Positive preoperative circulating tumor cells level associated with lymph node metastasis in papillary thyroid carcinoma patients with capsular invasion.

Objective: Capsular invasion in papillary thyroid cancer(PTC) refers to thyroid cancer penetrating the capsule without attaching to the surrounding tissue. Patients with and without capsular invasion may differ in the likelihood of lymph node metastasis(LNM). The purpose of this study is to study the relationship between circulating tumor cells(CTCs) and LNM in PTC with or without capsular invasion.

Exploring the role of EBV ZEBRA antibody levels in papillary thyroid cancer risk and drug resistance.

Papillary thyroid carcinoma (PTC), the most prevalent thyroid malignancy worldwide, exhibits an increasing incidence globally despite its generally favorable prognosis. Although its etiology remains partially elucidated, recent investigations have implicated specific pathogens-notably Epstein-Barr virus (EBV)-in PTC pathogenesis. To rigorously evaluate the causal relationship between EBV ZEBRA antibody levels and PTC risk, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis leveraging large-scale genome-wide association study (GWAS) data.

Bidirectional relationship between platelet count and skin cancer: tumor drug resistance mechanisms.

Background: Platelets (PLT) play a crucial role in tumor progression, including tumor growth, metastasis, and immune evasion. However, the relationship between PLT count and specific skin cancer subtypes, particularly melanoma skin cancer (MSC) and non-melanoma skin cancer (NMSC), remains poorly understood. Clarifying this association could identify potential biomarkers and therapeutic targets for personalized treatments.

Preoperative circulating tumor cells level is associated with lymph node metastasis in patients with unifocal papillary thyroid carcinoma.

Objective: Unifocal papillary thyroid carcinoma (PTC) refers to thyroid cancer that has only one isolated lesion, it has also the possibility of lymph node metastasis (LNM). Circulating tumor cell (CTC) has been used to assist in the assessment of tumor progression, but the relationship between CTCs levels and LNM in unifocal PTC patients is unclear.

Methods: The clinical records (age, gender, Hashimoto's thyroiditis, thyroid function, tumor size, invaded capsule (thyroid cancer penetrating the capsule), clinical stage, and LNM) of unifocal PTC patients in Meizhou People's Hospital were analyzed retrospectively.

Pretreatment level of circulating tumor cells is associated with lymph node metastasis in papillary thyroid carcinoma patients with ≤ 55 years old.

Objective: To investigate the relationship of pretreatment of circulating tumor cells (CTCs) and cervical lymph node metastasis (LNM) (central LNM (CLNM) and lateral LNM (LLNM)) in papillary thyroid carcinoma (PTC) patients with ≤ 55 years old.

Methods: Clinicopathological data (CTCs level, Hashimoto's thyroiditis, thyroid function, multifocal, tumor size, invaded capsule, clinical stage, and LNM) of 588 PTC patients with ≤ 55 years old were retrospectively collected. The relationship of CLNM, LLNM and the clinical features of patients was analyzed.

Causal associations between circulating protein ratios and drug resistance in papillary thyroid cancer: a Mendelian randomization study.

Objective: Circulating protein level ratios (CPLRs) may play a crucial role in tumor progression and drug resistance by mediating interactions within the tumor microenvironment. This study aims to investigate the causal associations between CPLRs and papillary thyroid cancer (PTC), focusing on their potential implications in drug resistance mechanisms.

Methods: Genetic data for 2821 CPLRs were obtained from the GWAS and FinnGen databases.

Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance.

The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development and progression. This study aimed to explore the potential mediating role of IC in the causal relationship between GM and thyroid cancer (TC) using Mendelian randomization (MR) analysis. Data from genome-wide association studies (GWAS) encompassing 473 GM species, 731 IC types, and TC were utilized.

Preoperative High Level of Circulating Tumor Cells is an Independent Risk Factor for Central Lymph Node Metastasis in Papillary Thyroid Carcinoma with Maximum Lesion Diameter ≤1.0 cm.

Objective: Circulating tumor cell (CTC) has been used to assist in the diagnosis and progression assessment of solid tumors, but the relationship between preoperative CTCs levels and central lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTC) needs to be clarified.

Methods: Data on clinical features (age, gender, Hashimoto's thyroiditis, multifocal, maximum lesion diameter, invaded capsule, clinical stage, and status of lymph node metastasis) of PTC patients treated at our hospital between June 2021 and April 2023 were retrospectively collected. The relationship between the CTCs level and these clinical features was analyzed, especially the relationship between the CTCs level and CLNM.

The Association of Pretreatment Systemic Immune Inflammatory Response Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR) with Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma.

Objective: Immunoinflammatory response can participate in the development of cancer. To investigate the relationship between pretreatment systemic immune inflammatory response index (SII), systemic inflammatory response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and lymph node metastasis in patients with papillary thyroid carcinoma (PTC).

Methods: A retrospective analysis was performed on 547 PTC patients treated in Meizhou People's Hospital from January 2018 to December 2021.

Thyroglobulin Antibody (TgAb) Positive is an Independent Risk Factor for Lymph Node Metastasis in Patients with Differentiated Thyroid Carcinoma.

Objective: To investigate the relationship between lymph node metastasis and the clinicopathologic features of differentiated thyroid carcinoma (DTC) patients with thyroglobulin antibody (TgAb) positive and negative.

Methods: A total of 443 patients with DTC were included in this study. Clinicopathological data of the patients were collected, including tumor size, clinical stage, calcification, Hashimoto's thyroiditis, extra-membrane infiltration, V600E mutation status, and thyroid-related hormone and antibody levels.

Differences between reductive defluorination of perfluorooctanoic acid by chlorination, bromination, and iodization in the vacuum-ultraviolet/sulfite process.

The introduction of iodide (I) has broad perspectives on the decomposition of perfluorocarboxylates (PFCAs, CFCOO). However, the iodinated substances produced are highly toxic synthetic chemicals, hence, it is urgent to find a similar alternative with less toxicity. In this work, the defluorination of perfluorooctanoic acid (PFOA) by I, bromide (Br) and chlorine (Cl) was systematically compared in the VUV/sulfite process.

Efficient removal of per- and polyfluoroalkyl substances from biochar composites: Cyclic adsorption and spent regenerant degradation.

In order to solve the problem of efficient desorption of per- and polyfluoroalkyl substances (PFAS) and regeneration of adsorbents, a novel biochar composite was prepared based on the quaternary ammonium groups and hydrophobicity of sulfobetaine polymer, which can be used for the efficient removal of various PFASs and has great regeneration ability. Through adsorption, regeneration and degradation experiment, the comprehensive effect of the novel biochar composite on the whole process of removal of PFAS was systematically investigated. The results showed that the maximum adsorption capacity of PFOS, PFOA, PFBS, and PFBA reached 634 mg/g, 536 mg/g, 301 mg/g and 264 mg/g, respectively.

Younger Than 55 Years Old and V600E Mutation are Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinomas ≤1.0 cm but Not in >1.0 cm.

Background: Studies on the relationship between V600E mutation and the clinicopathologic features of papillary thyroid carcinoma (PTC), risk of lymph node metastasis in papillary thyroid microcarcinoma (PTMC) have shown inconsistent results.

Methods: In this retrospective analysis, clinicopathological data of the patients were collected, and molecular testing was done for V600E mutation. PTC patients are divided into PTC≤1.

Magnetic biochar promotes the risk of mobile genetic elements propagation in sludge anaerobic digestion.

Mobile genetic elements (MGEs) mediated horizontal gene transfer is the primary reason for the propagation of antibiotic resistance genes in environment. The behavior of MGEs under magnetic biochar pressure in sludge anaerobic digestion (AD) is still unknown. This study evaluated the effects of different dosage magnetic biochar on the MGEs in AD reactors.

Layered double hydroxides loaded sludge biochar composite for adsorptive removal of benzotriazole and Pb(II) from aqueous solution.

In this work, a novel sludge biochar/Zn-Al layered double hydroxide composite (SL) was synthesized in a facile co-precipitation method, and it was used to simultaneously remove benzotriazole (BTA) and lead ion (Pb(II)). Batch adsorption experiments demonstrated that composites with sludge content of 1.0 g (SL-1.

Exploring the role of Fe species from biochar-iron composites in the removal and long-term immobilization of SeO against competing oxyanions.

Carbothermal reduction is a convenient and cost-effective method to produce biochar (BC) supported iron-based nano-particles (INP) for oxyanion contaminants removal. However, considering the possible desorption of the target oxyanion during change of the surrounding environment, the detailed removal mechanisms remain unclear and the long-term efficiency of different INPs cannot be predicted. In this study, different BC/Fe composites were synthesized by controlling the pyrolysis temperatures (500-800 °C).

Microplastics in the coral reefs and their potential impacts on corals: A mini-review.

Plastic debris exists worldwide and research on microplastic pollution has gradually spread from the oceans to freshwater and terrestrial systems. Coral reefs not only serve as one of the most charismatic and biodiverse ecosystems on our planet, but also maintain the human harvesting of natural resources and livelihoods of hundreds of millions of people. However, the abundance and distribution characteristics of microplastics in coral reef systems receive little scientific attention.

Different adsorption behaviors and mechanisms of a novel amino-functionalized hydrothermal biochar for hexavalent chromium and pentavalent antimony.

A novel amino-functionalized hydrothermal biochar modified with nitric acid and nicotinamide (NMSH) was prepared and applied to remove heavy metal in different systems. The study of batch adsorption found that NMSH had different adsorption behaviors for Cr(VI) and Sb(V), and different concentrations of heavy metal ions exhibited different coadsorption behaviors in mixed system. NMSH had great anti-interference ability to coexisting inorganic ion and humic substance.

Sulfamic acid modified hydrochar derived from sawdust for removal of benzotriazole and Cu(II) from aqueous solution: Adsorption behavior and mechanism.

A novel hydrochar adsorbent derived from sawdust (SAHC) was prepared for highly efficient simultaneous removal of benzotriazole (BTA) and Cu(II) from aqueous solution. The prepared adsorbent was characterized by several methods such as SEM, FTIR, and XPS. Batch adsorption experiments showed that the maximum adsorption capacity of SAHC for BTA and Cu(II) was 159.

Magnetic nanoferromanganese oxides modified biochar derived from pine sawdust for adsorption of tetracycline hydrochloride.

In this study, a new type of composite material, namely modified biochar (MBC), was synthesized by loading the magnetic ferromanganese oxide nanoparticles on pine biochar. BET, SEM, and FTIR were employed to analyze the surface properties and pore structures of MBC. In addition, XRD was adopted to examine the crystal structure of MBC.

MiR-214 Regulates the Human Hair Follicle Stem Cell Proliferation and Differentiation by Targeting EZH2 and Wnt/β-Catenin Signaling Way .

miR-214 plays a major role in the self-renewal of skin tissue. However, whether miR-214 regulates the proliferation and differentiation of human hair follicle stem cells (HFSCs) is unknown. Primary HFSCs were isolated from human scalp skin tissue, cultured, and identified using flow cytometry.

Heavy metal leachability in soil amended with zeolite- or biochar-modified contaminated sediment.

In this work, reuse probability of heavy metal-contaminated sediment for land application was discussed using a 100-day column leaching assessment under the situation of simulated acid rain. For comparison, NaCl-modified zeolite and biochar were firstly studied for their adsorption capacity for Cu, Cd, and Pb in aqueous solution, and then their stabilizing effects on the three metals in sediment-soil mixture. Characteristic results indicated that NaCl-modified zeolite had properties more conducive to metal adsorption than biochar, including higher BET surface area and more negative surface charges.

Alginate-modified biochar derived from Ca(II)-impregnated biomass: Excellent anti-interference ability for Pb(II) removal.

A novel biochar modified with sodium alginate was prepared using Ca(II)-impregnated biomass, and used to remove metals from aqueous solutions. The maximum adsorption capacity for Pb(II) was estimated to be 1.225 mmol/g (253.

MicroRNA-16 inhibits the lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc by targeting .

Introduction: A variety of inflammatory mediators are produced by the degenerative human intervertebral disc (IVD) tissues spontaneously, suggesting their role in the development of intervertebral disc degeneration (IDD). Our present study was designed to investigate the regulatory effect of microRNA-16 (miR-16) on the lipopolysaccharide (LPS)-induced inflammatory response in nucleus pulposus (NP) cells of the IVD.

Material And Methods: NP cells were treated with LPS to induce inflammatory responses.