Association Between Caffeine Intake and Bowel Habits and Inflammatory Bowel Disease: A Population-Based Study.

Background: The effect of caffeine in coffee, a popular beverage, on gastrointestinal symptoms has been the subject of ongoing debate worldwide. The present study explored the association between caffeine intake and bowel habits and Inflammatory bowel disease (IBD).

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2010 were utilized for this cross-sectional survey.

Allergic rhinitis in college students at Dongguan: a cross-sectional survey on disease burden, knowledge, and self-management.

This study examined the prevalence, clinical characteristics, disease knowledge, and quality of life impact of allergic rhinitis (AR) among college students in Dongguan, China. Using a customized questionnaire, we surveyed 1,531 participants (response rate: 85.1%) and identified an AR prevalence of 18.

Association between the NHHR and hepatic steatosis and liver fibrosis: a population-based study.

Non-alcoholic fatty liver disease (NAFLD) is strongly associated with dyslipidemia, and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a more comprehensive indicator of lipids. This study aimed to investigate the association between NHHR and hepatic steatosis and liver fibrosis. The 2017-2020 national health and nutrition examination survey (NHANES) dataset was used for the cross-sectional survey.

Association of per- and polyfluoroalkyl substances with gout risk: a cross-sectional analysis of NHANES 2007-2018 data emphasizing mixture effects.

Objective: This study examined associations between serum concentrations of per- and polyfluoroalkyl substances (PFASs) and gout risk in the U.S. adult population using the National Health and Nutrition Examination Survey (NHANES) 2007-2018 data.

MOVER tests for non-inferiority of the difference between two binary-outcome treatments in the matched-pairs design.

A non-inferiority trial is usually conducted to investigate whether a new drug/treatment is no worse than a reference drug/treatment by a small, pre-specified, non-inferiority margin. This study aimed to assess the non-inferiority of the difference between two binary-outcome treatments in a matched-pairs design based on the method of variance of estimates recovery (MOVER). The processes for estimating the confidence interval of a single proportion included in the MOVER are the Wilson score interval, Agresti - Coull interval, Jeffreys interval, modified Jeffreys interval, score method with continuity correction, and arcsin interval.

Comparison of renal safety and bone mineral density of tenofovir and entecavir in patients with chronic hepatitis B: a systematic review and meta-analysis.

Objectives: Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as first-line treatments for chronic hepatitis B (CHB). However, the safety of these two drugs remains controversial. This study aimed to evaluate and compare renal function and bone mineral density in patients with CHB who took TDF or ETV.

Columbamine suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK1/2 MAPK signaling pathways.

Hepatocellular carcinoma (HCC) as primary liver cancer in adults is the most common cause led to internal cirrhosis responsible for patients' death, which resulted in nearly a million deaths worldwide on both males and females in the developing and developed countries. Unfortunately, up to date, there are no highly effective treatment of medicine on HCC as lack of comprehensive cellular and molecular mechanism. According to the sources of human ancient history of medicine, traditional medicine could provide unique treatment to discontinue the challenging HCC.

IL-17A inhibits autophagic activity of HCC cells by inhibiting the degradation of Bcl2.

Hepatocellular carcinoma (HCC) is associated with poor prognosis due to many unknowns about its inflammatory microenvironment. As a pivotal proinflammatory cytokine, IL-17A exerts a protective effect on the survival and function of HCC cells. It is widely accepted that IL-17A plays an important role in regulating autophagy.