Cholesterol-modulating effects of Korean red ginseng (KRG) targeting PCSK9 in hyperlipidemia.

Hyperlipidemia represents a major global health concern, closely linked to cardiovascular disease (CVD) and metabolic syndrome. Effective regulation of blood lipid and cholesterol (CHO) is essential for preventing and managing this condition. Korean red ginseng (KRG), a traditional medicinal plant, exhibits diverse pharmacological properties, including antihyperlipidemic, immune-enhancing, anti-fatigue, and antistress effects.

Enhancing metabolic syndrome prediction using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography data and machine learning: a comprehensive analysis.

Background: Metabolic syndrome (MetS) is a complex health concern and the incidence of MetS is rising, even among the general population, necessitating effective identification and management strategies. This study aimed to determine if a predictive model using variables from fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and machine learning (ML) could enhance the prediction of MetS.

Methods: We retrospectively reviewed the medical records of 1,250 adults who underwent FDG PET/CT for cancer screening between 2014 and 2020.

Advanced human FcRn knock-in mice for pharmacokinetic profiling of therapeutic antibodies.

IgG-based therapeutic antibodies are increasingly adopted for diverse human diseases, such as cancer and autoimmune disorders displaying remarkable therapeutic performance. A key factor in their success lies in the extended half-life of IgG molecules, which is regulated by the pH-dependent interaction between IgG and neonatal Fc receptor (FcRn). This interaction prevents lysosomal degradation of IgG.

Relationship Between Affiliate Stigma, Stress and Perceived Quality of Life Among Parents of Children With Down Syndrome.

Background: To examine the relationship between affiliate stigma, stress and perceived quality of life amongst parents of children with Down syndrome (DS).

Method: Seventy-eight parents of children with DS completed the Affiliate Stigma Scale (ASS), Caregiver Burden Inventory (CBI) and Care-related Quality of Life (CarerQol) scales.

Results: Pearson correlations revealed that parents did not feel stigmatised for having a child with DS (M = 30.

Phosphatase regulation in cell division: With emphasis on PP2A-B56.

Protein phosphatase 2A-B56 (PP2A-B56) is a key regulator of mitosis, playing an essential role in maintaining chromosomal stability and ensuring the fidelity of cell division. As a component of the PP2A holoenzyme, the B56 regulatory subunit confers substrate specificity, primarily through interactions with the conserved LxxIxE motif on target proteins. This review highlights the molecular mechanisms by which PP2A-B56 regulates key processes in cell division, including chromosome cohesion and condensation, kinetochore-microtubule attachment, spindle assembly checkpoint silencing, and activation of the anaphase-promoting complex/cyclosome.

Comparison of the maximum standardized uptake value and magnetic resonance imaging characteristics between temporomandibular joint osteoarthrosis and osteoarthritis.

Osteoarthritis (OAI) and osteoarthrosis (OAO) are subsets of degenerative joint diseases affecting the temporomandibular joint (TMJ), distinguished by the presence of joint pain. However, clinical diagnosis based on pain alone is challenging. This study aimed to differentiate OAI from OAO using imaging modalities, including single-photon emission computed tomography (SPECT-CT) and magnetic resonance imaging (MRI).

Speech-language Telepractice Services During the COVID-19 Lockdown: Perspectives from Parents in Malaysia.

This study explores Malaysian parents' perspectives on speech-language pathology (SLP) telepractice services during the COVID-19 lockdown. SLP services for families living in rural areas of Malaysia can be challenging, due to travel issues associated with distance, transportation costs, scheduling conflicts, and for patients with restricted physical mobility. To investigate the efficacy of SLP services in Malaysia during the COVID-19 lockdown, 70 parents' preferences and perspectives were explored via a survey of demographics, service engagement, and views on telepractice.

EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice.

Introduction: The etoposide-induced 2.4 kb transcript (EI24) plays a crucial role in autophagy, facilitating the clearance of damaged proteins and organelles to maintain cellular homeostasis. While autophagy is widely recognized for its beneficial effects on healthy aging, the effects of EI24 overexpression remain unclear.

Patch clamp recordings of action potentials from pyramidal neuron in hippocampus CA1 under focused ultrasound neurostimulation with MEMS self-focusing acoustic transducer.

This study aims to investigate the modulatory effects of focused ultrasound (FUS) on neuronal activity at the single-cell level, using whole-cell patch clamp recordings in hippocampal slices.A self-focused acoustic transducer (SFAT) was designed and fabricated on a 127m-thick translucent lead zirconate titanate substrate to allow infrared light transmission for visualizing neurons during patch clamp experiments. The SFAT operates at 18.

Do soil health indicators predict carbon and nitrogen functional stability under drought and heat?

Healthier soils are often assumed to retain function better under climate stress. However, links between common soil health indicators and soil functional resilience to stress are elusive. Our goal was to link soil health status with stress response by quantifying the multifunctional carbon (C) and nitrogen (N) cycling response of soils under different management (forest, conventional, or organic) to drought or combined drought and heat stress.

Combined immune checkpoint inhibitors and ablative radiotherapy in metastatic cancers: a meta-analysis of prospective clinical trials.

Objective: To pool data from prospective clinical trials investigating combined stereotactic ablative radiotherapy (SABR) with immune checkpoint inhibitors (ICI) in patients with metastatic cancers.

Methods And Analysis: PubMed, Scopus and EMBASE were queried for full-length articles of prospective clinical trials involving patients with metastatic solid tumours. Random-effects meta-analysis was performed with the Knapp-Hartung method.

Mixed binary supporting electrolyte approach for enhanced synaptic functionality in one-shot integrable electropolymerized synaptic transistors.

The limitations of traditional von Neumann architectures have driven interest in organic mixed ionic-electronic conductors (OMIECs) for integrating memory and computation. Organic electrochemical synaptic transistors (OESTs) are particularly promising for emulating biological synaptic behaviors because they offer low power consumption, flexibility, and scalability. One-shot integrable electropolymerization (OSIEP) has emerged as a promising approach for fabricating OESTs owing to its simplicity and integrative capabilities.

Comparative effectiveness and safety of colistin-based versus high-dose ampicillin/sulbactam-based combination therapy for nosocomial pneumonia caused by carbapenem-resistant .

Differences exist between Infectious Diseases Society of America guidance and European Society of Clinical Microbiology and Infectious Diseases guidelines on treating pneumonia caused by carbapenem-resistant (CRAB). This study compared the outcomes of colistin-based and high-dose ampicillin/sulbactam-based combination therapies in patients with CRAB nosocomial pneumonia. A retrospective cohort study was conducted at a university-affiliated hospital in South Korea.

Downregulation of O-GlcNAcylation enhances etoposide-induced p53-mediated apoptosis in HepG2 human liver cancer cells.

Etoposide, an anticancer drug that inhibits topoisomerase II, is commonly used in combination chemotherapy. However, the impact of O-GlcNAcylation regulation on etoposide's anticancer effects has rarely been investigated. This study evaluated the effect of etoposide on cellular O-GlcNAcylation and whether modulating this process enhances etoposide-induced apoptosis.

Role of Arabidopsis monomeric E3 ubiquitin ligases in the ABA signaling pathway.

Abscisic acid (ABA) is a key phytohormone that regulates multiple biological processes in plants, including seed germination, seedling growth, and abiotic stress response. ABA enhances drought tolerance by promoting stomatal closure, thereby improving crop productivity under unfavorable stress conditions. Extensive research efforts have focused on understanding ABA signaling more clearly for its potential application in agriculture.

Corrigendum: Recent advances of additively manufactured noninvasive kinematic biosensors.

[This corrects the article DOI: 10.3389/fbioe.2023.

Berberine Enhances Neuroregeneration in a Rat Model of Peroneal Nerve Transection Injury: An Animal Study.

Background: Berberine has therapeutic potential in central nervous system disorders, however, few studies have investigated the effect of berberine on axonal regeneration in PNS injury models. Thus, this study aims to assess the effects of berberine on axonal regeneration in a peroneal nerve transection rat model.

Methods: Sprague-Dawley rats were divided into two groups: group B, berberine (20 mg/kg) intraperitoneal injection after peroneal nerve transection; and group C, normal saline injection as a control.

Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesis.

Until now, Hippo pathway-mediated nucleocytoplasmic translocation has been considered the primary mechanism by which yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) transcriptional coactivators regulate cell proliferation and differentiation via transcriptional enhanced associate domain (TEAD)-mediated target gene expression. In this study, however, we found that TAZ, but not YAP, is associated with the Golgi apparatus in macrophages activated via Toll-like receptor ligands during the resolution phase of inflammation. Golgi-associated TAZ enhanced vesicle trafficking and secretion of proinflammatory cytokines in M1 macrophage independent of the Hippo pathway.

Diagnostic criteria for temporomandibular joint osteoarthritis using standardized uptake value in single-photon emission computed tomography-computed tomography.

This study aimed to investigate the cutoff values of standardized uptake values (SUVs) and their accuracy using single-photon emission computed tomography-computed tomography (SPECT-CT) for temporomandibular joint (TMJ) osteoarthritis (OA) based on magnetic resonance imaging (MRI) and clinical examination. We included 106 joints of 53 patients with TMJ OA. SUVmax and SUVpeak of each TMJ was measured.

Latent profile analysis of spinal deep muscle strength and physical fitness in elite Taekwondo athletes.

In Taekwondo, core stability and physical fitness are vital for performance, with spinal deep muscles playing a key role. This study explored the relationship between spinal deep muscle strength and physical fitness in 104 adolescent Taekwondo athletes, using a cross-sectional design in a laboratory setting. Participants were classified into groups based on spinal muscle strength at various angles, measured with a Centaur 3D machine.

Ethical Dilemmas Among Oncology Nurses in China: Cross-Sectional Study.

Background: Effective communication about cancer prognosis is imperative for enhancing the quality of end-of-life care and improving patient well-being. This practice is sensitive and is heavily influenced by cultural values, beliefs, and norms, which can lead to ethical dilemmas. Despite their significance, ethical challenges in nursing related to prognosis communication are understudied in China.

Association of Striatal Dopamine Depletion and Brain Metabolism Changes With Motor and Cognitive Deficits in Patients With Parkinson Disease.

Background And Objectives: Parkinson disease (PD) shows degeneration of dopaminergic neurons in the substantia nigra and characteristic changes in brain metabolism. However, how they correlated and affect motor and cognitive dysfunction in PD has not yet been well elucidated.

Methods: In this single-site cross-sectional study, we enrolled patients with PD who underwent -(3-[F]fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (F-FP-CIT) PET, F-fluorodeoxyglucose (F-FDG) PET, the Movement Disorder Society-sponsored Unified PD Rating Scale examination, and detailed neuropsychological testing.

Anti-Melanogenic Effects of a Polysaccharide Isolated from Sporophyll Extracts.

is a temperate brown alga known to exert free radical-scavenging and anti-inflammatory effects. In this study, we investigated the skin-whitening effects of sporophyll extracts (UPEs) in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 melanoma cells. The crude polysaccharide fraction (UPF) was obtained via ethanol precipitation.

A transparent p-type semiconductor designed a polarizability-enhanced strongly correlated insulator oxide matrix.

Electron-transporting transparent conducting oxides (TCOs) are a commercial reality, however, hole-transporting counterparts are far more challenging because of limited material design. Here, we propose a strategy for enhancing the hole conductivity without deteriorating the band gap () and workfunction () by Cu incorporation in a strongly correlated NiWO insulator. The optimal Cu-doped NiWO (CuNiWO) exhibits a resistivity reduction of ∼10 times NiWO as well as band-like charge transport with the hole mobility approaching 7 cm V s at 200 K, a deep of 5.