Subthalamic Theta-Alpha Local Field Potentials in OFF-Levodopa Dystonia in Parkinson's Disease.

Background: Dystonia affects an estimated 30% of patients with Parkinson's Disease (PD). While pallidal theta-alpha oscillations (4-10 Hz) have been found to characterize primary dystonia compared to beta oscillations (12-30 Hz) in PD, the electrophysiology underlying dystonia in PD remains unexplored.

Objectives: Explore the electrophysiology underlying dystonia in PD.

Direct Localization of the VIM/DRTT Using Quantitative Susceptibility Mapping in Essential Tremor: A Pilot MRI Study.

Background And Purpose: Accurate localization of the ventral intermediate nucleus (VIM) within the dentatorubrothalamic tract (DRTT) is critical for effective neurosurgical treatment of essential tremor (ET). This study evaluated the feasibility and anatomical specificity of quantitative susceptibility mapping (QSM) for direct VIM/DRTT visualization, comparing it with conventional diffusion tractography-based reconstructions.

Materials And Methods: Twenty-seven participants (10 healthy controls, 17 ET patients) were enrolled across two institutions and imaged on 3T MRI systems.

Twelve-year proportions and causes of admissions among those with neurological conditions in the US: A nationally representative study.

Objectives: Understanding admission trends and causes is essential for optimal healthcare allocation and targeted interventions to prevent hospitalizations. This study investigates hospital admissions proportions and primary causes among patients with the following neurological conditions: Brain tumors (BT), motor neuron disease (MND), multiple sclerosis (MS), Parkinson's disease (PD), spinal cord injury (SCI), traumatic brain injury (TBI), stroke, cerebral palsy (CP).

Methods: We conducted a retrospective analysis using the National Inpatient Sample (2003-2014), identifying patients of all ages with validated ICD-9-CM codes for these neurological conditions in any diagnostic position.

Fluorescence-Guided Surgery for Gliomas: Past, Present, and Future.

: Glioblastoma (GBM) is the most common primary malignant central nervous system tumor, accounting for 50.9% of malignant CNS diagnoses and carrying a median survival of 15 months despite maximal standard therapy. High recurrence rates are driven by residual infiltrative tumor cells at the resection margin.

Radiofrequency Enhancer to Recover Signal Dropouts in 7 Tesla Diffusion MRI.

Diffusion magnetic resonance imaging (dMRI) allows for a non-invasive visualization and quantitative assessment of white matter architecture in the brain by characterizing restrictions on the random motion of water molecules. Ultra-high field MRI scanners, such as those operating at 7 Tesla (7T) or higher, can boost the signal-to-noise ratio (SNR) to improve dMRI compared with what is attainable at conventional field strengths such as 3T or 1.5T.

Single-cell transcriptomic analysis of corneal organoids during development.

Corneal organoids are useful tools for disease modeling and tissue transplantation; however, they have not yet been well studied during maturation. We characterized human iPSC-derived corneal organoids at 1, 2, 3, and 4 months of development using single-cell RNA sequencing to determine the cellular heterogeneity at each stage. We found pluripotent cell clusters committed to epithelial cell lineage at 1 month; early corneal epithelial, endothelial, and stromal cell markers at 2 months; keratocytes as the largest cell population at 3 months; and a large epithelial cell population at 4 months.

Comparing vagus nerve stimulation and resective surgery outcomes in patients with co-occurring autism and epilepsy to patients with epilepsy alone: A population-based study.

Autism and epilepsy commonly co-occur. Understanding trends in healthcare utilization and in-hospital outcomes amongst patients with autism and epilepsy can help optimize care and reduce costs. We compared hospital outcomes amongst patients with autism and epilepsy to those with epilepsy alone undergoing vagus nerve stimulation (VNS) and resective/disconnective surgery.

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.

Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression.

PNP Hydrogel Prevents Formation of Symblephara in Mice After Ocular Alkali Injury.

Purpose: To create an alkali injury symblephara mouse model to study conjunctival fibrosis pathophysiology and test polymer nanoparticle (PNP) hydrogel as a preventative therapeutic.

Methods: Mice were injured using NaOH-soaked filter paper to determine the optimal NaOH concentration to induce the formation of symblephara. Injured mice were observed for 7 days to detect the formation of symblephara.

Breast Arterial Calcification in the Mammogram Report: The Patient Perspective.

Objective: The purpose of this study was to determine patient attitudes about mammographic reporting of breast arterial calcification (BAC), result communication, and action.

Subjects And Methods: A self-administered survey was created for this project and was offered to mammography patients presenting for screening or diagnostic mammography over a 1-month period.

Results: Among those who accepted questionnaires, 61.