Mouse monoclonal antibodies against toxins TcdA and TcdB target diverse epitopes for neutralization.

is a spore-forming, Gram-positive bacterium that can cause infections in subjects with weakened immune system or following antibiotic treatment. These infections may lead to pseudomembranous colitis and antibiotic-associated diarrhea in humans. As such, is a major cause of nosocomial illness worldwide.

Simultaneous generation of color-coded arteriography, venography, and dynamic angiography: methodology and clinical applications in stroke.

Cerebrovascular accident is a leading cause of death and disability. Early detection of cerebrovascular diseases is crucial for timely treatment. This study introduces a novel method for the simultaneous generation of color-coded arteriography, venography, and dynamic angiography derived from dynamic contrast-enhanced magnetic resonance angiography and computed tomography perfusion.

Long-Term Shape and Volume Retention of Acellular Dermal Matrix in Oncoplastic Breast-Conserving Surgery: A 2-Year Retrospective Study.

: To quantitatively assess the long-term volume stability of acellular dermal matrix (ADM) in oncoplastic breast-conserving surgery (OBCS) and analyze surgical and aesthetic outcomes. : This retrospective study examined 172 breast cancer patients who underwent OBCS with immediate ADM-based volume replacement (2020-2022). Patients received either diced ADM with sheet ADM ( = 102) or diced ADM with paste ADM (n = 70).

Rescue angioplasty and stenting in refractory acute vertebrobasilar occlusion after mechanical thrombectomy: A single center experience.

Objective: Acute vertebrobasilar occlusion can led to a fatal outcome, but lack of established procedures poses many difficulties in its management. Although mechanical thrombectomy (MT) has shown positive outcomes recently, high reocclusion rate remains a hurdle. This study is to share experience and to review technical challenges of rescue angioplasty and/or stenting (RAS) for refractory occlusions after MT in posterior circulation ischemic stroke (PCIS).

Applications and Effectiveness of 3D Printing in Various Ankle Surgeries: A Narrative Review.

Background: Technological advancements have made three-dimensional printing prevalent in orthopedic surgery. It facilitates the production of customized implants and tailored patient instruments, enhancing surgical planning and results. This review focuses on the uses and effectiveness of patient-specific products manufactured using three-dimensional printing in ankle surgery.

Dual intra-articular injections of corticosteroid and hyaluronic acid versus single corticosteroid injection for ankle osteoarthritis: a randomized comparative trial.

Background: Intra-articular corticosteroid injection is commonly used for pain relief in ankle osteoarthritis (OA). The effects of corticosteroids (CS) are short-lived, whereas hyaluronic acid (HA) have longer-lasting effects. The objective was to compare the efficacy of dual injections of CS and HA to CS alone.

Multiphase CTA vs. MRA collateral map for predicting functional outcomes after acute ischemic stroke.

Purpose: To compare the prognostic abilities of multiphase CT angiography (mCTA) and multiphase MR angiography (MRA) collateral map in acute anterior circulation ischemic stroke.

Methods: This secondary analysis of a prospective observational study included data from participants with acute ischemic stroke due to steno-occlusion of the internal carotid artery and/or middle cerebral artery within 8 h of symptom onset between January 1, 2016, and March 31, 2021. The intermethod agreement of the collateral scores (CSs) from mCTA and the collateral perfusion scores (CPSs) from the MRA collateral map was analyzed.

Arthroscopy assistance in the surgical management of distal radius fractures does not result in superior radiological and functional outcomes: A systematic review and meta-analysis of randomized controlled trials.

Purpose: To evaluate the efficacy of assistant arthroscopy in the surgical treatment of distal radius fractures (DRFs) by the functional and radiological outcomes between the arthroscopic and control groups.

Methods: We searched the PubMed, Embase, Web of Science, and Cochrane Library databases for studies that compared the clinical outcomes of patients who underwent surgery with or without adjuvant arthroscopy. After screening the studies, we identified six randomized controlled trials.

Clinical feasibility of deep learning-driven magnetic resonance angiography collateral map in acute anterior circulation ischemic stroke.

To validate the clinical feasibility of deep learning-driven magnetic resonance angiography (DL-driven MRA) collateral map in acute ischemic stroke. We employed a 3D multitask regression and ordinal regression deep neural network, called as 3D-MROD-Net, to generate DL-driven MRA collateral maps. Two raters graded the collateral perfusion scores of both conventional and DL-driven MRA collateral maps and measured the grading time.

The CT collateral map: collateral perfusion estimation and baseline lesion assessment after acute anterior circulation ischemic stroke.

Purpose: To investigate the clinical feasibility of a CT collateral map compared with an MRA collateral map, focusing on collateral perfusion (CP) estimation and baseline lesion assessment in acute ischemic stroke (AIS).

Materials And Methods: This retrospective analysis used selected data from a prospectively collected database. We generated CT collateral maps derived from CT perfusion, encompassing images of arterial, capillary, early venous (CMEV), late venous, and delay phases.

Natural course of the acute unruptured intracranial vertebral artery dissections which show pearl-and-string sign.

Introduction: Ruptured vertebral artery dissections frequently exhibit pearl-and-string signs, a characteristic also observed in many unruptured dissections. This study examines the natural course of 50 unruptured acute vertebral artery dissections presenting with pearl-and-string signs and compares them to 10 ruptured dissections of the same morphological pattern.

Methods: We reviewed 633 radiology reports of head and neck imaging studies that included the keyword 'dissection'.

Target Gene-Based Association Study of High Mobility Group Box Protein 1 in Intracranial Aneurysms in Koreans.

We investigated the effect of high mobility group box 1 (HMGB1) on intracranial aneurysms (IAs) by analyzing single-nucleotide polymorphisms (SNPs) based on genome-wide association study (GWAS) data. HMGB1 mRNA and protein expression levels in plasma were also analyzed. : This study was a comprehensive analysis of a GWAS dataset, including 250 patients with IAs and 294 controls.

Joint Preservation Surgery Using Supramalleolar Osteotomy Combined with Posterior Tibial Tendon Release and Lateral Ligament Augmentation in Advanced Varus Ankle Arthritis.

: Recent studies utilizing weight-bearing computed tomography have identified abnormal internal rotation of the talus in advanced varus ankle arthritis (VAA) with a large talar tilt (TT), influenced by the posterior tibial tendon (PTT). This study aimed to evaluate the clinical and radiographic results of supramalleolar osteotomy (SMO) combined with PTT release and lateral ligament augmentation for VAA with a large TT. : From January 2015 to September 2018, 15 patients with VAA and a large TT (greater than 5°) underwent SMO combined with PTT release.

Mechanical Thrombectomy for Hyperacute Vertebrobasilar Ischemic Stroke via Nondominant Vertebral Artery : Clinical Experience and Considerations.

Objective: The dominant vertebral artery (VA) approach is primarily considered in mechanical thrombectomy (MT) for acute occlusion of the vertebrobasilar (VB) artery. As accessing the dominant artery is sometimes difficult, we present our experience treating acute VB stroke via a nondominant VA approach through a comparison with the dominant VA approach.

Methods: Among 2785 patients diagnosed with hyperacute ischemic stroke between January 2014 and December 2022, 50 patients with VB ischemic stroke underwent recanalization therapy through either dominant, nondominant, or bilateral VA approach.

Hyaluronic acid/polyphenol sunscreens with broad-spectrum UV protection properties from tannic acid and quercetin.

Currently, commercial sunscreens cause a number of biotoxicity and environmental issues, making it imperative to develop biocompatible alternatives. In this study, we aimed to develop an alternative sunscreen from two ecofriendly and biocompatible natural polyphenolic compounds, tannic acid (TA) and quercetin (Que). The sunscreen was prepared through a simple process using an oil-in-water emulsion as the medium and hyaluronic acid (HA) as the base polymer to improve biocompatibility.

Prognostic value of collateral perfusion estimation by arterial spin labeling for acute anterior circulation ischemic stroke.

Purpose: This study aimed to verify the value of arterial spin labeling (ASL) collateral perfusion estimation for predicting functional outcomes in acute anterior circulation ischemic stroke.

Methods: This secondary analysis of an ongoing prospective observational study included data from participants with acute ischemic stroke due to steno-occlusion of the internal carotid artery and/or the middle cerebral artery within 8 h of symptom onset. We compared the collateral map, which is a 5-phase collateral imaging derived from dynamic contrast-enhanced magnetic resonance angiography, and ASL to validate the ASL collateral perfusion estimation.

The collateral map: prediction of lesion growth and penumbra after acute anterior circulation ischemic stroke.

Objectives: This study evaluated the collateral map's ability to predict lesion growth and penumbra after acute anterior circulation ischemic strokes.

Methods: This was a retrospective analysis of selected data from a prospectively collected database. The lesion growth ratio was the ratio of the follow-up lesion volume to the baseline lesion volume on diffusion-weighted imaging (DWI).

The Efficacy of Platelet-Rich Plasma Augmentation in Microfracture Surgery Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis.

The appropriate surgical management of osteochondral lesions of the talus (OLT) remains a challenge for foot and ankle surgeons. Currently, microfracture (MF) is the first-line operative treatment for small osteochondral lesions. However, the fibrous cartilage regenerated after MF is mechanically inferior to hyaline cartilage regeneration and is susceptible to deterioration over time.

Impact of Collateral Circulation on Futile Endovascular Thrombectomy in Acute Anterior Circulation Ischemic Stroke.

Objective: Collateral circulation is associated with the differential treatment effect of endovascular thrombectomy (EVT) in acute ischemic stroke. We aimed to verify the ability of the collateral map to predict futile EVT in patients with acute anterior circulation ischemic stroke.

Methods: This secondary analysis of a prospective observational study included data from participants underwent EVT for acute ischemic stroke due to occlusion of the internal carotid artery and/or the middle cerebral artery within 8 hours of symptom onset.

Study on Sustentaculum Tali Fragment Constancy in Intraarticular Calcaneus Fracture.

Objectives: To establish reproducible measurements of the sustentaculum tali (ST) fragment regarding fracture classification and patient-related factors.

Design: Retrospective.

Setting: Trauma center, University Hospital.

Bone-Marrow-Derived Mesenchymal Stem Cells Attenuate Behavioral and Cognitive Dysfunction after Subarachnoid Hemorrhage via HMGB1-RAGE Axis Mediation.

We evaluated the therapeutic effects of bone-marrow-derived mesenchymal stem cells (BMSCs) on behavioral and cognitive function in a mouse model of mild subarachnoid hemorrhage (SAH) and explored the underlying mechanisms in conjunction with the HMGB1-RAGE axis. The SAH models were generated in a total of 126 male C57BL/6J mice via endovascular perforation and evaluated 24 h and 72 h after the intravenous administration of BMSCs (3 × 10 cells). The BMSCs were administered once, at 3 h, or twice, at 3 h and 48 h after the model induction.