlated with the utilization of arginine by koji bacteria.

Lethal effect of a hyperthermic CO₂ pneumoperitoneum on gastric cancer cells.

Objectives: We investigated the lethal effect of a hyperthermic CO₂ pneumoperitoneum on gastric cancer cells. This could form the theoretical basis for further studies of the feasibility and safety of inflating hyperthermic CO₂ in the abdominal cavity of gastric cancer patients during laparoscopy.

Methods: An in vitro hyperthermic CO₂ pneumoperitoneum experimental model was built, where gastric cancer cell line SGC-7901 cells were grouped according to temperature.

High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients.

High expressions of galectin-1 and vascular endothelial growth factor (VEGF) are correlated with biological behavior in some cancers. The aim of this study is to evaluate the expressions of galectin-1 and VEGF in gastric cancer and investigate their relationships with clinicopathological factors and prognostic significance. Immunohistochemical analyses for galectin-1 and VEGF expression were performed on 108 cases of gastric cancer.