Antiemetic drug fosaprepitant exerts anti-tumor effects against NSCLC by targeting FAK to inhibit AKT and JNK/c-Jun pathways.

Non-small cell lung cancer (NSCLC) is an aggressive malignancy with a poor prognosis. Abnormal expression of focal adhesion kinase (FAK) is closely linked to NSCLC progression, highlighting the need for effective FAK inhibitors in NSCLC treatment. In this study we conducted high-throughput virtual screening combined with cellular assays to identify potential FAK inhibitors for NSCLC treatment.

Lipoprotein(a) in neoplastic transformation.

Cardiovascular diseases and cancer are top global causes of death, sharing risk factors and treatment strategies. Although dyslipidemia is linked to both, its exact roles are unclear. Recent studies suggest a potential association between plasma lipoprotein(a) levels and cancer risk.

Association of Plasma Lipoprotein(a) With Major Adverse Cardiovascular Events in MASLD With or Without Advanced Liver Fibrosis.

Background And Aims: There is uncertainty regarding the role of plasma lipoprotein(a) [Lp(a)] in predicting cardiovascular events in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). We examined the association between plasma Lp(a) concentrations and major adverse cardiovascular events (MACE) in MASLD, stratified by the severity of liver fibrosis.

Methods: This study enrolled patients with MASLD from two centres.

Impact of intensive blood pressure control on cardiovascular and cognitive outcomes in patients with low muscle mass.

Background: Intensive blood pressure (BP) control in patients with low muscle mass on cardiovascular (CV) and cognitive outcomes remains unclear. Therefore, we aim to examine the impact of intensive BP control on CV and cognitive outcomes in patients with low muscle mass.

Methods: Data from the Systolic Blood Pressure Intervention Trial (SPRINT) were utilized to estimated muscle mass.

Triggering seesaw-like fluctuation of double plasmon peaks of Au@AuAg yolk-shell heterogeneous nanostructures for detection of Cu and Hg in drinking water.

Au@AuAg yolk-shell heterogeneous nanostructures (YSHNSs) with two major plasmonic absorption peaks of equal intensity are designed as multifunctional and multi-informational nanoprobes for detecting Cu and Hg, which are critical heavy metals threatening food safety and human health. By controlling the elemental distribution and morphological structure of Au@AuAg YSHNSs, two major absorption peaks can be accurately modulated. Since changing the thickness and composition ratio of Au@Ag alloy shell triggers a seesaw-like bidirectional conversion of two major absorption peaks, we establish the detection of Cu and Hg.

AgAu@Ag core-shell triangular nanonet jointed with composite SERS enhanced substrate for capturing and sensing urine biomarkers FGFR3 and NMP22.

Herein, we achieved ultrasensitive surface-enhanced Raman scattering (SERS) detection of bladder cancer (BC) urine biomarkers, nuclear matrix protein 22 (NMP22) and fibroblast growth factor receptor 3 (FGFR3) by preparing gold and silver core-shell triangular nanonets (AgAu@Ag TNNs) with porous triangular mesh structures. The tip effect of the triangular structure of AgAu@Ag TNNs and the plasma coupling of the mesh holes on its surface enabled an enhancement factor (EF) of 1.37 × 10.

Deformation mechanism and microstructure evolution of TC4 alloy during ultrasonic energy field-assisted deformation.

Ultrasonic vibration-assisted compression tests on TC4 alloy are performed at room temperature under various deformation and ultrasonic conditions. The influence of strain rate and Ultrasonic Energy Field (UEF) on plastic deformation behaviors and microstructure evolution is analyzed. The experimental results indicate that the flow stress exhibits a decreasing trend either with the decrease of strain rate or the application of UEF.

Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the Host and Microbiome.

Spinal cord injury (SCI) leads to severe neurological dysfunction with significant nutritional alterations. These alterations are closely associated with gut dysbiosis and neurogenic gut dysfunction after SCI, creating complex interactions that further exacerbate metabolic disturbances and impede neurological recovery. In the context of SCI, diet not only fulfills basic nutritional needs but also serves as an important therapeutic tool to modulate these interactions.

Incidence and efficacy of strategies for preventing hepatic encephalopathy following transjugular intrahepatic portosystemic shunt: A meta-analysis.

Background: Hepatic encephalopathy (HE) is a primary complication following transjugular intrahepatic portosystemic shunt (TIPS), but the utility of pharmacological prophylaxis for HE is unclear.

Aim: To assess the HE incidence post-TIPS across various groups and the prophylactic efficacies of various medications.

Methods: A thorough literature search was performed in PubMed, Web of Science, EMBASE, and the Cochrane Library databases from their inception to November 24, 2024, to collect data regarding HE incidence.

Comparison of outcomes of laparoscopic-assisted and total laparoscopic right hemicolectomy for right-sided colon cancer.

Background: Colon cancer is a significant health issue in China, with high incidence and mortality rates. Surgical resection remains the primary treatment, with the introduction of complete mesocolic excision in 2009 improving precision and outcomes. Laparoscopic techniques, including laparoscopic-assisted right hemicolectomy (LARH) and total laparoscopic right hemicolectomy (TLRH), have further advanced colon cancer treatment by reducing trauma, blood loss, and recovery time.

Broad-spectrum pathogenic bacteria SERS sensing with face-centered high-index facets Au CPNCs & microarray chips: A novel platform able to achieve dual-readout detection.

Non-specificity and inadequate quantitative capability are the primary challenges faced by the surface-enhanced Raman scattering (SERS) technique, especially when it comes to detecting bacteria in real samples. Herein, a novel face-centered Au Convex Polyhedral Nanocrystal (Au CPNC) with high-index facets and its assembly Au CPNCs microarray chip were designed and fabricated to address these challenges, within the process where 4-mercaptophenylboronic acid (4-MPBA) was utilized as a multifunctional element. The as-prepared Au CPNC possesses anisotropic raised edges enjoying tunable localized surface plasmon resonance modes for SERS enhancement.

Tafolecimab, a Third Monoclonal Antibody for PCSK9 as the Novel Lipid-Lowering Drug Around the World: A Narrative Review.

Tafolecimab, a fully human monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), represents a significant therapeutic advancement in the management of hypercholesterolemia and has been approved for use in the Chinese population. Elevated low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerotic cardiovascular disease, and traditional treatments often fall short due to challenges such as statin intolerance. Clinical trials have demonstrated that tafolecimab can effectively reduce LDL-C levels, achieving reductions of over 60% in many patients.

Ultrasensitive and multiplex SERS immunoassay for stroke subtype-specific biomarkers based on graphene oxide-supported nanofilms coated by roughened nanoboxes with extensive high-density hotspots.

Herein, we fabricate the graphene oxide-supported nanofilms coated by roughened nanoboxes (GO@AuAgRNB) for the ultrasensitive and simultaneous determination of multiple stroke subtype-specific biomarkers. Initially, Au-Ag roughened nanobox (AuAgRNB) with abundant coupling and tip hotspots is prepared by the partial surface passivation strategy. AuAgRNB is uniformly, densely and firmly assembled onto graphene oxide (GO) by metal-sulfur bonds, generating extensive high-density hotspots.

3D composite SERS substrate constructed by Au-Ag core-satellite NPs and polystyrene sphere for ultrasensitive ratiometric Raman detection of cotinine.

To enhance the efficacy of Surface-enhanced Raman spectroscopy (SERS), noble metal nanoparticles (NMNPs) can be organized onto three-dimensional (3D) hierarchical nanostructures. This study involved constructing a 3D solid SERS substrate by layering Au-Ag core-satellite nanoparticle monolayer films (MF) on a polystyrene sphere (PS) array, termed Au-Ag core-satellite NPs-MF-PS. Optimizing the PS size was essential to maximize SERS substrate activity, with the 500 nm PS providing the best SERS enhancement factor of 1.

Reservoir computing-based signal compensation for laser inter-satellite communications.

We introduce the reservoir computing (RC) concept into the laser processing unit for the scenario of the inter-satellite communication to mitigate the impacts from the multi-distortion sources, enabling significantly improving the quality of the coherent signals through the intelligent approach in outer space. We carry out the experimental investigations to quantify the impacts from the Sun radiation, the Doppler frequency shift and the vibration on the transmitted quadrature-phase-shift-keying (QPSK) signals, and perform the signal compensation through only one RC module at the receiver end. A maximum 5.

Atroposelective Diverse Remote -C-H Functionalization via Kinetic Resolution.

A diverse range of Pd(II)-catalyzed enantioselective C-H activation reactions have been developed to construct point, axial, and planar chirality. Despite the importance of chiral biaryl scaffolds in bioactive molecules and chiral ligands, atroposelective functionalization at the -position remains a significant challenge. Here, we realized a rare atroposelective remote -C-H functionalization with a chiral monoprotected amino acid (MPAA) ligand and a racemic transient norbornene mediator.

Gut microbiome composition in patients with liver cirrhosis with and without hepatic encephalopathy: A systematic review and meta-analysis.

Background: The gut microbiome is associated with hepatic encephalopathy (HE), but research results on the gut microbiome characteristics of patients with liver cirrhosis with and without HE are inconsistent.

Aim: To study the gut microbiota characteristics of patients with liver cirrhosis with and without HE.

Methods: We searched the PubMed, Web of Science, EMBASE, and Cochrane databases using two keywords, HE, and gut microbiome.

Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review.

Sleep is a fundamental phenomenon that helps maintain normal physiological processes. Conversely, sleep disorders, usually presented as insomnia, are a common public health problem that can lead to multiple pathophysiological changes in humans, including lipid metabolic abnormality. Interestingly, several previous studies have examined the potential relation of insomnia to metabolic syndrome and hyperlipidemia and found that insomnia was associated with elevated plasma cholesterol and triglyceride concentrations.

From PD-1/PD-L1 to tertiary lymphoid structures: Paving the way for precision immunotherapy in cholangiocarcinoma treatment.

Cholangiocarcinoma (CCA) is a highly malignant hepatobiliary tumor characterized by limited treatment options and poor prognosis. The recent rise of immunotherapy has significantly influenced research in this field. This study presents a bibliometric analysis of 416 articles retrieved from the WOSCC, Wan fang Data, CNKI and VIP databases, spanning contributions from 32 countries, 589 institutions and 3,200 authors.

Controlled growth of silver on gold triangular nanoprisms: Improved surface enhanced Raman scattering for ultrasensitive detection of cancer biomarker.

The precise design and synthesis of Au and Ag composite nanomaterials can provide them with richer plasmonic modes, resulting in enhanced optical properties. Here, a novel strategy was demonstrated to control the selective deposition of Ag at different positions of Au triangular nanoprisms (Au TNPs). 1,4-benzenedithiol (BDT) was selectively absorbed in different positions of Au TNPs which made Ag selectively deposited on Au TNPs.

Identification of nine mammal monosaccharides by solid-state nanopores.

Glycans, nucleic acids and proteins are three major classes of natural biopolymers. The extremely high diversity of isomerization makes structural elucidation of glycans the most challenging job among three classes. In the past few years, the single molecule sensing technique based on nanopores has achieved great success in sequencing of DNA.

Overexpression Facilitates the Progression and Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma.

Background: In the present day, hepatocellular carcinoma (HCC) remains a formidable threat to human health. Actin-related protein 10 () is related to tyrosine kinase inhibitor (TKI) resistance. A comprehensive analysis of in HCC will further our understanding of the molecular mechanisms underlying this resistance phenomenon, shedding light on potential therapeutic strategies for combating TKI resistance in HCC.