Stage-specific requirement for METTL3-dependent mA epitranscriptomic regulation during myogenesis.

The regulatory role of N-methyladenosine (mA) modification in skeletal muscle myogenesis and muscle homeostasis remains poorly characterized, particularly regarding the functional significance of methyltransferase-like 3 (METTL3), the catalytic subunit of the mA methyltransferase complex (MTC), in myogenic regulation. Through systematic investigation of mA epitranscriptomic remodeling during myogenesis, we demonstrate that METTL3-mediated mAs orchestrates myoblast fusion processes in both differentiation and regeneration contexts. Notably, we observed marked induction of Mettl3 expression post-injury, accompanied by substantial transcriptomic alterations in myogenesis-related pathways.

Novel zinc(II) complexes bearing N,N,N-tridentate pyrimidine ligands as antitumor agents: Synthesis, characterization and antitumor evaluation.

Herein, a series of Zn(II) complexes (1-4) with a six-coordinate octahedral configuration were successfully designed and synthesized using pyrimidine-pyridine derivatives HL-HL. The structures of complexes 1-4 were systematically characterized by H NMR, IR, UV-Vis, X-ray single-crystal diffraction and XRD. MTT assays using selected tumor cell lines (MCF-7, BGC-823, A549, and BEL-7402) demonstrated that complexes 1-4 exhibited superior anti-proliferative activity compared to their corresponding ligands HL-HL and the conventional chemotherapeutic agent cisplatin.

A highly sensitive and selective rectilinearly π-extended NIR fluorescent rhodamine probe for Cu detection in real food samples and fluorescence bioimaging in living cells and mice.

A novel near-infrared fluorescent probe (NRTB) was designed and synthesized to detect Cu. Its structure was characterized by H NMR, C NMR and ESI-HRMS. In addition, the fluorescence properties were improved by introducing an ethyl phenothiazine group into the rhodamine skeleton, resulting in a near-infrared (NIR) emission at 765 nm with a large Stokes shift of 165 nm.

Effect of Solvents on Electrogenerated Base-Driven Transfer Hydrogenation Reactions.

Transfer hydrogenation is a crucial technology for synthesizing fine chemicals and pharmaceuticals, offering improved safety and convenience over traditional hydrogen methods, although it typically requires external bases. While isopropanol is commonly used as a hydrogen source, methanol is superior but faces challenges due to its high dehydrogenation energy barrier, limiting its use under mild conditions. This study focuses on investigating the differences in the electrogenerated base-driven transfer hydrogenation of aromatic ketones in isopropanol and methanol solvents, using Mn(CO)₅Br and cyclohexanediamine derivatives as the catalyst.

Design, synthesis, anticancer activity and molecular docking of quinoline-based dihydrazone derivatives.

Based on the biologically active heterocycle quinoline, we successfully synthesized a series of quinoline-based dihydrazone derivatives (3a-3d). H NMR, C NMR, ESI-HRMS, IR, element analysis, UV/Vis spectroscopy and fluorescence spectroscopy were performed to comprehensively characterize their chemical structures, spectral properties and stability. Nitrosamine impurities were not detected in 3a-3d, and the systemic toxicological assessment indicated that the toxicity of 3a-3d was lower.

A near-infrared fluorescent probe for the detection of Cu in Chinese herbal medicine and imaging in living cells.

Copper is one of the common among the heavy metal pollution in Chinese herbal medicine (CHM). So, it is essential to develop rapid and accurate testing method to quantify the Cu content in CHM. Herein, we prepared a coordination-based near-infrared fluorescent probe (NRh6G-FA) by introducing a hemicyanine dye in rhodamine 6G scaffold.

Novel tetranuclear grid-like Zn(II) complexes derived from dihydrazone pyrimidine derivatives as antitumor agents.

Due to the antitumor properties, Zn(II) complexes have attracted more and more attention. Herein, three novel tetranuclear Zn(II) complexes 1-3 based on dihydrazone pyrimidine derivatives HL-HL were synthesized and characterized using IR spectroscopy, H NMR spectroscopy, single crystal X-ray diffraction analysis, XRD, TG and elemental analysis. Single crystal X-ray diffraction analysis revealed that 1-3 all displayed a [2 × 2] grid-like topology.

Nitrogen-doped mesoporous carbon supported CuSb for electroreduction of CO.

The construction of an efficient catalyst for electrocatalytic reduction of CO to high value-added fuels has received extensive attention. Herein, nitrogen-doped mesoporous carbon (NMC) was used to support CuSb to prepare a series of materials for electrocatalytic reduction of CO to CH. The catalytic activity of the composites was significantly improved compared with that of Cu/NMC.

Electrocatalytic carboxylation of halogenated compounds with mesoporous silver electrode materials.

Mesoporous silver materials are used as electrocatalysts for halogenated compounds. The mesoporous silver materials have uniform mesoporous size (8 nm), large specific surface area (12 m g), high pore volume (0.07 cm g), and a good 3D network structure of the metallic silver skeleton.

Electrochemically Promoted Asymmetric Transfer Hydrogenation of 2,2,2-Trifluoroacetophenone.

The study reported an electrochemically promoted asymmetric hydrogen transfer reaction of 2,2,2-trifluoroacetophenone with a chiral Ru complex. ()-α-(Trifluoromethyl) benzyl alcohol with a 96% yield and 94% ee could be obtained with only a 0.5 F mol charge amount at room temperature and normal pressure.

Brushable Lubricant-Infused Porous Coating with Enhanced Stability by One-Step Phase Separation.

Slippery lubricant-infused porous surface (SLIPS) is a promising solution to undesired adhesion. Unfortunately, the complicated fabrication process and limited coating area block its practical applications. Herein, we report a one-step strategy to fabricate polypropylene-based SLIPS coatings through thermally induced phase separation, in which the lubricant is infiltrated within a polymer network formed during cooling.

Atomically Dispersed Copper on N-Doped Carbon Nanosheets for Electrocatalytic Synthesis of Carbamates from CO as a C Source.

The synthesis of carbamates by electrocatalytic reduction of CO is an effective method to realize the utilization of CO resources. The development of high-performance electrocatalysts to complete this process more efficiently is of great significance to sustainable development. Owing to their unique structural characteristics, single-atom catalysts are expected to promote the reaction process more efficiently.

Ordered Mesoporous Carbon Embedded with Cu Nanoparticle Materials for Electrocatalytic Synthesis of Benzyl Methyl Carbonate from Benzyl Alcohol and Carbon Dioxide.

We prepared a series of ordered mesoporous carbons embedded with different contents of Cu nanoparticles (Cu/OMC-) and applied them to electrocatalytic synthesis of benzyl methyl carbonate. The materials were characterized by many measurements, which showed that Cu/OMC- materials maintain highly ordered mesoporous structures with high surface area and highly dispersed Cu nanoparticles. As expected, the materials exhibit good electrocatalytic performance.

Synthesis of Ag nanoparticles/ordered mesoporous carbon as a highly efficient catalyst for the electroreduction of benzyl bromide.

To develop efficient catalysts for the electroreduction of organic halides, a facile one-pot synthesis of Ag nanoparticles/ordered mesoporous carbon electrode materials the self-assembly of CHCOOAg and resol in the presence of triblock copolymer is proposed. The resultant electrode materials possess uniform mesopore sizes (3.3 nm) and pore volumes (∼0.

Silver encapsulated copper salen complex: efficient catalyst for electrocarboxylation of cinnamyl chloride with CO.

An active catalyst, [Cu]@Ag composite, was synthesized for the first time and used as a cathode for electrocarboxylation of cinnamyl chloride with CO. β,γ-Unsaturated carboxylic acids were obtained with excellent yield and moderate selectivity. Moreover, reasonable yields and selectivities of carboxylic acids were also achieved with several allylic halides and aryl halides.

One-Pot Synthesis of d-Phenylalanine-Functionalized Multiwalled Carbon Nanotubes: A Metal-Free Chiral Material for the Asymmetric Electroreduction of Aromatic Ketones.

A simple protocol to synthesize d-phenylalanine (d-PHE)-functionalized multiwalled carbon nanotubes (MWCNTs) via the one-pot method was established by grafting d-PHE onto MWCNTs to obtain d-PHE-MWCNTs under mild reaction conditions. The resulting d-PHE-MWCNTs were characterized in detail via spectroscopy and surface analysis. The electroreduction of 2,2,2-trifluoroacetophenone at the d-PHE-MWCNTs cathode afforded ( S)-α-(trifluoromethyl) benzyl alcohol whose yield was 65% and the enantiomeric excess was 40%.

One-pot synthesis of Ni nanoparticle/ordered mesoporous carbon composite electrode materials for electrocatalytic reduction of aromatic ketones.

A simple one-pot synthesis of Ni nanoparticle/ordered mesoporous carbon composite electrode materials is demonstrated for electrosynthesis for the first time. The obtained nanocomposites have uniform mesopore sizes (3.0-3.

Entrapment of a chiral cobalt complex within silver: a novel heterogeneous catalyst for asymmetric carboxylation of benzyl bromides with CO2.

A novel way to accommodate heterogeneous catalysis, CO2 fixation and asymmetric synthesis on one catalyst is reported. The [Co]@Ag composite was prepared for the first time and used for asymmetric carboxylation of benzyl bromides with CO2. All the procedures were performed under mild conditions.

Remarkable sensitivity of the electrochemical reduction of benzophenone to proton availability in ionic liquids.

The reduction of benzophenone was investigated in five different ionic liquids by using transient cyclic voltammetry, near steady-state voltammetry, and numerical simulation. Two reversible, well-resolved one-electron-reduction processes were observed in dry (≤20 ppm water, ca. 1 mM)) 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([Bmpyrd][NTf(2)]) and 1-butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide ([Bmpipd][NTf(2)]), which did not contain any readily available proton source.

Electrochemical study of dialcarb "distillable" room-temperature ionic liquids.

Electrode-dependent potential windows (see picture, GC=glassy carbon) are determined for five dialkylammonium carbamate (dialcarb) room-temperature ionic liquids in a systematic study of their physical and electrochemical properties. The viscosity and conductivity of the dialcarb ionic liquids, which are "distillable" at low temperature, are comparable to those of some conventional room-temperature ionic liquids. The physical and electrochemical properties of five "distillable" room-temperature ionic liquids from the dialcarb family (dialkylammonium carbamates formed from CO(2) and dialkyl amines) are systematically investigated.