Exploring the Molecular Mechanisms and Biological Effects of CELF2 in the Development of Gastric Cancer.

Introduction: The CUGBP ELAV-like family member 2 (CELF2) gene is irregularly expressed in various types of cancer. However, the role of CELF2 in stomach adenocarcinoma (STAD) remains unclear. This study aims to elucidate its potential role in modulating tumor behavior in STAD, as well as its correlation with tumor-infiltrating immune cells.

Nitrate sensing and response in Plants: From calcium signaling to phytohormone regulation.

Plants need to acquire sufficient nitrogen (N) from the soil for their growth and development. Nitrate (NO) is the major source of N for plants in aerobic soils. In addition to its role as a nutrient, nitrate also acts as a signaling molecule to reprogram plant metabolism and trigger changes in plant architecture.

Clinical application of "purse-string suture" under endoscope in the treatment of refractory postoperative intestinal anastomotic fistula.

Background: Postoperative intestinal anastomotic fistula (PIAF) remains a challenging complication with suboptimal outcomes under conventional therapies. This study evaluates the safety and efficacy of endoscopic purse-string suturing (EPS) in managing refractory PIAF and identifies prognostic predictors.

Methods: A retrospective analysis of 55 patients with refractory PIAF treated via EPS (2015-2024) was conducted.

Effect of perioperative probiotic supplements on the short-term clinical outcomes of patients undergoing laparoscopic or robotic radical gastrectomy after neoadjuvant chemotherapy: Study protocol for a multicenter randomized controlled trial (GISSG2023 - 01 Study).

Background: Gastric cancer is a common malignant tumor, and radical gastrectomy can markedly improve the prognosis of gastric cancer patients. However, some patients are diagnosed with advanced gastric cancer before receiving any antitumor therapy and need to receive neoadjuvant chemotherapy (NACT). Previous studies have shown that NACT may cause gut barrier dysfunction and intestinal dysbacteriosis which may further lead to infections.

Spatiotemporal evolution and influencing factors of ecosystem services on Hainan Island from 1985 to 2022: Insights from long-term annual assessments and spatial econometric models.

Determining dynamic changes in ecosystem services (ESs) as well as their drivers is important for formulating effective ES management strategies and promoting regional sustainable development. However, long-term, continuous ES dynamic assessments and the spatial spillover effects of ESs have not been sufficiently addressed. To fill this gap, we conducted a comprehensive quantification of ESs on Hainan Island, specifically assessing habitat quality (HQ), carbon storage (CS), water yield (WY), soil conservation (SC), water purification (WP), and food production (FP) between 1985 and 2022.

Analysis of the efficacy of a prophylactic increasing blood pressure before the end of surgery to reduce postoperative bleeding after gastrectomy: a propensity score-matched analysis.

Objective: To investigate the efficacy of reducing post-gastrectomy hemorrhage by increasing blood pressure at the end of gastric surgery and to evaluate whether this clinical intervention affects the stability of patients' postoperative circulatory system.

Methods: A retrospective analysis was conducted on 499 patients who underwent radical gastrectomy under general anesthesia at our center between January 2023 and January 2024. After 1:1 propensity score matching, the experimental group comprised 157 patients whose operation cavities were examined after increasing blood pressure before the end of gastrectomy, while the control group included 157 patients whose operation cavities were examined using routine procedures without increasing blood pressure.

Dynamic changes and influential factors of blowouts in a desert artificial ecosystem at the southeastern margin of Tengger Desert in China.

The wind-blown sand protection system in the Shapotou section of the Baotou-Lanzhou Railway is a representative artificial ecosystem in a desert region. Over the past 70 years, this system has transformed mobile dunes into fixed dunes through vegetation succession, relying solely on natural rainfall without additional irrigation. However, ecosystem sustainability has been endangered by the emergence of numerous blowouts.

Mesocolic schwannoma mimicking gastrointestinal stromal tumor: A case report and review of literature.

Rationale: Schwannomas are common peripheral nerve tumors originating from Schwann cells, primarily occurring in the head and neck, limbs, and trunk. Schwannomas occurring in the mesocolon are rare and often have no specific manifestations. Abdominal schwannomas need to be differentiated from common abdominal tumors such as gastrointestinal stromal tumors.

Sensitive detection of Hg(II) on MoS/NiS based on interfacial engineering to accelerate the Ni/Ni cycle: Identification the role of atomic-level heterojunction-induced electron transfer in electroanalysis.

The valence change of transition metal ions in nanomaterials can highly enhance the electrochemical detection performance toward heavy metal ions (HMIs), and how to further promote the valence change calls enormous concerns in electroanalysis. In this work, an interfacial engineering that combing the MoS and NiS together to form the MoS/NiS complex is proposed. The density functional theory (DFT) results reveals that the novel atomic-level heterojunction between MoS and NiS will build an internal electric field (IEF), which leads to an enhanced conductivity and valence change behavior of Ni atoms in MoS/NiS complex, resulting in a superior detection performance.

Scinderin is a potential prognostic biomarker and correlated with immunological regulation: from pan-cancer analysis to liver hepatocellular carcinoma.

Aim: This study aimed to systematically dissect the role of Scinderin (SCIN) in tumorigenesis.

Methods: Bioinformatics techniques were employed based on cancer data from TCGA, ENCORI, HPA, GEPIA2, UALCAN, Kaplan-Meier plotter, TIMER, TISIDB, cBioPortal, HCCDB, GeneMANIA and LinkedOmics database. Experiments and were conducted to dissect the role of SCIN in liver hepatocellular carcinoma (LIHC).

Young patient with a giant gastric bronchogenic cyst: A case report and review of literature.

Background: Gastric bronchogenic cysts (BCs) are extremely rare cystic masses caused by abnormal development of the respiratory system during the embryonic period. Gastric bronchial cysts are rare lesions that were first reported in 1956; as of 2023, only 33 cases are available in the PubMed online database. BCs usually have no clinical symptoms in the early stage, and imaging findings also lack specificity.

Short- and long-term outcomes of single-port versus multiport laparoscopic radical gastrectomy for gastric cancer: a meta-analysis of propensity score-matched studies and randomized controlled trials.

Background: At present, there is no convincing evidence-based medical basis for the efficacy of single-port laparoscopic gastrectomy. To make a high-quality comparison of the short- and long-term outcomes of single-port laparoscopic gastrectomy versus multiport laparoscopic gastrectomy, we performed this meta-analysis, which only included propensity score-matched studies and randomized controlled trials comparing single-port laparoscopic gastrectomy with multiport laparoscopic gastrectomy for patients with gastric cancer.

Methods: Data were retrieved from the electronic databases PubMed, EMBASE, Medline, Cochrane Library, CNKI, Wanfang and VIP up to January 2023, and the data included the outcomes of treatment after single-port laparoscopic gastrectomy and multiport laparoscopic gastrectomy.

Long-Term outcomes of uncut roux-en-Y anastomosis in laparoscopic distal gastrectomy: A retrospective analysis.

Background: Uncut Roux-en-Y (U-RY) has been increasingly used in radical gastric cancer surgery, but it is still in the exploratory stage. There is insufficient evidence for its long-term efficacy.

Methods: From January 2012 to October 2017, a total of 280 patients diagnosed with gastric cancer were eventually included in this study.

Rare metastasis of gastric cancer to the axillary lymph node: A case report.

Lymph node metastasis of gastric cancer is more common, metastatic lymph nodes are often around the stomach, and metastasis is carried out in a certain order, but gastric cancer metastasis to axillary lymph nodes is very rare. Due to the small number of patients with this kind of metastasis, its clinical features and treatment are not very clear. We initially thought that the enlarged axillary lymph nodes were inflammatory lesions.

Laparoscopic Subtotal Gastrectomy and Sigmoidectomy Combined With Natural Orifice Specimen Extraction Surgery (NOSES) for Synchronous Gastric Cancer and Sigmoid Colon Cancer: A Case Report.

Background: Gastric cancer and colon cancer are rarely seen in clinic, but there are still related reports. For gastric cancer and simultaneous colon cancer, surgical resection is the main treatment. Traditional surgery requires an incision from xiphoid process to pubic symphysis.

Effects of Preoperative Pyloric Stenosis on Outcomes and Nutritional Status in 73 Patients Following Curative Gastrectomy for Gastric Cancer: A Retrospective Study from a Single Center.

BACKGROUND The aim of this study was to explore the potential impact of pyloric stenosis (PS) on the nutritional status, the incidence of postoperative complications, and the long-term prognosis of distal gastric cancer (GC) patients after curative resection. MATERIAL AND METHODS We retrospectively analyzed the data of 343 GC patients who underwent curative gastrectomy for gastric cancer between January 2010 and December 2013. All patients were divided into 2 groups according to the status of PS.

Is Pathologic Complete Response the Surrogate in Primary Gastric Angiosarcoma Undergoing Doxorubicin-Based Neoadjuvant Chemotherapy? A Case Report.

Introduction: Angiosarcoma is a malignant tumor with low incidence. Especially in the advanced tumors, there is still a lack of knowledge of evidence-based medicine.

Case Presentation: We report a case of a 55-year-old woman with abdominal pain of 2 months of duration, which had increased in severity for 2 weeks prior to the presentation.

Characteristics of Desertification and Short-Term Effectiveness of Differing Treatments on Shifting Sand Dune Stabilization in an Alpine Rangeland.

Rangeland desertification is one of the most serious problems threatening the ecological environment and socio-economic development on the eastern Qinghai-Tibet Plateau in China. To combat desertification and reduce its adverse effects, some strategies have been undertaken to stabilize the mobile sand dunes and restore the desertified land. In this study, rangeland desertification with a gradient degree of none, light, medium, severe and extreme was assessed, and short-term effectiveness of different treatments on stabilizing the shifting sand dunes was evaluated by monitoring selected vegetation and soil properties.

Tribological properties of nano-graphite as an additive in mixed oil-based titanium complex grease.

Nano-graphite was chosen as an additive to improve the tribological properties of titanium complex grease. The influence of the concentration of nano-graphite (N-G) with three average diameter sizes (2 μm, 3.5 μm, and 6 μm) on the tribological properties of titanium complex grease was researched.