Publications by authors named "Hui-Min Bu"
Article Synopsis
- - An investigation was conducted on the therapeutic effects of Tanshinone IIA for treating pulmonary fibrosis (PF) using a mouse model, revealing promising results after administering varying concentrations of the substance post-bus bleomycin exposure.
- - The study employed both in vivo and in vitro models, including A549 cell lines, to analyze lung tissue damage and identified that Tanshinone IIA effectively mitigated oxidative stress and cell death through the MAPK signaling pathway.
- - Findings indicate that Tanshinone IIA may delay PF progression by reducing oxidative stress and lowering pyroptosis in epithelial cells, offering potential new treatment strategies for PF.
Impact of dexmedetomidine-assisted anesthesia in elderly patients undergoing radical resection of colon cancer.
World J Gastrointest Surg
September 2024
Article Synopsis
- The study investigates the use of dexmedetomidine (Dex), an α2-adrenergic receptor agonist, during radical colon cancer surgery under general anesthesia in elderly patients, focusing on its potential benefits for hemodynamic stability and postoperative recovery.
- Conducted on 165 patients, the research compares a Dex group to a control group receiving normal saline, assessing various health indicators like hemodynamic changes, inflammatory factors, and sedation levels.
- Results indicate that the Dex group experienced less fluctuation in heart rate and blood pressure, improved lung function, reduced inflammation, and higher sedation levels post-surgery, suggesting Dex could enhance safety and recovery in elderly patients undergoing this procedure.
Application value of dexmedetomidine in anesthesia for elderly patients undergoing radical colon cancer surgery.
World J Gastrointest Surg
August 2024
Background: Colon cancer presents a substantial risk to the well-being of elderly people worldwide. With advancements in medical technology, surgical treatment has become the primary approach for managing colon cancer patients. However, due to age-related physiological changes, especially a decline in cognitive function, older patients are more susceptible to the effects of surgery and anesthesia, increasing the relative risk of postoperative cognitive dysfunction (POCD).
View Article and Find Full Text PDFThe aim of this study was to explore the mechanism underlying the cardioprotection bestowed by chronic intermittent hypobaric hypoxia (CIHH) against ischemia/reperfusion (I/R) injury in developing rats. Neonatal male rats were subjected to CIHH treatments that simulated an altitude of 3000 m a.s.
View Article and Find Full Text PDFBackground: Conventional hyperbaric spinal anaesthesia solution (SAS) with 8% glucose and low-dose bupivacaine may reduce the incidence of hypotension in caesarean section compared to standard doses, and marginally hyperbaric SAS (≤0.8% glucose) can induce a lower block level and a lower incidence of hypotension in nonobstetric patients than conventional 8% glucose SAS.
Objective: The objective of this study was to evaluate the clinical efficacy of marginally hyperbaric low-dose bupivacaine solutions used for spinal anaesthesia during caesarean section.
Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the rat.
Sheng Li Xue Bao
August 2009
The aim of the present study was to investigate the effect of polydatin on apoptosis induced by ischemia/reperfusion (I/R) in rat myocardium and to explore the underlying mechanism. Adult male Sprague-Dawley (SD) rats were randomly divided into control, I/R and polydatin (50 mumol/L) groups. On the Langendorff apparatus, isolated rat heart was subjected to 30-min global ischemia followed by 60-min reperfusion.
View Article and Find Full Text PDFThe aim of this study is to investigate the effects of chronic intermittent hypobaric hypoxia (IHH) and chronic continuous hypobaric hypoxia (CHH) on hemodynamics under basic normoxia and acute hypoxia conditions and to find the difference of two types of chronic hypoxia. Forty adult male Sprague-Dawley (SD) rats were randomly divided into 5 groups: Control group (CON), 28 days IHH group (IHH28), 42 days IHH group (IHH42), 28 days CHH group (CHH28) and 42 days CHH group (CHH42). The rats in IHH groups were treated with intermittent hypoxia (11.
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