Publications by authors named "Hansong Qi"
HSV-1 ICP22 condensates impair host transcription by depleting promoter RNAPII Ser-2P occupation.
Front Microbiol
February 2025
Herpes simplex virus type I (HSV-1) infection-induced host transcript ion shutdown is one of the most critical hallmarks of viral lytic infection. However, how HSV-1 and which viral factors accomplish this dramatic effect is not well understood. In this study, we show that ICP22-defined condensates shutdown host global transcription but facilitate viral transcription.
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- * The viral protein ICP22 creates a specialized area (VICE domain) that aids in managing RNAPII through a process called liquid-liquid phase separation.
- * A specific function of the virus's UL36 protein helps protect RNAPII from degradation, ensuring continued viral gene expression even when host transcription is inhibited.
Article Synopsis
- PRV TJ strain causes more severe neurological symptoms and higher mortality in piglets and mice compared to the PRV SC strain, but the reason for this difference in virulence is not fully understood.
- This study explores the neurotropism differences between the two strains and finds that PRV TJ can enter neural cells more effectively, although both strains have similar replication and transport capabilities.
- Mutations in the viral envelope glycoprotein gD play a crucial role in enhancing the attachment and penetration of PRV TJ, indicating that changes in these proteins significantly influence viral invasion rather than virulence alone.
Pseudorabies virus (PRV) is the causative agent of pseudorabies (PR). It can infect a wide range of mammals. PRV infection can cause severe acute neuropathy (the so-called "mad itch") in nonnatural hosts.
View Article and Find Full Text PDFA NanoLuc Luciferase Reporter Pseudorabies Virus for Live Imaging and Quantification of Viral Infection.
Front Vet Sci
September 2020
Pseudorabies (PR), also known as Aujeszky's disease, is an acute infectious disease of pigs, resulting in significant economic losses to the pig industry in many countries. Since 2011, PR outbreaks have occurred in many Bartha-K61-vaccinated pig farms in China. The emerging pseudorabies virus (PRV) variants possess higher pathogenicity in pigs and mice than the strains isolated before.
View Article and Find Full Text PDFPseudorabies virus (PRV) is a member of subfamily, its neurotropism and latency infection attract the attention of many scientists. PRV tagged with a fluorescent reporter gene as a tracker has been used to analyze neuronal circuits, including anterograde and retrograde. In this study, we used fosmid library to construct a rapid and efficient platform to generate recombinant PRV.
View Article and Find Full Text PDF[Transport of alphaherpesviruses in neurons--axonal"shuttling"].
Sheng Wu Gong Cheng Xue Bao
August 2019
After a long-term co-evolution, alphaherpesviruses have established mutual adaptability with their hosts. Some alphaherpesviruses have typical neurotropic characteristics, which have received extensive attention and in-depth research. Neurotropic alphaherpesviruses can break through the host barrier to infect neurons and multiply in large numbers in the neuron cell body to complete further proliferation or establish latent infection in the cell body.
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