OLSIA: Open Lumbar Spine Image Analysis - A 3D Slicer Extension for Segmentation, Grading, and Intervertebral Disc Height Index with Multi-Dataset Validation.

Study Design: Retrospective and cross-sectional study.

Objective: The study aims to develop an open software for lumbar spine image analysis enabling no-code approach to lumbar spine segmentation, grading, and intervertebral disc height index (DHI) calculations with robust evaluation of the application on six external datasets from diverse geographical regions.

Summary Of Data: The datasets used include NFBC1966 (Finland), HKDDC (Hong Kong), TwinsUK (UK), CETIR (Spain), NCSD (Hungary), SPIDER (Netherlands), and Mendeley (global).

Osteoblast-CD4 CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age-Related Bone Loss.

The dynamic production and clearance of senescent osteoblasts affects bone homeostasis and health. However, the relationship between senescent osteoblasts and the immune system remains unclear. Here, a landscape of the interaction between immune cells and osteoblasts through spatial analysis of the bone microenvironment is presented.

Chatbot-delivered structured psychological intervention (SPI-Bot) for teenagers with adolescent idiopathic scoliosis in Hong Kong: protocol for a pilot randomised controlled trial.

Introduction: Adolescent idiopathic scoliosis (AIS) often imposes a significant psychological burden on teenagers. Cognitive and behavioural strategies have demonstrated the potential to alleviate these challenges. Chatbots, with their real-time interaction capabilities, provide a promising and accessible approach to delivering psychological interventions for young people.

Comparisons of Preferences Toward EQ-5D-Y-3L Health States Between Adult Own and Child Perspectives.

Objectives: The international valuation protocol for EQ-5D-Y-3L recommends elicitation of utilities using adults' preference for a hypothetical 10-year-old child. Published studies have reported preference difference in adults when valuing for a child and valuing for themselves. This study aimed to obtain EQ-5D-Y-3L preferences in Hong Kong and understand the preference difference between the adult own perspective and the child perspective.

The perioperative complications of vertebral body tethering : prevalence and predictive factors.

Aims: There is little information in the orthopaedic literature about the rate of perioperative complications of vertebral body tethering (VBT), in the surgical management of patients with adolescent idiopathic scoliosis. The aim of this study was to determine the rate of these complications and to investigate the corresponding predictive factors.

Methods: This was a prospective single-centre study involving all patients who underwent VBT between February 2019 and October 2024.

AO Spine Clinical Practice Recommendations for the Surgical Management of Degenerative Spondylolisthesis: When to Decompress Alone and When to Fuse.

Study DesignLiterature review.ObjectiveTo provide a concise review of outcomes of decompression and fusion (D + F) vs decompression (D) alone for degenerative lumbar spondylolisthesis (DLS).Methods6 articles were selected, including 3 randomized clinical trials (RCT), 2 meta-analyses, and 1 radiographic cohort study.

Factors contributing to bracing success in juvenile idiopathic scoliosis and current limitations : a systematic review and meta-analysis.

Aims: There is a general lack of guidelines on nonoperative treatment in juvenile idiopathic scoliosis (JIS). This review aims to explore factors determining bracing success in JIS and to identify limitations in current literature.

Methods: A literature search was conducted according to the PRISMA 2020 guidelines.

Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear-Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes.

Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as pain and disability) after considering confounders (spinal phenotypes, fear-avoidance beliefs [FABs] and insomnia). This study examined: (1) differences in confounders and LMM characteristics between individuals with and without CLBP; and (2) associations between confounders, LMM parameters, and clinical outcomes in the CLBP group alone.

Methods: Participants (CLBP = 70 and asymptomatic people = 67) underwent lumbar magnetic resonance imaging.

Current status of Asian joint registries: a review.

A comprehensive overview of current Asian joint arthroplasty registries, highlighting their strengths and weaknesses and providing a case for establishing registries nationwide, is given. Pertinent information required for the future establishment and improvement of Asian joint arthroplasty registries is given. Six registries in Asia were identified, with three, Indian Joint Registry, Japanese Orthopaedic Association National Registry and Pakistan National Joint Registry having developed official websites and published annual reports.

Psychometric Validation and Responsiveness of the Cross-culturally Adapted Traditional Chinese Version of the Early-onset Scoliosis Self-report Questionnaire (EOSQ-SELF).

Background: Patients with early-onset scoliosis (EOS) can experience compromised health-related quality of life (HRQoL). EOSQ-SELF was developed to assess HRQoL directly from patients, yet its responsiveness remains unclear. We aimed to evaluate the psychometric properties and responsiveness of the cross-culturally adapted traditional Chinese version of EOSQ-SELF.

Prevalence and Risk Factors for Postoperative Neurological Complications in Spinal Deformity Surgery: A Systematic Review and Proportional Meta-Analysis.

Objective: To investigate the incidence of postoperative neurological complications among patients who underwent spinal deformity surgery and to determine the significant risk factors for postoperative neurological complications.

Methods: Six databases PubMed, Web of Science, Scopus, MEDLINE, Embase, and Cochrane Library have been searched to identify observational studies from inception until January 2025. Inclusion criteria were patients aged ≥10 years with postoperative neurological complications after spinal deformity surgery.

Exploring the potential relationships between idiopathic scoliosis and various multifactorial diseases: a systematic scoping review.

Background: Although the etiology of adolescent idiopathic scoliosis (AIS) remains largely elusive, it is widely recognized as a multifactorial condition shaped by both genetic predispositions and environmental influences. This review seeks to explore the intricate relationships between idiopathic scoliosis and its associated comorbidities, with the goal of advancing our understanding of this multifaceted disorder.

Methods: Primary studies involving human subjects diagnosed with idiopathic scoliosis and presenting comorbid conditions were included.

Conservative and newer drug treatment for degenerative cervical myelopathy.

Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults worldwide. Conservative treatments, such as physical therapy, activity modification, cervical traction, and the use of cervical collars, have been employed primarily for symptomatic relief in mild cases or for patients deemed unfit for surgery. Advances in our understanding of the molecular pathways involved in neuroinflammation and neuronal injury in DCM have spurred the development of newer pharmacological treatments aimed at neuroprotection and inflammation control.

How Accurate Are Fulcrum Bending Radiographs in Estimating Postoperative Outcomes in Adolescent Idiopathic Scoliosis? A Systematic Review and Meta-analysis.

Background: Fulcrum bending radiographs can be used to assess coronal flexibility in patients with adolescent idiopathic scoliosis (AIS) to estimate postoperative correction. To obtain fulcrum bending radiographs, patients are passively bent over a radiolucent fulcrum at the apex of the curve. Available studies have disagreed about the accuracy in estimating postoperative correction, although these studies differed in terms of patients' baseline characteristics as well as other methods.

Lateral view fulcrum bending radiographs predict postoperative hypokyphosis after selective thoracic fusion in adolescent idiopathic scoliosis.

Study Design: A retrospective observational study.

Purpose: To identify the surgical and preoperative risk factors on fulcrum bending radiographs for postoperative hypokyphosis in patients with Lenke 1 adolescent idiopathic scoliosis (AIS).

Overview Of Literature: AIS is associated with thoracic hypokyphosis.

Factors influencing the adoption of innovation in spine surgery: An international survey of AO spine network.

Introduction: Knowledge translation from research to clinical practice can often be challenging, and practice modification patterns among surgeons may stem from a variety of sources, including personal experience, peer influence, ongoing education, and evolving research findings.

Research Question: This study aimed to investigate the adoption patterns amongst surgeons for newer innovations and to analyse the factors affecting the implementation of the same in clinical practice. We used the adoption of osteobiologics as a case example.

EUFormer: Learning Driven 3D Spine Deformity Assessment with Orthogonal Optical Images.

In clinical settings, the screening, diagnosis, and monitoring of adolescent idiopathic scoliosis (AIS) typically involve physical or radiographic examinations. However, physical examinations are subjective, while radiographic examinations expose patients to harmful radiation. Consequently, we propose a pipeline that can accurately determine scoliosis severity.

Denosumab Enhances Antitumor Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells.

Denosumab, a RANK ligand inhibitor, is primarily used to prevent osteoclastogenesis in the treatment of conditions such as osteoporosis, bone metastasis, and giant cell tumor of bone (GCTB). RANK ligand also plays an important role in immunity by activating NF-κB and its target genes, including the osteopontin-coding gene SPP1 (also known as OPN), which is linked to CXCL9:SPP1 macrophage polarization and prognosis. In this study, we explored an additional role of denosumab in enhancing antitumor immunity in patients.

Sensitivity of intraoperative electrophysiological monitoring for scoliosis correction in identifying postoperative neurological deficits: a retrospective chart review of the Scoliosis Research Society morbidity and mortality database.

Background: Surgical intervention is the ultimate treatment for scoliosis, but iatrogenic spinal cord injury is one of the major concerns. Although intraoperative electrophysiological monitoring can aid in detecting and reducing postoperative neurological complications, its use is still controversial.

Methods: A retrospective chart review of 6,577 scoliotic patients who underwent surgery for curve correction with a reported complication was conducted.

Global Practices and Preferences in the Use of Osteobiologics for Anterior Cervical Discectomy and Fusion: A Cross-Sectional Study.

Study DesignCross-sectional study.ObjectivesTo assess global practices and preferences in the use of osteobiologics for anterior cervical discectomy and fusion (ACDF) and identify factors influencing the choice of specific osteobiologics.MethodsAn online survey developed by AO Spine was distributed to spine surgeons worldwide.

Relationships of PedsQL 4.0 generic core scales with other validated HRQoL instruments in braced idiopathic scoliosis patients: An age and curve severity-specific analysis.

This study aims to investigate if the addition of PedsQL 4.0 generic core scales (PedsQL) with other validated instruments in day-to-day clinical context is feasible. Patients with idiopathic scoliosis who were undergoing brace treatment and aged 8-18 were asked to fill in the PedsQL 4.

The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study.

Importance: Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field.

Objective: To develop an evidence-informed, consensus-guided, adaptable digital health competencies framework for the design and development of digital health curricula in medical institutions globally.

Evidence Review: A core group was assembled to oversee the development of the Digital Health Competencies in Medical Education (DECODE) framework.