Clinical study of Tc-Rituximab combined with dyes double tracing for axillary sentinel lymph node biopsy after neoadjuvant chemotherapy for breast cancer.

Background And Objective: Whether sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) for breast cancer is an alternative to axillary lymph node dissection (ALND) remains controversial. In this study, the results of SLNB performed with Tc-Rituximab combined with dyes were analyzed, and the application value of the double-tracing method of Tc-Rituximab combined with dyes in SLNB after breast cancer NAC was evaluated, the feasibility of SLNB after NAC and the clinical application of the novel tracer Tc-Rituximab and its value in internal mammary lymph node(IMLN) was discussed.

Methods: A retrospective analysis of 106 breast cancer patients who underwent post-NAC SLNB from August 2019 to August 2023 at Fujian Provincial Hospital, where SLNB was performed using Tc-Rituximab combined with dye imaging or dye imaging alone.

The relationship between resting metabolic rate and hyperuricemia: is a higher metabolic rate better?

Basal metabolic rate, resting metabolic rate, and resting energy expenditure are frequently utilised for the same research aims, but the underlying mechanisms separating them from human metabolic rate and metabolic disease remain poorly understood.Furthermore, specific recommendations for the prevention and management of hyperuricemia in populations with different resting metabolic rates have not been proposed, or how to reduce the public health burden of hyperuricemia based on resting metabolic rate and other factors have not been explored.[Methods] From 2011 to 2018, we selected 3268 adult participants from the National Health and Nutrition Examination Survey (NHANES).

S-nitrosylated NEDD4 exacerbates gouty arthritis by upregulating NOD1 to induce pyroptosis.

Gouty arthritis (GA) is a common inflammatory disease which has no effective treatments. Pyroptosis has been reported to exacerbate the progression of GA. We aimed to explore the molecular mechanism by which S-nitrosylated NEDD4 accelerates GA progression by regulating pyroptosis.

Experimental research on fungal inhibition using dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase.

: Onychomycosis is characterized by high transmission and low recovery rates, leading to a lack of optimal treatments. This study used dissolving microneedles as drug carriers to design dual-loaded DMN patches with β-1,3-glucanase and terbinafine hydrochloride nanoemulsion. : Dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase (Gls-TBH-NE-DMN) were prepared using the centrifugal molding method.

Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.

Ethnopharmacological Relevance: Antler base (Cervus nippon Temminck), a traditional Chinese medicine, is categorized as deer antler. Antler base extracts can delay osteoarthritis (OA); however, the underlying molecular pathways and effective substances remain unclear.

Aim Of The Study: to clarify the potential mechanism of action and effective substance structure of Cervus nippon Temminck antler base peptides (CNCPs) in improving OA.

Effect and mechanism of on intestinal microecology in rats with hyperuricemia.

Introduction: Hyperuricemia (HUA) is characterized by metabolic abnormalities in purine metabolism, leading to an excessive accumulation of uric acid in the bloodstream. This condition is not only prevalent but also significantly linked to the exacerbation of various chronic diseases, including renal impairment. Notably, asymptomatic hyperuricemia is frequently associated with inflammatory responses and alterations in intestinal microbiota.

Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015-2018.

the high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio and hyperuricemia among the population of the United States, the ratio still has predictive value for cardiovascular disease in middle age. Methods 4,780 adult participators from the National Health and Nutrition Examination Survey (NHANES) were involved in this research. Through the NHANES laboratory testing, all biochemical indications were discovered.

Evolution of sarcopenia status and risk of incident cardiovascular disease.

Aims: Sarcopenia is an emerging risk factor for cardiovascular disease (CVD). However, previous studies did not take into consideration the cardiovascular impact of the changes in sarcopenia status. We investigated the relationship between changes in sarcopenia status and incident CVD.

Analysis of the lymph node metastasis distribution in patients with invasive resectable non-small cell lung cancer.

Background: The current standard for the surgical management of lung cancer involves anatomic lung resection combined with systemic lymph node dissection/sampling. The purpose of this study was to investigate the patterns of pathological lymph nodes in invasive non-small cell lung cancer (NSCLC), explore the occurrence in lymph node metastasis (LNM), and provide recommendations for optimal lymph node resection/sampling in lung cancer operation.

Methods: There were 1,678 patients with NSCLC who underwent lobectomy between 2018 and 2021 at the Taizhou Hospital of Zhejiang Province were reviewed retrospectively.

Immunogenicity Assessment of a 14-Valent Human Papillomavirus Vaccine Candidate in Mice.

Background: Cervical cancer ranks as the fourth most common cancer affecting women globally, with HPV as the primary etiology agent. Prophylactic HPV vaccines have substantially reduced the incidence of cervical cancer.

Methods: This study assessed the immunogenicity of SCT1000, a 14-valent recombinant virus-like particle (VLP) vaccine developed by Sinocelltech, Ltd.

Correction: Shen et al. The Isolation, Structural Characterization and Anti-Inflammatory Potentials of Neutral Polysaccharides from the Roots of Fort. 2024, , 2683.

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[Effect and Mechanism of Uric Acid in Regulating Larval Growth and Development of ].

Objective To explore the effect and mechanism of uric acid (UA) in regulating the larval growth and development of . Methods A total of 1350 newly hatched first-instar larvae of wild-type (W1118) were collected,and the model of hyperuricemia was constructed with a high purine diet.The larvae were assigned into three groups (=150):control (standard corn meal medium),low-dose adenine (corn meal medium containing 0.

Progress in modeling avian hyperuricemia and gout (Review).

Human organ tissue is vulnerable to hyperuricemia (HUA), which negatively impacts quality of life, particularly when it progresses to gout. Chicken uric acid formation and metabolism are similar to human uric acid metabolism; therefore, theoretically, the genesis and progression of human HUA and gout may be similar to those of poultry models. The present review explored HUA and gout and the progress of poultry-induced HUA and gout models.

Needs for rehabilitation in China: Estimates based on the Global Burden of Disease Study 1990-2019.

Background: As an essential part of health services, rehabilitation is of great significance to improve the health and quality of life of the whole population. Accelerating aging calls for a significant expansion of rehabilitation services in China, but rehabilitation needs remain unclear. We conducted the study to explore the rehabilitation needs in China and project the trend of rehabilitation needs from 2020 to 2034.

Research progress in the treatment of an immune system disease-type 1 diabetes-by regulating the intestinal flora with Chinese medicine and food homologous drugs.

Type 1 diabetes (T1D) is a specific autoimmune disease related to genetic and autoimmune factors. Recent studies have found that the intestinal flora is one of the important environmental factors in the development of T1D. The gut microbiota is the largest microbiota in the human body and has a significant impact on material and energy metabolism.

DUSP1 Mitigates MSU-Induced Immune Response in Gouty Arthritis Reinforcing Autophagy.

Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation. Activation of the Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome plays a critical role in the onset and progression of GA.

The Isolation, Structural Characterization and Anti-Inflammatory Potentials of Neutral Polysaccharides from the Roots of Fort.

Polysaccharides have been assessed as a potential natural active component in Chinese herbal medicine with anti-inflammatory properties. However, the complex and indefinite structures of polysaccharides limit their applications. This study explains the structures and anti-inflammatory potentials of three neutral polysaccharides, RIP-A1 (M 1.

Joint association of diabetes mellitus and inflammation status with biological ageing acceleration and premature mortality.

Background: We aimed to investigate the associations of diabetes mellitus (DM) and C-reactive protein (CRP) with biological ageing acceleration and mortality risk.

Methods: We analyzed data from 41,634 adults with CRP and DM at baseline. Subjects were categorized into high CRP (>3 mg/L) and low CRP (≤3 mg/L) groups.

Association of adverse childhood experiences with poor health condition among middle-aged and elderly adults in the United States: A nationally retrospective cohort study.

Background: The specific effects of adverse childhood experiences (ACEs) in adulthood and senectitude were less known. We aim to examine the relationship between early ACEs and overall health condition as well as specific dimensions in the middle-aged and elderly population.

Methods: In the 2019-2021 Behavioral Risk Factor Surveillance System Study, robust Poisson regression models were used to estimate the relationship between ACE exposure and current health status among adults aged 45 ≥ years.

BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis.

Background: Gouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyroptosis; however, the underlying regulatory mechanisms have yet to be fully elucidated. The present research endeavors to elucidate the regulatory mechanisms underpinning this MSU-induced pyroptotic cascade in GA.

Methods: J774 cells were exposed to lipopolysaccharide and MSU crystals to establish in vitro GA models, whereas C57BL/6 J male mice received MSU crystal injections to mimic in vivo GA conditions.

Decreased cobalamin sensitivity and biological aging acceleration in the general population.

Background: The evidence on the association between cobalamin (Cbl) and aging or relevant outcomes is limited and controversial. We aimed to investigate the relationships between cobalamin intake- and function-related biomarkers and biological aging.

Methods: The study encompassed 22,812 participants aged 20 years and older from the National Health and Nutrition Examination Survey.

The association between serum methylmalonic acid, cobalamin-related biomarkers, and long-term mortality risk in cancer survivors: a prospective cohort study.

Background: Elevated serum methylmalonic acid (MMA), a marker of cobalamin (vitamin B12) deficiency, has been linked to cancer progression. However, the impact of MMA or cobalamin on mortality risk in cancer survivors remains unknown.

Objectives: To explore the relationship between MMA, serum, dietary, and supplement of cobalamin, MMA metabolism-related genes, and poor prognosis in adult cancer survivors.

Research progress on the mechanism of TCM regulating intestinal microbiota in the treatment of DM mellitus.

In recent years, with the improvement of people's living standards, the incidence of DM has increased year by year in China. DM is a common metabolic syndrome characterized by hyperglycemia caused by genetic, environmental and other factors. At the same time, long-term suffering from DM will also have an impact on the heart, blood vessels, eyes, kidneys and nerves, and associated serious diseases.