Associations Between Fatigue and Cardiovascular-Kidney-Metabolic Syndrome and the Mediating Role of Inflammation.

Purpose: Fatigue is common in many chronic diseases. The aim of this cross-sectional study was to investigate the association between fatigue and cardiovascular-kidney-metabolic syndrome (CKM) in Chinese asymptomatic individuals undergoing routine health screenings and to explore the mediating role of inflammation.

Patients And Methods: The data of 4349 individuals were included in this cross-sectional study.

Perfect vortex beam propagation through jet engine turbulence considering incident mode.

When employing an airborne laser communication system in a drone swarm, it is inevitable that laser beams carrying information intersect with the airborne wake region during their propagation, and the laser may traverse jet engine turbulence at various angles and positions. Nevertheless, previous research in this area typically assumed that the laser beams would propagate perpendicular to the jet engine turbulence. To address this problem, we have established what we believe to be a novel turbulence model that takes incident modes into account.

Development and validation of mPCR-CEFA for detecting multiple deletion and non-deletion thalassemia genotypes.

Background: Thalassemia is a common hereditary blood disorder caused by genetic variants in globin genes, leading to abnormal hemoglobin production. Rapid and accurate genotyping is essential for molecular screening and prenatal genetic diagnosis to prevent the birth of individuals with severe forms of the disease.

Methods: We developed a multiplex PCR-capillary electrophoresis fragment analysis (mPCR-CEFA) method to detect 16 α-thalassemia and 24 β-thalassemia genotypes simultaneously.

Obstacle inversion based on the self-healing property of structured light.

The self-healing property of structured light allows it to partially recover its original intensity distribution during propagation after a portion of its intensity has been obscured by an obstacle. In this study, we present a thorough investigation of the self-healing property of perfect vortex beam (PVB) within structured light. Firstly, we investigated the impact of obstacles of varying sizes and shapes on PVB at different stages of propagation, leading to a key conclusion the self-healing process of PVB can be divided into two parts: the self-healing of the obstructed region and the damage in the unstructured region.

Wide band optical diode based on passive white light cavities.

Usually, most optical diodes with high nonreciprocal transmission ratio were accompanied with high insertion loss. The diode made of the asymmetry cavity filled with two-level atoms can simultaneously possess high nonreciprocal transmission ratio and low insertion loss, because the cavity can lower insertion loss and the bistability of the atom can enhance nonreciprocal transmission ratio. However, such diodes can only operate in a very narrow frequency band.

Development of a four autophagy-related gene signature for active tuberculosis diagnosis.

Background: Tuberculosis (TB) diagnostics urgently require non-sputum biomarkers to address the limitations of conventional methods in distinguishing active TB (ATB) from latent infection (LTBI), healthy controls (HCs), and TB-mimicking diseases (ODs, other diseases).

Methods: Transcriptomic data from GSE83456 and GSE152532 were combined to form the selection dataset. Marker genes were identified from differentially expressed autophagy-related genes using a Random Forest classifier.

Viridicatol from the Deep-Sea-Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway.

As an enticing bone anabolic target, short-term inhibition of Schnurri-3 (SHN3) resulted in high-bone mass due to augmented osteoblast activity. However, no studies are conducted to identify natural products targeting SHN3 inhibition. Herein, a screening strategy for the discovery of marine compounds that facilitate osteoblast differentiation by targeting SHN3 silencing is presented.

Regulation of 5-fluorouracil-induced intestinal damage by the interleukin-23/interleukin-22 axis in chemotherapy.

5-Fluorouracil (5-FU) is a primary chemotherapeutic agent for gastrointestinal cancers, known to improve survival but also cause significant intestinal damage, affecting patient quality of life. This study investigated the IL-23-IL-22 axis's role in moderating 5-FU-induced intestinal damage. We analyzed paracancerous tissue damage in colon cancer patients with different Tumor Regression Grade (TRG) and found a direct correlation between TRG and tissue damage severity, indicating that higher chemotherapy effectiveness is linked to increased tissue damage.

The influence of thermal discharge from power plants on the biogeochemical environment of Daya Bay during high primary productivity seasons.

Accurate assessments of the impact of thermal discharge from power plants on the marine ecosystem remains a significant challenge. This study provided high-resolution observation during two high-productivity seasons to investigated the biogeochemical impacts of thermal discharge in Dapeng Cove, Daya Bay. The surface footprint of the thermal plume was hardly discernible during summer, likely due to intense solar heating of the water surface, but rapid biogeochemical decomposition of organisms still occurs.

Three transmission properties of the perfect vortex beam.

We propose that a perfect vortex beam (PVB) exhibits three major properties, namely, perfect property, self-focusing property, and self-healing property. Our experimental results indicate that PVB manifests superb perfect property, impervious to the influence of orbital angular momentum during the anti-diffraction stage, but ultimately transitioning to the self-focusing property during the self-focusing stage. The self-focusing property of PVB can significantly augment its transmission performance and be tailored through adjustments to the ring radius, ring thickness, and self-focusing ratio to meet the needs of various optical applications.

Single-cell resolution profiling of the immune microenvironment in primary and metastatic nasopharyngeal carcinoma.

Background: Nasopharyngeal carcinoma (NPC) is an assertive malignancy with partially understood underlying mechanisms, urging further study into its diverse and dynamic tumor microenvironment (TME) to bolster diagnosis, treatment, and prognostic accuracy.

Aims: To track the evolutionary route of metastasis, here we perform a yielding scRNA-seq data from 24 primary carcinoma, 7 peripheral blood mononuclear cell (PBMC) nasopharyngeal carcinoma, and 7 metastatic carcinoma patients' sample.

Materials And Methods: Following high quality control and filtration, a total of 292,298 cells from these tumors were classified into 10 clusters: T cells, B cells, Macrophages/Monocytes, Natural Killer (NK) cells, Plasma cells, plasmacytoid Dendritic Cells, Migratory Dendritic Cells, Mast cells, Cancer-Associated Fibroblasts, and Epithelial cells.

Zinc finger protein 180 induces an apoptotic phenotype by activating METTL14 transcriptional activity in colorectal cancer.

Zinc finger protein 180 (ZNF180) is a multifunctional protein that interacts with nucleic acids and regulates various cellular processes; however, the function of ZNF180 in colorectal cancer (CRC) remains unclear. The present study investigated the role and function of ZNF180 in CRC, and aimed to reveal the underlying molecular mechanism. The results revealed that ZNF180 was downregulated in CRC tissues and was associated with a good prognosis in patients with CRC.

Integrating metabolomics and network pharmacology analysis to explore mechanism of Pueraria lobata against pulmonary fibrosis: Involvement of arginine metabolism pathway.

Ethnopharmacological Relevance: Pueraria lobata (Willd.) Ohwi is a typical medicinal and edible plant with a long application history in China and Southeast Asia. As a widely used traditional medicine, P.

Manual acupuncture ameliorates inflammatory pain by upregulating adenosine A receptor in complete Freund's adjuvant-induced arthritis rats.

Background: Adenosine A receptor (AR) exerts analgesic, anti-inflammatory, and anti-nociceptive effects. In this study, we determined the analgesic mechanism of manual acupuncture (MA) in rats with complete Freund's adjuvant (CFA)-induced arthritis and explored whether MA ameliorates inflammation in these rats by upregulating AR.

Methods: Sixty Sprague Dawley (SD) rats were randomly divided into the following groups: Control, CFA, CFA + MA, CFA + sham MA, CFA + MA + DMSO, CFA + MA + IB-MECA, and CFA + MA + Reversine groups.

Malignancy diagnosis of liver lesion in contrast enhanced ultrasound using an end-to-end method based on deep learning.

Background: Contrast-enhanced ultrasound (CEUS) is considered as an efficient tool for focal liver lesion characterization, given it allows real-time scanning and provides dynamic tissue perfusion information. An accurate diagnosis of liver lesions with CEUS requires a precise interpretation of CEUS images. However,it is a highly experience dependent task which requires amount of training and practice.

An injectable collagen peptide-based hydrogel with desirable antibacterial, self-healing and wound-healing properties based on multiple-dynamic crosslinking.

Conventional collagen-based hydrogels as wound dressing materials are usually lack of antibacterial activity and easily broken when encountering external forces. In this work, we developed a collagen peptide-based hydrogel as a wound dressing, which was composed of adipic acid dihydrazide functionalized collagen peptide (Col-ADH), oxidized dextran (ODex), polyvinyl alcohol (PVA) and borax via multiple-dynamic reversible bonds (acylhydrazone, amine, borate ester and hydrogen bonds). The injectable hydrogel exhibited satisfactory self-healing ability, antibacterial activity, mechanical strength, as well as good biocompatibility and biodegradability.

Inhibition of FABP5 attenuates inflammatory bowel disease by modulating macrophage alternative activation.

Fatty acid binding protein 5 (FABP5) is an intracellular chaperone of fatty acid molecules that regulates lipid metabolism and cell growth. However, its role in intestinal inflammation remains enigmatic. Through examination of human tissue samples and single-cell data, we observed a significant upregulation of FABP5 within the mucosa of patients afflicted with ulcerative colitis (UC) and Crohn's disease (CD), predominantly localized in intestinal macrophages.

Nonlinear topological laser on the non-Hermitian Haldane model with higher-order corner states.

The non-Hermitian skin effect (NHSE) on the non-Hermitian Haldane model with gain and loss on the honeycomb lattice with the outline of a triangle is discussed. The NHSE only occurs on the edge of the lattice, transforming the edge modes into the higher-order corner modes. The NHSE can also occur on a lattice with only loss, which can be treated as a lattice with gain and loss as well as a global loss added to it.

Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway.

The potential of marine natural products as effective drugs for osteoporosis treatment is an understudied area. In this study, we investigated the ability of lead compounds from deep-sea-derived Penicillium solitum MCCC 3A00215 to promote bone formation in vitro and in vivo. We found that penicopeptide A (PPA) promoted osteoblast mineralization among bone marrow mesenchymal stem cells (BMSCs) in a concentration-dependent manner, and thus, we selected this natural peptide for further testing.

Enhanced Performance of GaAs Metal-Oxide-Semiconductor Capacitors Using a TaON/GeON Dual Interlayer.

In this work, a dual interfacial passivation layer (IPL) consisting of TaON/GeON is implemented in GaAs metal-oxide-semiconductor (MOS) capacitors with ZrTaON as a high-k layer to obtain superior interfacial and electrical properties. As compared to the samples with only GeON IPL or no IPL, the sample with the dual IPL of TaON/GeON exhibits the best performance: low interface-state density (1.31 × 10 cm eV), small gate leakage current density (1.

Passive white light cavities with metal coatings.

White light cavities with broadband resonance are usually filled with negative dispersion medium, which inevitably leads to gain. In this article, pure passive white light cavities are designed, in which negative dispersion medium is no longer necessary. Theoretically, if the reflection phase of the cavity wall can exhibit a negative dispersion slope, then it can also satisfy white light cavities conditions without medium.

Intrinsic brain activity is increasingly complex and develops asymmetrically during childhood and early adolescence.

A large body of evidence suggests that brain signal complexity (BSC) may be an important indicator of healthy brain functioning or alternately, a harbinger of disease and dysfunction. However, despite recent progress our current understanding of how BSC emerges and evolves in large-scale networks, and the factors that shape these dynamics, remains limited. Here, we utilized resting-state functional near-infrared spectroscopy (rs-fNIRS) to capture and characterize the nature and time course of BSC dynamics within large-scale functional networks in 107 healthy participants ranging from 6-13 years of age.