Exercise suppresses osteoclastogenesis by increasing the secretion of muscle-derived L-β-aminoisobutyric acid.

Background: Exercise is a key strategy for combating bone loss in individuals with postmenopausal osteoporosis (PMOP). L-β-aminoisobutyric acid (L-BAIBA), an exercise-responsive myokine, is secreted at elevated levels during physical activity. However, the role of exercise-induced L-BAIBA secretion in PMOP remains unclear.

WTX-L/β-arrestin2/LCN2 axis controls vulnerability to ferroptosis in gastric cancer.

Gastric cancer (GC) is one of the most prevalent and lethal cancers worldwide. Ferroptosis is a form of iron-dependent regulated cell death emerging as a promising strategy for cancer therapy, whereas the regulation mechanism remains unclear. WTX has been recognized as a potential tumor suppressor, but attempts at targeted therapy have not achieved substantial progress.

In vitro corrosion and biocompatibility of additively manufactured biodegradable molybdenum.

Recently, molybdenum (Mo) has been recognized a promising biodegradable metal, however, it is difficult to be processed through traditional deformation or machining due to its high strength & hardness. Additive manufacturing is a good way to get rid of this dilemma. Here, Mo components were directly fabricated with fine Mo powder through selective laser melting (SLM).

Prrx1 promotes resistance to temozolomide by upregulating ABCC1 and inducing vasculogenic mimicry in glioma.

Gliomas are the most common primary brain tumors with dismal prognoses. Temozolomide (TMZ), the frontline therapeutic agent for gliomas, has shown limited clinical benefit primarily due to the acquired chemoresistance. Although growing evidence has suggested that the multi-drug resistance phenotype and abnormal vascular microenvironment are responsible for the intrinsic and extrinsic TMZ resistance, the molecular mechanism of TMZ resistance remains to be elucidated.

Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice.

Aims: Gap junction intercellular communication (GJIC) in osteocytes is impaired by oxidative stress, which is associated with age-related bone loss. Ageing is accompanied by the accumulation of advanced oxidation protein products (AOPPs). However, it is still unknown whether AOPP accumulation is involved in the impairment of osteocytes' GJIC.

Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis.

Enhanced osteoclastogenesis is one of the major causes of age-related bone loss. Aging is accompanied by accumulation of advanced oxidation protein products (AOPPs). However, whether AOPPs accumulation contributing to the osteoclastogenesis with aging remains unclear.

LncRNA NEAT1 Promotes Gastric Cancer Progression Through miR-17-5p/TGFβR2 Axis Up-Regulated Angiogenesis.

Background: Long non-coding RNAs (lncRNAs) have been indicated to play critical roles in gastric cancer (GC) tumorigenesis and progression. However, their roles in GC remain to be further elucidated.

Methods: RT-qPCR and fluorescence hybridzation (FISH) were conducted to detect the expression of lncRNA NEAT1 in GC tissues and cell lines.

Leukemia Inhibitory Factor Receptor Suppresses the Metastasis of Clear Cell Renal Cell Carcinoma Through Negative Regulation of the Yes-Associated Protein.

The role of leukemia inhibitory factor receptor (LIFR), which is important in the signal transduction of the interleukin-6 cytokine family, is still undefined in clear cell renal cell carcinoma (ccRCC). Thus, we examined the function and mechanism of LIFR in ccRCC. Low LIFR expression correlated with a poor prognosis and an aggressive tumor phenotype.

Highly selective aerobic oxidation of alcohol catalyzed by a gold(I) complex with an anionic ligand.

Highly selective aerobic oxidation of alcohols to carbonyl compounds was catalyzed by a gold(I) complex with an anionic ligand in solution.