Significance of Inflammation Marker of Radionecrosis in Laryngopharynx Cancer Treated With Radiation.

Objective: Radiotherapy is an effective treatment modality for head and neck cancer; however, it is associated with various side effects. One of the most devastating complications in the laryngopharyngeal region is radionecrosis, which presents with various signs and symptoms and can significantly impair patients' quality of life. This study aimed to identify factors related to the occurrence of radionecrosis and to evaluate treatment outcomes based on clinical experience.

Using natural nitrites from Angelica keiskei and high hydrostatic pressure treatment for producing high-quality cured pork loin with significant nitrous pigment formation.

High-quality cured meat can be produced by the combined application of natural curing agents (NCAs) and processing technology. This study investigates the synergistic effect of an NCA (fermented Angelica keiskei extract) and high hydrostatic pressure (HHP) treatment on the physicochemical properties of cured meat. The nitrites and phenolic compounds in the NCA facilitate cured meat color formation while minimizing the content of residual nitrites and lipid oxidation.

Transcriptom Analysis of Fruit Body Treated with Gamma Radiation on Mycelium.

Fungi have a high resistance to gamma radiation. Previous studies elucidating the resistance mechanisms to gamma radiation have mainly been conducted using yeast model organisms, but molecular-level mechanisms targeting fungi have been largely unexplored. In order to examine the response of to gamma radiation, we conducted comparative transcriptome analysis using RNA-Seq on fruit bodies derived from mycelium exposed with 200 Gray of gamma radiation.

Enhancing the Predictions of Cytomegalovirus Infection in Severe Ulcerative Colitis Using a Deep Learning Ensemble Model: Development and Validation Study.

Background: Cytomegalovirus (CMV) reactivation in patients with severe ulcerative colitis (UC) leads to worse outcomes; yet, early detection remains challenging due to the reliance on time-intensive biopsy procedures.

Objective: This study explores the use of deep learning to differentiate CMV from severe UC through endoscopic imaging, offering a potential noninvasive diagnostic tool.

Methods: We analyzed 86 endoscopic images using an ensemble of deep learning models, including DenseNet (Densely Connected Convolutional Network) 121 pretrained on ImageNet.

Ultrasonographic findings as a prognostic factor in parotid cancer.

ObjectiveRecent advancements in high-resolution ultrasonography (US) have established it as a critical tool for evaluating parotid lesions. However, the lack of standardized diagnostic criteria limits the utility of US in determining malignancy. This study investigates the potential role of US as a prognostic factor in parotid cancer.

Effect of ice pack volume on quality properties of pork meat in a delivery box model.

This study investigated the effects of varying ice pack volume on temperature control and the quality of pork in a delivery box in a 30 °C environment for 72 h. Temperature fluctuations, microbial growth, pH, volatile basic nitrogen (VBN), thiobarbituric acid reactive substances (TBARS), and metabolic alterations were analyzed with the use of 500, 1,000, 1,500, and 2,000 g of ice. Increasing the ice volume delayed temperature rises and phase transitions, prolonging cooling, and reduced microbial proliferation, with 1,500 g of ice maintaining microbiological safety for 48 h.

Effect of ultra-high pressure treatment on the physico-chemical properties of emulsified meat analogs.

The aim of this study was to evaluate the effects of ultra-high pressure (UHP) treatment on the physicochemical and structural properties of emulsified alternative meat products. Emulsified samples were treated at pressures of 100-500 MPa and their pH, color, moisture contents, WHC (water holding capacity), viscosity, emulsion stability and textural properties were analyzed. The results showed that UHP significantly improved pH, lightness and redness in all treatment groups.

Clinical Features and Prognostic Insights in Sinonasal Sarcomas: A 76-Case Single-Institution Experience.

Objective: This study analyzed the clinical characteristics, treatment outcomes, and prognostic factors of sinonasal sarcomas through a single-institution experience involving 76 cases over 27 years.

Methods: A retrospective review was conducted on 76 patients diagnosed with sinonasal sarcoma at a tertiary medical center from 1995 to 2022. Data collected included demographic information, tumor characteristics, and treatment modalities.

Mapping immunotherapy potential: spatial transcriptomics in the unraveling of tumor-immune microenvironments in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) often exhibits poor response rates to immune checkpoint inhibitor (ICI) therapies, largely owing to the intricate composition and spatial organization of immune cells within the tumor-immune microenvironment (TIME). The diversity of immune cell populations, their spatial relationships, and dynamic interactions significantly influence the immunosuppressive nature of the TIME, thereby limiting the efficacy of immunotherapy. To address these challenges and enhance the therapeutic potential of ICIs in HNSCC, a comprehensive analysis of the TIME is essential.

SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent inflammation and epithelial cell dysfunction, but the underlying molecular mechanisms remain poorly understood. Here we show that dysregulated lipid metabolism and increased lipid peroxidation in nasal polyp epithelial cells contribute to the pathogenesis of CRSwNP. Integrated analysis of bulk and single-cell RNA sequencing data reveals upregulation of SLC27A2/FATP2 in nasal polyp epithelium, which correlates with increased lipid peroxidation.

General and central obesity were significantly correlated with blood lead level in non-smoking, general population aged 30-50, without hypertension.

Introduction: To investigate the association between obesity and blood lead level (BLL) in the general population after controlled for menopause, blood pressure, calcium, and smoking; we assessed the relationship between BMI, WC (Waist Circumference), and blood lead levels in the non-smoking middle-aged subjects without hypertension among 2018 KNHANES. All data were recategorized into S1 (BMI<25 kg/m & WC<90 cm), S2 (intermediate), and S3 (BMI>25 kg/m & WC>90 cm).

Methods: We made the log transformation of blood lead levels to bring them closer to a normal distribution.

Anti-Melanogenic Effects of a Polysaccharide Isolated from Sporophyll Extracts.

is a temperate brown alga known to exert free radical-scavenging and anti-inflammatory effects. In this study, we investigated the skin-whitening effects of sporophyll extracts (UPEs) in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 melanoma cells. The crude polysaccharide fraction (UPF) was obtained via ethanol precipitation.

Thermodynamic phase control of Cu-Sn alloy electrocatalysts for selective CO reduction.

In the electrochemical CO reduction reaction (CORR), Cu alloy electrocatalysts can control the CORR selectivity by modulating the intermediate binding energy. Here, we report the thermodynamic-based Cu-Sn bimetallic phase control in heterogeneous catalysts for selective CO conversion. Starting from the thermodynamic understanding about Cu-Sn bimetallic compounds, we established the specific processing window for Cu-Sn bimetallic phase control.

Quality Characteristics of Meat Analogs through the Incorporation of Textured Vegetable Protein and Larvae in the Presence of Transglutaminase.

Alternative protein sources with greater nutritional value and a lower environmental footprint have recently attracted interest in the production of meat substitutes. However, it is required that these alternatives mimic the texture and structure of meat. This study investigated varying ratios of textured vegetable proteins (TVP) to larvae (brown mealworm; TM) with the addition of transglutaminase (TG) to determine the quality characteristics of these emulsions.

The Antioxidant Activity of Sporophyll Extract Obtained Using Ultrasonication: A Focus on Crude Polysaccharide Extraction Using Ethanol Precipitation.

, a marine biological resource from which antioxidants such as polysaccharides can be obtained, is primarily distributed in the coastal areas of East Asia. Reactive oxygen species (ROS) are essential for physiological processes; however, excess ROS levels in the body result in cellular oxidative damage. Several extraction methods exist; however, factors such as long extraction times and high temperatures degrade polysaccharides.

Identification of the primary ciliary proteins IFT38 and IFT144 to enhance serum-mediated YAP activation and cell proliferation.

Primary cilia are essential cellular antennae that transmit external signals into intracellular responses. These sensory organelles perform crucial tasks in triggering intracellular signaling pathways, including those initiated by G protein-coupled receptors (GPCRs). Given the involvement of GPCRs in serum-induced signaling, we investigated the contribution of ciliary proteins in mitogen perception and cell proliferation.

The experience of device failure after cochlear implantation.

Background: The present study describes the treatment of patients at a tertiary institution who experienced device failure after Cochlear Implantation (CI), as well as identifying prodromic symptoms that could assist in the timely identification and management of device failure.

Study Design: Retrospective database review (January 2000-May 2017).

Setting: Single tertiary hospital.

Changes in Nasal Tip Aesthetics Over Time Following Asian Tip Plasty.

Objectives: This study aimed to evaluate the sequential postoperative changes in tip aesthetics, by evaluating the aesthetic performance of the septal extension graft with or without tip grafting.

Methods: A total of 62 patients who underwent rhinoplasty with tip plasty were included. Using a three-dimensional scanner, we measured anthropometric aesthetic features of the nasal tip, including tip height, tip width, nasolabial angle, and columellar lobular angle.

Revision Rhinoplasty Using Glued Diced Costal Cartilage Shaped With Mold for Management of Complicated Silicone Rhinoplasty.

Background: Complicated silicone nose is a common clinical problem. Selection of replacement material for revision dorsal augmentation is a challenging task.

Objectives: The authors presented their experience in the use of molded glued diced cartilage graft (GDCG) for revision rhinoplasty in patients who had complicated silicone augmentation.

Early Ambulation to Prevent Delirium After Long-Time Head and Neck Cancer Surgery.

Objective: Postoperative delirium is known to have various adverse effects on head and neck surgery patients. This study was designed to identify possible risk factors of delirium following long periods of head and neck cancer surgery and to help prevent postoperative delirium.

Methods: We enrolled 197 patients who underwent long-time (>6 h) head and neck surgery at the Asan Medical Center from January 2017 to December 2018 in this study.

Investigation of Flow Changes in Intracranial Vascular Disease Models Constructed with MRA Images.

This study aimed to develop a magnetic resonance imaging (MRI)-compatible flow delivery system and individualized models of circle of Willis (CoW), which include 50% and 100% blockage in internal carotid artery (ICA50 and ICA100), and 100% blockage in vertebral artery (VA100). Images were obtained using 3D time-of-flight and phase-contrast magnetic resonance angiography (MRA) sequences, and changes in velocity and flow direction at CoW models were analyzed. For the ICA50 and VA100 models, the flow was similar to that of the normal model.