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Article Abstract
Background: Dystonia affects an estimated 30% of patients with Parkinson's Disease (PD). While pallidal theta-alpha oscillations (4-10 Hz) have been found to characterize primary dystonia compared to beta oscillations (12-30 Hz) in PD, the electrophysiology underlying dystonia in PD remains unexplored.
Objectives: Explore the electrophysiology underlying dystonia in PD.
Methods: Subthalamic nucleus (STN) local field potentials (LFPs) in PD patients with and without dystonia were compared using a bidirectional deep brain stimulation (DBS) device.
Results: Fourteen PD patients with bilateral STN-DBS were included, four (28.6%) with lower extremity dystonia. In 3/7 hemispheres affected by dystonia (42.9%), maximum amplitude LFP activity occurred in the theta-alpha band (4-10 Hz). Conversely, all 21 hemispheres not associated with dystonia had maximum STN activity around the beta-band (11.5-35 Hz, P = 0.011).
Conclusions: STN theta-alpha activity in patients with PD may be associated with dystonic symptoms. Although other motor and non-motor features may correlate with STN theta-alpha, this biomarker warrants further investigation in closed-loop DBS.
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| http://dx.doi.org/10.1002/mdc3.70284 | DOI Listing |
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