Comparison of the effects of metformin and empagliflozin on cardiac function in heart failure with preserved ejection fraction mice.

Purpose: Recent evidence suggests that empagliflozin (EMPA) and metformin (MET) may improve prognosis in heart failure with preserved ejection fraction (HFpEF) patients. This study aims to compare their effects on cardiac structure and function in HFpEF.

Methods: Male C57BL/6J mice were fed a high-fat diet with L-NAME for 8 weeks to induce HFpEF, followed by 4 weeks of MET or EMPA treatment.

Integrative physiological, transcriptomic and metabolomic analysis reveals how the roots of two ornamental Hydrangea macrophylla cultivars cope with lead (Pb) toxicity.

Lead (Pb) soil contamination has caused serious ecological and environmental issues. Hydrangea macrophylla is a potential Pb-contaminated soil remediation plant, however, their Pb stress defense mechanism is largely unknown. Here, the physiology, transcriptomic and metabolome of two H.

Intelligent Recognition Using Ultralight Multifunctional Nano-Layered Carbon Aerogel Sensors with Human-Like Tactile Perception.

Humans can perceive our complex world through multi-sensory fusion. Under limited visual conditions, people can sense a variety of tactile signals to identify objects accurately and rapidly. However, replicating this unique capability in robots remains a significant challenge.

A high-quality genome provides new insights into evolutionary history and pigment biosynthetic pathways in the Caryophyllales.

is a perennial ornamental shrub that is highly regarded in ornamental horticulture around the world. However, the absence of genome data limits our understanding of the pathways involved in bract coloration and breeding. Here, we report a chromosome-level assembly of the giga-genome of 'Mrs Butt', a cultivar thought to be the origin of many other cultivars.

Delphinieae flowers originated from the rewiring of interactions between duplicated and diversified floral organ identity and symmetry genes.

Species of the tribe Delphinieae (Ranunculaceae) have long been the focus of morphological, ecological, and evolutionary studies due to their highly specialized, nearly zygomorphic (bilaterally symmetrical) spiral flowers with nested petal and sepal spurs and reduced petals. The mechanisms underlying the development and evolution of Delphinieae flowers, however, remain unclear. Here, by conducting extensive phylogenetic, comparative transcriptomic, expression, and functional studies, we clarified the evolutionary histories, expression patterns, and functions of floral organ identity and symmetry genes in Delphinieae.

Association Between Circulating Cell-Free DNA Level at Admission and the Risk of Heart Failure Incidence in Acute Myocardial Infarction Patients.

Plasma cell-free DNA (cfDNA) was elevated in patients with acute myocardial infarction (AMI) or heart failure (HF). However, whether cfDNA could serve as a predictor for risk of HF after AMI remains unknown. In this study, we conducted a pilot prospective cohort study in which 98 AMI patients were enrolled from a single center to assess the association between cfDNA levels at admission and risk of HF in an AMI population.

An Enhanced Intrusion Detection Model Based on Improved kNN in WSNs.

Aiming at the intrusion detection problem of the wireless sensor network (WSN), considering the combined characteristics of the wireless sensor network, we consider setting up a corresponding intrusion detection system on the edge side through edge computing. An intrusion detection system (IDS), as a proactive network security protection technology, provides an effective defense system for the WSN. In this paper, we propose a WSN intelligent intrusion detection model, through the introduction of the k-Nearest Neighbor algorithm (kNN) in machine learning and the introduction of the arithmetic optimization algorithm (AOA) in evolutionary calculation, to form an edge intelligence framework that specifically performs the intrusion detection when the WSN encounters a DoS attack.

An optimized machine learning technology scheme and its application in fault detection in wireless sensor networks.

Aiming at the problem of fault detection in data collection in wireless sensor networks, this paper combines evolutionary computing and machine learning to propose a productive technical solution. We choose the classical particle swarm optimization (PSO) and improve it, including the introduction of a biological population model to control the population size, and the addition of a parallel mechanism for further tuning. The proposed RS-PPSO algorithm was successfully used to optimize the initial weights and biases of back propagation neural network (BPNN), shortening the training time and raising the prediction accuracy.

Conjuncted photo-thermoelectric effect in ZnO-graphene nanocomposite foam for self-powered simultaneous temperature and light sensing.

The self-powered sensors are more and more important in current society. However, detecting both light and temperature signals simultaneously without energy waste and signal interference is still a challenge. Here, we report a ZnO/graphene nanocomposite foam-based self-powered sensor, which can realize the simultaneous detection of light and temperature by using the conjuncted photo-thermoelectric effect in ZnO-graphene nanocomposite foam sensor.

The morphology, molecular development and ecological function of pseudonectaries on Nigella damascena (Ranunculaceae) petals.

Pseudonectaries, or false nectaries, the glistening structures that resemble nectaries or nectar droplets but do not secrete nectar, show considerable diversity and play important roles in plant-animal interactions. The morphological nature, optical features, molecular underpinnings and ecological functions of pseudonectaries, however, remain largely unclear. Here, we show that pseudonectaries of Nigella damascena (Ranunculaceae) are tiny, regional protrusions covered by tightly arranged, non-secretory polygonal epidermal cells with flat, smooth and reflective surface, and are clearly visible even under ultraviolet light and bee vision.

Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma.

Background: The kinesin superfamily protein member KIF21B plays an important role in regulating mitotic progression; however, the function and mechanisms of KIF21B in cancer, particularly in hepatocellular carcinoma (HCC), are unknown.

Aim: To explore the role of KIF21B in hepatocellular carcinoma and its effect on prognosis after hepatectomy.

Methods: First, data on the differential expression of KIF21B in patients with HCC from The Cancer Genome Atlas database was analyzed.

Primary intestinal extranodal natural killer/T-cell lymphoma, nasal type: A case report.

Background: Primary intestinal extranodal natural killer/T-cell lymphoma, nasal type (PI-ENKTCL) is a rare non-Hodgkin's lymphoma (NHL) subtype, and its prognosis is extremely poor. Clinical characteristics of the disease are not obvious and easily misdiagnosed. In this case report, we describe a patient with PI-ENKTCL who presented with intermittent hematochezia.

Surface modification of PS microtiter plate with chitosan oligosaccharides by Co irradiation.

By Co-γ irradiation method, the Chitosan-oligosaccharide (COS) was grafted onto the inner surface of the polystyrene (PS) microtiter, which was soaked with COS solution before the irradiation. To evaluated the effect of COS concentration on the properties of the PS microtiter, FTIR, XPS, AFM, Contact angle tester and enzyme-linked analyser was used to measure the surface properties and BSA adsorption of PS-COS plates. The results shows that, with the increase of COS concentration, the contact angle clearly decreased at the dose of 12kGy.

[Molecular identification and sequence analysis of broad bean wilt virus 2 isolates from atractylodes macrocephala Koidz].

To identity the pathogen that causes the mosaic and yellowing symptoms on Atractylodes macrocephala Koidz in Jiangxian, Shanxi province, biological inoculation, sequence-independent amplification (SIA),RT-PCR and other identification methods were used. The results showed that the chlorotic and necrosis symptoms occurred in the indicator plant Chenopodium quinoa after it was infected with the pathogen,and the same symptoms appeared after the reinoculation of healthy Atractylodes macrocephala Koidz; this reflected that the disease was likely to be caused by a virus. The results of SIA and sequencing showed that Broad bean wilt virus 2 (BBWV2) was present in severely mosaic Atractylodes macrocephala Koidz leaves.