Co-resistance and plasmid-mediated co-dissemination of florfenicol and azithromycin resistance in non-O157 Shiga toxin-producing Escherichia coli from cattle in Xinjiang, China.

Background: Florfenicol is a critical antibiotic used in cattle to manage respiratory infections, while azithromycin is recommended for treating early-stage Shiga toxin-producing Escherichia coli (STEC) infections. This study focused on examining the co-resistance and mechanisms of co-dissemination of resistance to florfenicol and azithromycin in 367 non-O157 STEC strains isolated from cattle in Xinjiang between 2015 and 2023.

Results: Among these isolates, 16.

Anode-Cathode Synergistic Filter Activating Peroxymonosulfate at Multiple Active Sites for Highly Efficient and Economical Water Purification.

Developing an efficient dual-electrode system for peroxymonosulfate (PMS) activation is essential to expand the scope for wastewater treatment and solve issues of low treatment capacity, poor mineralization, and high energy consumption. This study proposed an oxygen vacancy-mediated LaCoO-modified TiO (LCVTO) anode membrane and in situ grown nanocarbon-modified carbon felt (C/CF) cathode to coactivate PMS, achieving 100% sulfamethoxazole (SMX) elimination in 37.3 s.

FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Accumulating evidence suggests that epigenetic dysregulation contributes to the initiation and progression of HCC. We aimed to investigate key epigenetic regulators that contribute to tumorigenesis and progression, providing a theoretical basis for targeted therapy for HCC.

Learning motif features and topological structure of molecules for metabolic pathway prediction.

Metabolites serve as crucial biomarkers for assessing disease progression and understanding underlying pathogenic mechanisms. However, when the metabolic pathway category of metabolites is unknown, researchers face challenges in conducting metabolomic analyses. Due to the complexity of wet laboratory experimentation for pathway identification, there is a growing demand for predictive methods.

The Virulence Gene and Drug Resistance Analysis of Shiga Toxin-Producing from Diarrhea Calves in Xinjiang, China.

This investigation aimed to examine the virulence genes and antimicrobial resistance profiles of Shiga toxin-producing (STEC) strains found in diarrheal calves in Xinjiang between 2016 and 2022. A total of 800 samples, including 232 fecal and 568 rectal swabs from calves under 2 months old with diarrhea, were analyzed for Shiga toxin (Stx)-encoding genes using polymerase chain reaction. The study characterized the isolates based on their subtypes, virulence genes, O serogroups, phylogenetic groups, hemolytic phenotypes, antibiotic resistance, and resistance genes.

The Mobility of Mo during Microbially Mediated Ferrihydrite Phase Transformation.

Molybdenum (Mo) is an essential nutrient for almost all organisms. However, at high concentrations, it can be toxic to animals and plants. This study investigated the interactions of Mo(VI) with iron oxyhydroxides during ferrihydrite bioreduction in the presence of Fe(III)-reducing .

Application of omics technologies in studies on antitumor effects of Traditional Chinese Medicine.

Traditional Chinese medicine (TCM) is considered to be one of the most comprehensive and influential form of traditional medicine. It plays an important role in clinical treatment and adjuvant therapy for cancer. However, the complex composition of TCM presents challenges to the comprehensive and systematic understanding of its antitumor mechanisms, which hinders further development of TCM with antitumor effects.

n-hexane extract suppressed breast cancer progression through induction of G0/G1 phase arrest and apoptotic cell death by inhibiting the Cyclin D1/CDK4-Rb signaling pathway.

Background: Breast cancer (BC) is one of the most frequently observed malignancies globally, yet drug development for BC has been encountering escalating challenges. is derived from the dried resin of (T. Nees) Engl.

Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin.

Breast cancer (BC) remains a significant health concern for women globally, prompting the relentless pursuit of novel therapeutic modalities. As a traditional Chinese medicine, Boswellia carterii has been extensively used to treat various cancers, such as BC. However, the anti-BC effect and underlying mechanism of Boswellia carterii remain largely unclear.

Clustering single-cell RNA sequencing data via iterative smoothing and self-supervised discriminative embedding.

Single-cell transcriptome sequencing (scRNA-seq) is a high-throughput technique used to study gene expression at the single-cell level. Clustering analysis is a commonly used method in scRNA-seq data analysis, helping researchers identify cell types and uncover interactions between cells. However, the choice of a robust similarity metric in the clustering procedure is still an open challenge due to the complex underlying structures of the data and the inherent noise in data acquisition.

First identification and isolation of equine herpesvirus type 1 in aborted fetal lung tissues of donkeys.

Background: Equine herpesvirus type 1 (EHV-1) is commonly associated with horse abortion. Currently, there are no reported cases of abortion resulting from EHV-1 infection in donkeys.

Results: This was the first survey-based study of Chinese donkeys.

mediates PM-induced endothelial dysfunction via crosstalk between bronchial epithelial and endothelial cells.

Objective: PM is closely linked to vascular endothelial injury and has emerged as a major threat to human health. Our previous research indicated that exposure to PM induced an increased release of from the bronchial epithelium. However, the role of in PM-induced endothelial injury remains elusive.

Bioproduction of cerium-bearing magnetite and application to improve carbon-black supported platinum catalysts.

Background: Biogeochemical processing of metals including the fabrication of novel nanomaterials from metal contaminated waste streams by microbial cells is an area of intense interest in the environmental sciences.

Results: Here we focus on the fate of Ce during the microbial reduction of a suite of Ce-bearing ferrihydrites with between 0.2 and 4.

Donkey-like kirkovirus is associated with diarrhea in piglets.

Kirkovirus (kirV), a seemingly novel virus family, has been found in horses and donkeys. The study's objectives are to investigate the presence of the virus in swine. In this study, donkey-like kirV was detected in rectal swabs of piglets with diarrhea, and the positive rate was found to be 100% (149/149).

The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives.

The gut microbiota, known as the "forgotten organ" and "human second genome," comprises a complex microecosystem. It significantly influences the development of various tumors, including colorectal, liver, stomach, breast, and lung cancers, through both direct and indirect mechanisms. These mechanisms include the "gut-liver" axis, the "lung-intestine" axis, and interactions with the immune system.

Identification of neuropathogenic Varicellovirus equidalpha1 as a potential cause of respiratory disease outbreaks among horses in North Xinjiang, China, from 2021-2023.

Background: Varicellovirus equidalpha1 (formerly Equid alphaherpesvirus 1, EqAHV-1) is among the most important viruses responsible for respiratory disease outbreaks among horses throughout the world. No reports to date have detailed the association between EqAHV-1 and respiratory disease among horses in China. This study described one such outbreak among a population of horses in north Xinjiang that occurred from April 2021 - May 2023.

Binding Free Energy Calculation Based on the Fragment Molecular Orbital Method and Its Application in Designing Novel SHP-2 Allosteric Inhibitors.

The accurate prediction of binding free energy is a major challenge in structure-based drug design. Quantum mechanics (QM)-based approaches show promising potential in predicting ligand-protein binding affinity by accurately describing the behavior and structure of electrons. However, traditional QM calculations face computational limitations, hindering their practical application in drug design.

Interfering with the AKT/mTOR/STAT3/ID1 signaling axis with usenamine A restrains the proliferative and invasive potential of human hepatocellular carcinoma cells.

Background: Usenamine A, a novel natural compound initially isolated from the lichen Usnea longissima, has exhibited promising efficacy against hepatoma in prior investigation. Nevertheless, the underlying mechanisms responsible for its antihepatoma effects remain unclear. Furthermore, the role of the AKT/mechanistic target of the rapamycin (mTOR)/signal transducer and activator of transcription 3 (STAT3)/inhibitor of differentiation/DNA binding 1 (ID1) signaling axis in hepatocellular carcinoma (HCC), and the potential anti-HCC effects of drugs targeting this pathway are not well understood.

Degradation of atrazine by electro-peroxone enhanced by Fe and N co-doped carbon nanotubes with simultaneous catalysis of HO and O.

Fe and N co-doped carbon nanotubes (Fe-N-CNT) was synthesized and attempted as efficient heterogeneous catalysts for simultaneous catalysis of HO and O to improve electro-peroxone (Fe-N-CNT/EP) process efficiency for atrazine (ATZ) degradation. The removal and mineralization of ATZ was significantly enhanced, obtaining the degradation rate constant (k) by Fe-N-CNT/EP (0.23 min) about two times that of EP (0.

Abortion storm of Yili horses is associated with Equus caballus papillomavirus 2 variant infection.

Nine different species of Equus caballus papillomavirus (EcPV) and three bovine papillomaviruses (BPVs) have been reported to infect horses. However, there are few descriptions of such infections in China. In our pioneer study on Chinese horses, we identified EcPV-2 in the nasal swabs (4/230, 1.

A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis.

Ferroptosis is a non-apoptotic form of regulated cell death characterized by iron-dependent lipid peroxidation. It can be triggered by various mechanisms, including the glutathione peroxidase 4 (GPX4)-glutathione (GSH) axis, iron metabolism, lipid metabolism, the GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH4) pathway, and the ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 axis. The redox balance is disrupted when ferroptosis occurs in cells, which is fatal to cancer cells.

Metal Exposure during Early Pregnancy and Risk of Gestational Diabetes Mellitus: Mixture Effect and Mediation by Phospholipid Fatty Acids.

Despite existing studies exploring the association between metal exposure and gestational diabetes mellitus (GDM), most of them have focused on a single metal or a small mixture of metals. Our prospective work investigated the joint and independent effects of early gestational exposure to 17 essential and nonessential metals on the GDM risk and potential mediation by plasma phospholipid fatty acids (PLFAs) based on a nested case-control study established with 335 GDM cases and 670 randomly matched healthy controls. The Bayesian kernel machine regression (BKMR) and quantile g-computation analyses demonstrated a joint effect from metal co-exposure on GDM risk.

A pilot scale of electrochemical integrated treatment technology and equipment driven by solar energy for decentralized domestic sewage treatment.

Based on the natural air diffusion electrode (NADE) cathode, a solar-driven electrochemical integrated sewage treatment technology and equipment in a pilot scale was developed to treat dispersed rural wastewater. The non-aeration NADE had efficient and stable HO production performance, maintaining the HO output between 1474 and 1535 mg h within 50 h with the current efficiency of 77.4%-80.