Fatty acid profile, lipid indices and lipid peroxidation in chicken meat: the effect of dietary vegetable oils and vitamin C/selenium supplement.

Background: Incorporating vegetable oils into chicken diets enhances the meat's beneficial fatty acids but accelerates lipid peroxidation, necessitating dietary antioxidants. This study evaluated the effect of a combination of 150 mg kg vitamin C and 0.3 mg kg organic selenium on the fatty acid profile and lipid peroxidation of chicken meat, focusing on the calculation of fatty acid metabolism indices in diets containing either rapeseed oil (RO) or pumpkin seed oil (PO).

β-Lactam Potentiating Activity, Molecular Docking, and ADMET Analysis of 3-Substituted Coumarins.

Drug resistance is a pivotal issue in the treatment of bacterial infections. Thus, discovering alternative drugs is necessary to control antibiotic-resistant bacteria, such as β-lactamase-producing Staphylococcus aureus. Coumarins with C-3 modifications have different inhibitory effects on bacteria, including resistant ones.

Phenolic Compound Profile, Antimicrobial Activity, and Adjuvant Potential of Ethanolic Extracts From Bioproducts of Melipona quinquefasciata (Lepeletier, 1836).

Antimicrobial resistance is a global emergency driven by the selection of multiresistant strains. As a result, research has intensified on products with direct antimicrobial effects or as adjuvants to antibiotics and antifungals. Products from stingless bees of the Melipona genus have shown biological properties, such as antimicrobial activity.

Lupeol as a Potential Inhibitor of NorA Efflux Pumps in Staphylococcus aureus: In Silico and In Vitro Evidence.

Antimicrobial resistance remains one of the major challenges to global public health, compromising the effectiveness of treatments and contributing to increased morbidity and mortality associated with bacterial infections. Among the mechanisms involved, efflux pumps-such as NorA, expressed in resistant strains of Staphylococcus aureus-are particularly noteworthy. These transport proteins actively expel antibiotics from the cell, reducing their intracellular concentration.

Chemical Composition, Antimicrobial, and Drug-Potentiating Activities of Extracts From Tocoyena formosa (Cham. & Schltdl.) K.Schum. (Rubiaceae).

Tocoyena formosa is a medicinal species used to treat gastrointestinal disorders, which may include infections. This study analyzed the hexane (HETF) and ethanolic (EETF) extracts of T. formosa to identify their chemical composition and antimicrobial potential.

Efficacy of Essential Oil of Algrizea minor Sobral, Faria & Proença (Myrtaceae) in Combating Methicillin-resistant Staphylococcus aureus: Antibacterial and Virulence Modulation Studies Conducted In Vitro and In Vivo.

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are difficult to treat due to its resistance profile and the scarcity of new antibiotics, necessitating alternative therapeutic strategies. This study explores the antibacterial, antivirulence, and in vivo effects of Algrizea minor essential oil (EOAM) against MRSA isolates. Chemical analysis identified β-pinene (38.

Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections.

Antimicrobial resistance is an increasing threat to public health, with alarming estimates of mortality rates. In this context, the clinical properties of Varronia curassavica Jacq. are highlighted due to its biological and pharmacological activities.

Impact of heavy metal toxicity on the human health and environment.

Heavy metals are among the major categories of pollutants that are widespread and have enormous potential to affect the environment and public health. Today, the toxicity of heavy metals has become a challenge since it is highly toxic and can accumulate in the body system. Heavy metal contamination results from various natural and anthropogenic activities that release these elements into the environment.

Lipopolysaccharide-induced abdominal nociception behavioral model in adult zebrafish (Danio rerio).

In this study a behavioral model of LPS-induced abdominal nociception was developed on adult zebrafish (Danio rerio), aZF. Initially, the toxicity of different LPS concentrations was assessed. The abdominal nociceptive response to the lowest LPS concentration was then analyzed, and the impact of sex on this nociceptive response was evaluated.

Memory-Enhancing Effects of Daidzin, Possibly Through Dopaminergic and AChEergic Dependent Pathways.

Background: The soy isoflavone daidzin (DZN) possesses cognitive-enhancing effects in animals.

Objectives: However, the mechanism for this effect is yet to be discovered.

Methods: For this, we investigate its memory-enhancing capacity using the mouse models of marble burying, dust removal, an open-field study, and in silico studies.

Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the 1199B Strain.

Substances with antibacterial properties have become crucial in light of the continuous increase in infections caused by multidrug-resistant bacteria. In this context, thiadiazines have emerged as heterocyclic compounds already known for their pharmacological activities. However, their potential as antibacterial agents and inhibitors of the efflux system found in resistant bacteria remains poorly understood.

Electronic properties and adjuvant effect of riparins I-IV: Inhibition of β-lactamase and QacC efflux pump in Staphylococcus aureus K4100.

Staphylococcus aureus is a leading cause of nosocomial infections, posing a significant health threat due to its resistance mechanisms, particularly involving β-lactamase enzymes and efflux pumps. Targeting these mechanisms is crucial to restore the efficacy of antibiotics. This study characterized the electronic properties of riparins I, II, III, and IV and evaluated their effects on the β-lactamase enzyme and the QacC efflux pump in the S.

Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies.

Epigenetic mechanisms play a crucial role in the normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of these processes can result in changes to gene function and the transformation of cells into a malignant state. Cancer is characterized by widespread alterations in the epigenetic landscape, revealing that it involves not only genetic mutations but also epigenetic abnormalities.

Modifying-antibiotic action of Hecogenin Acetate as an alternative to combat bacterial infections.

Bacterial infections are pathologies with specific morbidity and mortality that disrupt a high level of care in health systems. These diseases are treated using antibacterial drugs. Antibiotics are drugs that act by inhibiting bacterial growth or promoting the death of microorganisms.

Utilization of Tommy Atkins Mango Peel as a Sustainable Biosorbent for the Removal of Pb(II) Ions in Water.

The contamination of water resources by heavy metals, such as lead ions, represents a serious environmental and public health problem, requiring effective treatment methods. This study evaluated the adsorptive potential of Tommy Atkins mango peel as a biosorbent for removing lead ions from synthetic aqueous solutions. The mango peels were obtained in the city of Crato, CE, dried in an oven at 313.

Antibacterial and Antioxidant Properties of Geopropolis Extracts from Stingless Bees (Meliponinae) Occurring in Brazilian Territory.

Geopropolis resins are produced by stingless bees (Meliponinae) from a variety of compounds found in plants. The resins present unique physicochemical characteristics, and the study of their therapeutic properties and potential pharmacological applications is ongoing. This study focuses on exploring the biological properties, antioxidant and antibacterial associated with geopropolis resin extracts produced in Brazil.

Antifungal Action of Valencene and Nootkatone Compounds in Association with Fluconazole and Their Mechanism of Action Against Candida spp. and Pichia kudriavzevii Strains.

Candidemia is a public health challenge as it causes thousands of annual deaths and combating it has become difficult due to the development of resistance in Candida spp. Compounds derived from natural products may counter this resistance. Therefore, we evaluate the intrinsic and combined antifungal activity of valencene and nootkatone compounds and their possible mechanism of action against Candida spp.

Leveraging infrared spectroscopy for cocoa content prediction: A dual approach with Kohonen neural network and multivariate modeling.

People of all ages enjoy chocolate, and its popularity is attributed to its pleasant taste and aroma, as well as its associated health benefits. Produced through both artisanal and industrial processes, which involve harvesting, selecting, fermenting, roasting and grinding cocoa beans, chocolate has a diverse chemical composition. It contains stimulants for the central nervous system, including caffeine and theobromine, and antioxidants and flavonoids, some of which are associated with promoting cardiovascular health, circulatory function, alertness, and attention.

Chemical Characterization and Antibiotic-Enhancing Activity of the Essential Oils of Propolis of .

This study investigated the chemical composition and potential antibacterial activity of the essential oils from the propolis of (MQP) in samples collected from the cities of Paranaguá and Guaratuba, Paraná, Brazil, during summer and winter. The chemical composition of the oils was analyzed by GC-MS, and their minimum inhibitory concentration (MIC) was determined against standard ATCC strains and some clinical isolates ( 06 and 10). The essential oils' MICs were determined using microdilution in 96-well plates and showed no significant antibacterial activity (MIC ≥ 1024 μg/mL) when used alone.

trans-Ferulic Acid Antagonizes the Anti-Inflammatory Activity of Etoricoxib: Possible Interaction of COX-1 and NOS.

This study emphasizes to investigate the modulatory activity of trans-ferulic acid (TFA) on anti-inflammatory activity of etoricoxib (ETO) and underlying mechanisms via formalin-induced licking and paw edema model and in silico study. Inflammation was induced by injecting formalin (50 µL) into the right hind paw of mice. The animals were treated with different doses of TFA (25, 50, and 75 mg/kg, p.

ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of carrying the QacA/B efflux pump gene.

The Gram-positive bacterium is responsible for causing both community-acquired and healthcare-associated infections, and it exhibits high antibiotic resistance due to the presence of efflux pumps. These pumps, such as QacA and QacB, are proteins that expel toxic substances, including antibiotics, making infection treatment more difficult. Among the alternatives to combat this resistance are terpenes, like β-caryophyllene, which have the potential to inhibit these efflux pumps due to their nonpolar nature.

Toxicological assessment of citral and geraniol: Efflux pump inhibition in and invertebrate toxicity.

This study aimed to evaluate the antibacterial activity against multi-drug-resistant strains carrying efflux pumps and assess their toxicity on and models. Microdilution tests in broth were performed to determine the Minimum Inhibitory Concentration (MIC). The efflux pump inhibition was evaluated by analyzing the reduction in antibiotic MIC and Ethidium Bromide (EtBr) MIC when combined with the products.

Evaluation of the antibacterial and inhibitory activity of the NorA and TetK efflux pumps of Staphylococcus aureus by p-coumaric acid.

The NorA and TetK efflux pumps mediate resistance to fluoroquinolone and tetracycline antibiotics by actively extruding these compounds and reducing their intracellular concentrations. Consequently, intense research has focused on inhibiting these efflux mechanisms using antimicrobial agents derived from natural or synthetic sources. This study used Fourier transform infrared spectroscopy (ATR-FTIR) to analyze the various functional groups present in p-coumaric acid.

Phytoceutical isoquercitrin and ethanolic extracts from pequi (Caryocar coriaceum Wittm) reverse alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio).

Pharmacotherapy in Alcohol Withdrawal Syndrome (AWS), which is a mental disorder, generally involves benzodiazepines due to their action via GABA, but their side effects, such as excessive sedation, mental confusion and risk of dependence, are considerable. It is important to investigate the anxiolytic potential of plants such as Caryocar coriaceum, due to the presence of secondary metabolic compounds, such as isoquercitrin, capable of promoting the reduction of anxiety during AWS. We evaluated the anxiolytic-like potential of ethanolic extracts from the leaves (EEPL) and pulp (EEPP) of C.

Antinociceptive Potential of L. Bark Extract and Caffeic Acid: Insights into Pain Modulation Pathways.

This study evaluated the antinociceptive effect of the L. bark extract (HEXA) and its primary component, caffeic acid (CA), through in vivo assays. : The antinociceptive properties were assessed using abdominal writhing, hot plate, and Von Frey tests.