BrainAgeNeXt: Advancing brain age modeling for individuals with multiple sclerosis.

Aging is associated with structural brain changes, cognitive decline, and neurodegenerative diseases. Brain age, an imaging biomarker sensitive to deviations from healthy aging, offers insights into structural aging variations and is a potential prognostic biomarker in neurodegenerative conditions. This study introduces BrainAgeNeXt, a novel convolutional neural network inspired by the MedNeXt framework, designed to predict brain age from T1-weighted magnetic resonance imaging (MRI) scans.

Detection of Carbapenem-Resistant Genes Among Clinical Isolates of Acinetobacter baumannii in a Tertiary Care Hospital.

Background , an opportunistic pathogen associated with healthcare-associated infections, poses a major clinical challenge due to its ability to develop resistance to multiple drugs, particularly carbapenems. Objective The aim of the study was to detect the presence of different carbapenem resistance genes in clinical isolates of . Materials and methods A cross-sectional study was conducted from March 2023 to December 2023 in the Department of Microbiology of a tertiary care hospital, India.

Isolation, morphological, and molecular characterization of a native strain from the Mid-Indian Himalayas with insights into biocontrol potential.

Entomopathogenic nematodes (EPNs) from the families Steinernematidae and Heterorhabditidae are biocontrol agents for the management of a wide range of insect pests. There is a tremendous opportunity for the discovery of new nematode strains and species adapted to local environmental conditions and insect pests. Therefore, in the present study, efforts were made to isolate EPN strains/species from the Northwestern Himalayas (NWH) region.

Interpenetrated Three-Dimensional Covalent Organic Framework for Selective Adsorption of CH Over CO and CH.

Selective separation of acetylene (CH) from carbon dioxide (CO) and ethylene (CH) mixtures is critical in the petrochemical industry due to their similar size and physicochemical properties. Developing three-dimensional porous covalent organic frameworks (3D COFs) remains challenging in this context. In this work, a non-symmetrical 2-phenyl pyridine based three-dimensional covalent organic framework (COF-PPy) has been synthesized, which features a rare dia-C9 fold interpenetrated structure as suggested by computational simulations.

Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins.

Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns resulting in motor and cognitive impairment. Therapeutic hypothermia is the only treatment approved for HIE. Consequently, there is a critical requirement for additional treatments for hypoxic-ischemic (HI) brain injury because hypothermia is only partially protective.

Investigation of alternative materials for BOF slag in landfill biogeochemical cover for carbon dioxide sequestration.

Landfill gas (LFG), primarily composed of methane (CH) and carbon dioxide (CO), continues to escape from municipal solid waste (MSW) landfills despite mitigation strategies like gas collection systems and soil covers. A novel biogeochemical cover (BGCC), developed at the University of Illinois Chicago, aims to mitigate these fugitive emissions by incorporating a biochar-amended soil (BAS) layer for CH oxidation and a basic oxygen furnace (BOF) slag layer for CO sequestration. However, the limited availability of BOF slag near landfill sites presents a barrier to large-scale implementation, necessitating the identification of alternative CO-sequestering materials.

Evaluation of zirconia and titanium abutments on peri-implant tissues: A comparative study.

The comparative effect of zirconia and titanium abutments on peri-implant hard and soft tissues is of interest to dentists. Hence, a total of 40 patients with single-tooth implants in the posterior region were selected and divided into two groups: zirconia abutments (Group A, n=20) and titanium abutments (Group B, n=20). Clinical parameters, including probing depth (PD), bleeding on probing (BOP) and peri-implant marginal bone level (MBL), were evaluated at baseline, 3 months and 6 months post-implant placement.

Primary congenital intracranial lipoma with extracranial extension in a pediatric patient: A case report and literature review.

Background: Congenital intracranial lipomas are rare, representing only 0.1-0.5% of brain tumors, and are typically asymptomatic.

Investigation of biogeochemical landfill covers incorporating different biochars and alkaline industrial byproducts for landfill gas mitigation: A column experiment study.

Fugitive emissions of methane (CH) and carbon dioxide (CO) from municipal solid waste (MSW) landfills pose significant environmental risks if not captured. To address this, researchers at the University of Illinois Chicago developed a biogeochemical cover (BGCC) comprising a biochar-amended soil (BAS) layer and a basic oxygen furnace (BOF) slag layer to simultaneously mitigate CH and CO. Previous laboratory experiments with BGCC comprising pinewood-derived biochar (PW)-amended soil and BOF slag (BGCC-PWBOF) demonstrated substantial potential for CH and CO mitigation.

Endovascular Approach to Concurrent Anterior Cranial Fossa Dural AVF and Concurrent Flow-Related Ophthalmic Artery Aneurysm: A Case Study.

Dural arteriovenous fistulas (DAVFs) with concurrent flow-related ophthalmic artery aneurysms, particularly intraorbital aneurysms, are rare. Retrograde cortical blood flow and sinus thrombosis heighten the risk of rupture and optic nerve compression, yet treatment strategies remain poorly defined. This study aims to explore effective management for these complex cases.

Evaluation of the Effect of Different Contaminants on the Shear Bond Strength of Different Adhesive Systems - An Study.

Background: The bonding of restorative materials to tooth structure is made easier by dental adhesive solutions, which are essential in restorative dentistry. Nonetheless, there are a number of things that can affect how well they operate, such as oral environmental contaminants.

Methodology: The research utilized a regulated experimental framework, segmenting the samples into smaller groups to symbolize discrete contamination scenarios observed in dentistry settings, such as artificial saliva and Viscostat clear contamination prior to and following bonding agent curing.

Antiviral activity of ribosome inactivating proteins for management of plant viral infection.

In nature, plants exhibit various defense mechanisms to protect themselves from viral infection. Reported to harbor virus-inhibiting compounds like Ribosome inactivating proteins (RIPs). It's a matter of how we explore, identify, and utilize RIPs in managing a given stress.

Impact of Demographic, Clinical, and Preventive Factors on Caries Susceptibility and Cavitation in a Six-to-15-Year Cohort.

Introduction: Dental caries continues to represent one of the most widespread oral health challenges on a global scale, particularly in adolescents. This cross-sectional investigation examines the impact of demographic, clinical, and preventive factors on caries susceptibility and cavitation in children aged six to 15 years, thereby offering a thorough analysis of risk patterns and preventive strategies.

Materials And Methods: This prospective, cross-sectional study was conducted on 2,000 schoolchildren, aged six to 15 years.

Radiofrequency Enhancer to Recover Signal Dropouts in 7 Tesla Diffusion MRI.

Diffusion magnetic resonance imaging (dMRI) allows for a non-invasive visualization and quantitative assessment of white matter architecture in the brain by characterizing restrictions on the random motion of water molecules. Ultra-high field MRI scanners, such as those operating at 7 Tesla (7T) or higher, can boost the signal-to-noise ratio (SNR) to improve dMRI compared with what is attainable at conventional field strengths such as 3T or 1.5T.

Magnetically induced localized heating enabling rapid and efficient synthesis of metal-organic frameworks.

We demonstrate magnetic induction heating (MIH) with superparamagnetic iron oxide nanoparticles (IONPs) as a new rapid and energy-efficient methodology for synthesizing metal-organic frameworks (MOFs). Acting as localized heat sources, these IONPs overcome the energy losses associated with traditional solvothermal synthesis, which enables a fast, uniform, and highly energy-efficient heat transfer process. The versatility of this method is illustrated for the successful synthesis of three different benchmark MOFs in good yields with high crystallinity.

Development of a two-dimensional peptide functionalized-reduced graphene oxide biomaterial for wound care applications.

Increased incidences of antibiotic resistance have necessitated the development of novel wound disinfection strategies with minimal risk of resistance development. This study aimed at developing a biocompatible wound dressing biomaterial with the potential to treat acute and chronic wounds infected with multidrug-resistant . A multifunctional antibacterial nanoconjugate was synthesized by covalently coupling a synthetically designed peptide (DP1, , RFGRFLRKILRFLKK) with reduced graphene oxide (rGO).

BrainAgeNeXt: Advancing Brain Age Modeling for Individuals with Multiple Sclerosis.

Aging is associated with structural brain changes, cognitive decline, and neurodegenerative diseases. Brain age, an imaging biomarker sensitive to deviations from healthy aging, offers insights into structural aging variations and is a potential prognostic biomarker in neurodegenerative conditions. This study introduces BrainAgeNeXt, a novel convolutional neural network inspired by the MedNeXt framework, designed to predict brain age from T1-weighted magnetic resonance imaging (MRI) scans.

Energy-efficient synthetic antiferromagnetic skyrmion-based artificial neuronal device.

Magnetic skyrmions offer unique characteristics such as nanoscale size, particle-like behavior, topological stability, and low depinning current density. These properties make them promising candidates for next-generation spintronics-based memory and neuromorphic computing. However, one of their distinctive features is their tendency to deviate from the direction of the applied driving force that may lead to the skyrmion annihilation at the edge of nanotrack during skyrmion motion, known as the skyrmion Hall effect (SkHE).

Modified Carbapenem Inactivation Method and Ethylenediaminetetraacetic Acid (EDTA)-Carbapenem Inactivation Method for Detection of Carbapenemase-Producing Enterobacterales and Pseudomonas aeruginosa.

Introduction: The rising incidence of carbapenem resistance in Enterobacterales and is a concern. Since carbapenemase production is the primary resistance mechanism, detecting and identifying the genes responsible for it is crucial to effectively monitor its spread.

Objective: This study aims to detect positivity for the modified carbapenem inactivation method (mCIM) and ethylenediaminetetraacetic acid (EDTA)-carbapenem inactivation method (eCIM) for the detection of carbapenemase-producing Enterobacterales and .

Optimizing outcomes in multicompartmental brain tumor surgery: A comparative study of integrated endoscopic and microsurgical techniques versus endoscope-assisted microsurgery.

Background: Multicompartmental lesions within the central nervous system are challenging due to their complex anatomy. This study evaluates the efficacy, safety, and utility of hybrid endoscopic and microsurgery versus endoscope-assisted microsurgery(EAM) for excising these lesions.

Methods: A retrospective comparative analysis was conducted on patients who underwent multicompartmental brain tumor surgery, utilizing either hybrid endoscopic and microsurgical techniques with the Endocameleon Hopkins telescope featuring a rotating lens system and knob (Karl Storz GmbH & Co.

"Pediatric Spontaneous Intracranial Dissecting Aneurysms: Impact of Ischemic and Hemorrhagic Manifestations on Endovascular Treatment Strategies - Insights from a Developing World Setting".

Background: Pediatric spontaneous intracranial dissecting aneurysms are rare, but systematic studies comparing hemorrhagic and ischemic presentations are lacking. This study addresses gaps in understanding their epidemiology, clinical presentation, management, and outcome.

Methods: A retrospective analysis of 23 pediatric patients with nontraumatic intracranial dissecting aneurysms treated between July 2018 and December 2023 was conducted.