Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

Background: Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis.

Methods: In this single-center trial, we randomly assigned 60 patients with acute pancreatitis in the intensive care unit (ICU) to receive 5 % albumin and crystalloid solution or crystalloid solution alone. Patients in the albumin group received 30 g of 5 % albumin daily within the first 3 days of admission.

Exploring the Molecular Functions and Immune Relevance of Macrophage-Associated Genes in Atherosclerosis.

Atherosclerosis is a common and significant cardiovascular condition that frequently goes undiagnosed by conventional diagnostic and treatment techniques until it reaches a more advanced stage. This challenge impedes the capacity to apply early detection and intervention measures. As a result, the creation of innovative and more accurate biomarkers is critically important.

Corrigendum: Biomarkers of GH deficiency identified in untreated and GH-treated Pit-1 mutant mice.

[This corrects the article DOI: 10.3389/fendo.2025.

A metal-free synthesis of phosphoramidates via I-catalyzed oxidative coupling of anilines/amines with H-phosphonates.

An efficient and environmentally benign protocol for synthesizing valuable and structurally diverse phosphoramidates via the sodium iodide (NaI)-catalyzed oxidative cross-coupling of various H-phosphonates with both aromatic and aliphatic amines. This new method utilizes HO (30% aq.) as a green oxidant, ethyl acetate (EA) as a renewable, low-toxic solvent, and inexpensive, readily available NaI (10 mol%) as the sole catalyst, circumventing the need for toxic reagents, transition metal catalysts, and special equipment.

Biomacromolecule-mediated targeted protein degradation: an emerging strategy for cancer therapy.

Conventional cancer chemotherapeutics have long been confronted by significant challenges such as adverse effects and drug resistance. A target protein degradation technology, proteolysis targeting chimeras (PROTACs), emerges as a novel modality but with pharmacokinetic issues and toxicity limitations. In order to overcome limited permeability of PROTACs and minimize their on-target off-tumor toxicity in healthy tissues, various conjugates with biomacromolecules (antibodies or aptamers) have been engineered.

The role of lipophagy in liver cancer: mechanisms and targeted therapeutic interventions.

Liver cancer, the advanced stage of various chronic liver diseases, has garnered attention due to its high incidence and insidious progression. Lipid droplets (LDs), unique lipid storage organelles in hepatocytes, play a pivotal role in lipid metabolism. Lipophagy, a selective autophagy process initially identified in hepatocytes, regulates lipid homeostasis by selectively degrading LDs.

The prognostic role of Geriatric 8 in patients with cancer: a meta-analysis and systematic review.

Objective: Previous studies have reported conflicting results regarding the association between the Geriatric 8 (G-8) geriatric screening tool and prognosis in patients with cancer. This meta-analysis aimed to evaluate the prognostic value of the G-8 score in patients with cancer.

Methods: PubMed, Cochrane Library, Embase, and Medline databases were searched to identify trials exploring the association between G-8 score and prognosis in patients with cancer.

Advances in Catalytic Host Cathodes for Aqueous Metal (Zn, Cu, Fe)-Ion Batteries.

Aqueous batteries with conversion mechanisms show promise for large-scale energy storage due to the inherent safety, cost-effectiveness, high energy density, and eco-friendly advantages. However, redox species migration and sluggish kinetics critically impede the further development of aqueous-conversion batteries. The integration of catalytically active sites into host cathode materials has been proposed as an effective solution to these challenges, with notable advancements in research.

Biomarkers of GH deficiency identified in untreated and GH-treated Pit-1 mutant mice.

Background: Growth Hormone Deficiency (GHD) is marked by insufficient growth hormone (GH) production, leading to disruptions in growth and metabolism. Its diagnosis is challenging due to the lack of sensitive, specific tests. To address this, we used a novel mouse model with a POU1F1 (Pit-1) gene mutation (K216E).

Porous VC@VSe heterostructure with built-in electric field as catalytic host materials for high-performance aqueous Cu-Se batteries.

Conversion-type aqueous copper-selenium (Cu-Se) batteries have gained considerable attention due to their high theoretical capacity, safety and environmental friendliness. However, the multi-electron intermediate conversion reaction of selenium cathode generally possesses sluggish kinetics, which seriously impedes the further development of Cu-Se batteries. Herein, the porous VC@VSe heterostructure (P-VC@VSe) with built-in electric field (BIEF) were successfully synthesized by the sacrificial template method and in situ selenization strategy, which were used as the selenium host materials for aqueous Cu-Se batteries to effectively enhance the selenium conversion reaction kinetics.

Corrigendum: CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network.

[This corrects the article DOI: 10.3389/fmolb.2024.

Sacituzumab tirumotecan in advanced non-small-cell lung cancer with or without EGFR mutations: phase 1/2 and phase 2 trials.

Trophoblast cell-surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC) is a promising anticancer agent that has shown remarkable efficacy in several malignancies. However, in lung cancer, two phase 3 trials on TROP2-ADCs in unselected patients with advanced non-small-cell lung cancer (NSCLC) have both failed. Sacituzumab tirumotecan (sac-TMT) is a novel TROP2-directed ADC.

Diallyl Trisulfide, an Active Substance from Garlic, Inhibits Female Oviposition by Decreasing the Expression of the Gene, which is Highly Expressed in the Spermathecal Gland of (Oliver).

Diallyl trisulfide (DAT) effectively inhibits the fecundity of . () was most highly expressed in the spermathecal gland of female moths and was significantly decreased after DAT fumigation. However, the function of OCT in insect reproduction has been rarely reported.

First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial.

Programmed cell death protein-1 (PD-1) inhibitors plus chemotherapy have been the standard of care in the first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma; however, the survival benefits are modest in patients with low programmed death ligand 1 (PD-L1) expression. Here we investigated the efficacy and safety of cadonilimab (PD-1/cytotoxic T lymphocyte antigen-4 (CTLA-4) bispecific antibody) plus chemotherapy as first-line treatment in G/GEJ adenocarcinoma. The prespecified interim analysis is reported here.

CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network.

Introduction: The critical role of circular RNAs as non-coding RNAs in glioma has been extensively investigated. Therefore, we aimed to explore the role and potential molecular mechanisms of circRNA-mind bomb homolog 1 (circMIB1) in gliomas.

Methods: RNA sequencing was used to analyze the expression profiles of circRNAs in glioma tissues and normal brain tissues.

Pharmacokinetics of infigratinib and its active metabolites in Chinese patients with advanced gastric cancer harboring FGFR2 gene amplification.

Infigratinib, an FGFR1-3 selective oral tyrosine kinase inhibitor, has shown clinical activity in cancers with FGFR alterations. The pharmacokinetics (PK) of infigratinib and its major metabolites have been characterized in global populations. This study examined the PK profile of infigratinib and its metabolites in Chinese patients.

In vivo glycerol metabolism in patients with glycerol kinase deficiency.

Glycerol kinase deficiency (GKD) is an X-linked recessive disorder due to () gene mutations resulting in hyperglycerolermia, hyperglyceroluria, and "pseudohypertriglyceridemia." In vivo glycerol metabolism has not been assessed in GKD. A 62-year-old man with suspected GKD and his extended family underwent whole exome sequencing and fasting blood work with two modes of lipid measurements: (1) standard lipase-based methodology and (2) nuclear magnetic resonance (NMR).

Recombinant Bacillus subtilis expressing functional peptide and its effect on blunt snout bream (Megalobrama amblycephala) in two state of stress.

This study was conducted to investigate the effects of recombinant Bacillus subtilis CM66-P4' (secreting P4, which related to previous research in this laboratory) on the antioxidant capacity and immune function of blunt snout bream (Megalobrama amblycephala) through in vitro and in vivo experiment. The culture experiment was divided into 3 groups, including control group (CG, with no additional bacteria), original bacteria group (OBG, with 2 × 10 CFU/kg Bacillus subtilis CM66) and recombinant bacteria group (RBG, with 2 × 10 CFU/kg Bacillus subtilis CM66-P4'). After 8 weeks of feeding, a part of the fish were subjected to fishing stress, and the rest were subjected to starvation stress test.

The Global Trend of Drug Resistant Sites in Influenza A Virus Neuraminidase Protein from 2011 to 2020.

Influenza A virus (IAV) causes highly contagious respiratory disease worldwide, so prevention and control of IAV is extremely important. However, overuse of neuraminidase inhibitor (NAI) drugs leads to drug resistance. To explore the up-to-date geographical distribution and evolution of drug-resistant mutations (DRMs) in the NA protein of IAV, 81,492 near full-length NA sequences downloaded from NCBI and GISAID databases, including 34,481 H1N1 and 46,622 H3N2, were processed and analyzed.

Multisite DNA methylation alterations of peripheral blood mononuclear cells serve as novel biomarkers for the diagnosis of AIS/stage I lung adenocarcinoma: a multicenter cohort study.

Background: Early diagnosis remains an obstacle for improving the outcome of lung adenocarcinoma (LUAD). DNA methylation changes in peripheral blood mononuclear cells (PBMCs) could reflect an immune response to tumorigenesis, providing the theoretical basis for early cancer diagnosis based on immune cell profiling.

Methods: This multi-center study evaluated the DNA methylation patterns based on PBMCs samples from 1115 individuals at nine medical centers.

Pretreatment Computed Tomography-Defined Sarcopenia, Treatment-Associated Muscle Loss, and Survival in Patients With Cervical Cancer: A Systematic Review and Meta-Analysis.

Context: Sarcopenia has been identified as a potential predictor of poor prognosis in various types of cancer. However, the impact of pretreatment sarcopenia and the reduction of skeletal muscle mass during treatment on survival outcomes of patients with cervical cancer is still not well understood.

Objective: This meta-analysis was conducted to investigate the impact of pretreatment sarcopenia and treatment-associated muscle loss on survival outcomes in patients with cervical cancer.

Improved air kerma determination in the radiation field of the X-ray tube used in medical imaging systems, considering the type and thickness of the filter.

In diagnostic radiology, the air kerma is an essential parameter. Radiologists consider the air kerma, when calculating organ doses and dangers to patients. The intensity of the radiation beam is represented by the air kerma, which is the value of energy wasted by a photon as it travels through air.

Application of microbubble air flotation to harvest Microcystis sp. from agriculture wastewater: The regulation and mechanisms.

The harvesting of microalgae is the main bottleneck of its large-scale biomass production, and seeking an efficient, green, and low-cost microalgae harvesting technology is one of the urgent problems to be solved. Microbubble air flotation has been proven to be an effective measure, but the mechanisms of microbubbles-algal cell attachment are still unclear. In this study, microbubble air flotation was used as a harvesting method for Microcystis cultured in agricultural wastewater.