Nanozyme-mediated high-entropy-driven photothermally enhanced tumor catalytic therapy.

Nanozyme-mediated catalytic therapy has emerged as a promising strategy for antitumor treatment, but it is imperative to further improve the catalytic efficiency of nanozymes to achieve potentiated antitumor efficacy. Single-phase high-entropy (HE) nanozymes with desirable enzyme-like catalytic activity and photothermal properties are appealing for enhancing the efficacy of catalytic therapy but have remained synthetically challenging. As a proof-of-concept demonstration, we herein prepared a single-phase HE Prussian blue analogue (HEPBA) using a conventional coprecipitation method.

Combined exposure to atrazine and phoxim exacerbated the alterations of enzyme activity and abnormal gene expression in earthworms (Eisenia fetida).

Multiple pesticides often coexist in soil, potentially leading to interactions among their components, these may detrimentally impact soil organisms. This study assessed the potential risks posed by simultaneous exposure to atrazine (ATR) and phoxim (PHO) on enzyme and transcription levels in earthworms (Eisenia fetida). The results revealed that ATR exhibited higher acute toxicity towards E.

Three-phase extraction of polysaccharide from : Process optimization, structural characterization and bioactivities.

The isolation of polysaccharide (SRP) by three-phase extraction was optimized, and its structure and biological activities were identified. The optimal extraction conditions were: mass fraction of ammonium sulfate, 20%; volume ratio of sample solution to t-butanol, 1:1.5; extraction temperature, 35°C.

A novel AIE-active imidazolium macrocyclic ratiometric fluorescence sensor for pyrophosphate anion.

An imidazolium bridged macrocyclophane was synthesized as a ratiometric fluorescence sensor with aggregation-induced emission (AIE) characteristic to detect pyrophosphate anion with high selectivity among various anions. In the presence of zinc ion, macrocyclophane can form aggregates through complexation with pyrophosphate anion and emit ratiometric fluorescence, resulting from an enhancement in its aggregate-state emission and a reduction in its monomer emission. This AIE-active macrocycle showed great potential as a ratiometric fluorescence receptor.